abstract：INTRODUCTION:The treatment of hard tissue defects, especially those of bone and cartilage, induced by infections or tumors remains challenging. Traditional methods, including debridement with systematic chemotherapy, have shortcomings owing to their inability to eliminate infections and high systematic toxicity. AREA ...

journal_title：Expert opinion on drug delivery

authors： Hua L,Lei T,Qian H,Zhang Y,Hu Y,Lei P

更新日期：2021-01-19 00:00:00

abstract：:Introduction: Making selective inhibitors of novel Gram-negative targets is not a substantial challenge - getting them into Gram-negative bacteria to reach their lethal target is the bottleneck. Poor permeability of the antibiotic requires high concentration causing off target activity. The lack of simple experimental...

journal_title：Expert opinion on drug delivery

authors： Winterhalter M

更新日期：2020-11-13 00:00:00

abstract：INTRODUCTION:Nanocarrier-based delivery systems offer multiple benefits to overcome limitations of the traditional drug dosage forms, such as protection of the drug, enhanced bioavailability, targeted delivery to disease site, etc. Nanocarriers have exhibited tremendous successes in targeted delivery of therapeutics to...

journal_title：Expert opinion on drug delivery

authors： Majumder J,Minko T

更新日期：2020-10-08 00:00:00

abstract：INTRODUCTION:Macrophages are involved in the normal defense of the body; however, the varying phenotypes of macrophages and imbalance in their ratio lead to the impairment of immune response initiating the production of inflammation. As the role of macrophages in immunological disorders and their surface receptors modu...

journal_title：Expert opinion on drug delivery

authors： Mukhtar M,Ali H,Ahmed N,Munir R,Talib S,Khan AS,Ambrus R

更新日期：2020-09-01 00:00:00

abstract：INTRODUCTION:Management of Osteoarthritis (OA) still is a challenge for clinicians. Taking into account a multidisciplinary approach including pharmacological and non-pharmacological treatments, intra-articular (IA) injection could be considered as an effective local therapy. Areas covered This review provides a new pe...

journal_title：Expert opinion on drug delivery

authors： Migliore A,Paoletta M,Moretti A,Liguori S,Iolascon G

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Pressurized metered-dose inhalers (pMDIs) include hydrofluoroalkane (HFA) propellant to generate a drug aerosol upon actuation and drugs can be formulated as solution or suspension. Suspended particles can cream or sediment depending on density differences between drug and propellant and shaking the pMDI is ...

journal_title：Expert opinion on drug delivery

authors： Chierici V,Cavalieri L,Piraino A,Paleari D,Quarta E,Sonvico F,Melani AS,Buttini F

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:We hypothesized if phagocytosis of liposomes by macrophages could be mitigated through incorporation of a CD47 mimicry peptide (Self peptide: SP) on the surface of liposomes. METHODS:Thin film hydration method followed by extrusion was used to prepare nanoliposomes, and Dox encapsulation in liposomes was do...

journal_title：Expert opinion on drug delivery

authors： Gheibi Hayat SM,Jaafari MR,Hatamipour M,Jamialahmadi T,Sahebkar A

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:The Aluetta™ reusable pen device and instructions for use (IFU) for growth hormone (r-hGH; Saizen®, Merck KGaA, Darmstadt, Germany) administration were tested for Human-Factors Usability, to ensure it could be used safely and effectively by the intended users in the intended use environment. RESEARCH DESIGN ...

journal_title：Expert opinion on drug delivery

authors： Cachemaille A,Warren SE,Moss S

更新日期：2020-07-01 00:00:00

abstract：INTRODUCTION:Since decades, cancer is a major public health problem worldwide. The increasing knowledge of molecular and tumor biology has significantly changed the cancer treatment paradigms during the past few years. AREA COVERED:Conventionally, the first-line treatment of solid tumors is their surgical removal foll...

journal_title：Expert opinion on drug delivery

authors： Rahman M,Alharbi KS,Alruwaili NK,Anfinan N,Almalki WH,Padhy I,Sambamoorthy U,Swain S,Beg S

更新日期：2020-06-01 00:00:00

abstract：:Background: Anti-tumor necrosis factor (anti-TNF) adherence is suboptimal. ava®, a reusable electromechanical self-injection device (e-Device) developed for certolizumab pegol (CZP) administration, aims to overcome some barriers to increase adherence. This study evaluates patient experience of the e-Device and its tra...

journal_title：Expert opinion on drug delivery

authors： Pouls BPH,Kristensen LE,Petersson M,van den Bemt BJF,Ballerini L,Bruggraber R,Karlen H,Mountian I,van Bracht E,Wiegratz S,Jørgensen TS

更新日期：2020-05-01 00:00:00

abstract：:Introduction: Thymoquinone (TQ), 2-isopropyl-5-methylbenzo-1, 4-quinone, the main active constituent of Nigella sativa (NS) plant, has been proven to be of great therapeutic aid in various in vitro and in vivo conditions. Despite the promising therapeutic activities of TQ, this molecule is not yet in the clinical tria...

journal_title：Expert opinion on drug delivery

authors： Rathore C,Rathbone MJ,Chellappan DK,Tambuwala MM,Pinto TJA,Dureja H,Hemrajani C,Gupta G,Dua K,Negi P

更新日期：2020-04-01 00:00:00

abstract：:Introduction: Cisplatin has been indicated for several malignancies all over the world for many years. Increasing patient tolerance for high dose of chemotherapeutics and reducing side effects has been granted by drug encapsulated liposomal systems. There have been much efforts for improving cisplatin delivery to the ...

journal_title：Expert opinion on drug delivery

authors： Zahednezhad F,Zakeri-Milani P,Shahbazi Mojarrad J,Valizadeh H

更新日期：2020-04-01 00:00:00

abstract：:Introduction: Pulmonary drug delivery is a complex field of research combining physics which drive aerosol transport and deposition and biology which underpins efficacy and toxicity of inhaled drugs. A myriad of preclinical methods, ranging from in-silico to in-vitro, ex-vivo and in-vivo, can be implemented.Areas cove...

journal_title：Expert opinion on drug delivery

authors： Ehrmann S,Schmid O,Darquenne C,Rothen-Rutishauser B,Sznitman J,Yang L,Barosova H,Vecellio L,Mitchell J,Heuze-Vourc'h N

更新日期：2020-04-01 00:00:00

abstract：:Introduction: Poloxamer based in situ gelling systems offer numerous advantages in drug delivery; however, their application as prolonged-release delivery platforms is limited mainly due to their weak mechanical properties and the interconnected aqueous network causing fast gel erosion and drug diffusion.Area covered:...

journal_title：Expert opinion on drug delivery

authors： Abdeltawab H,Svirskis D,Sharma M

更新日期：2020-04-01 00:00:00

abstract：:Background: Atopic dermatitis is a chronic inflammatory skin disease that remarkably affects the quality-of-life of patients. Chamomile oil is used to treat skin inflammations. We evaluated the efficacy of chamomile oil and nanoemulgel formulations as a natural alternative therapeutic option for atopic dermatitis.Rese...

journal_title：Expert opinion on drug delivery

authors： El-Salamouni NS,Ali MM,Abdelhady SA,Kandil LS,Elbatouti GA,Farid RM

更新日期：2020-01-01 00:00:00

abstract：:Introduction: Current therapies of neurodegenerative or neurometabolic diseases are, to a large extent, hampered by the inability of drugs to cross the blood-brain barrier (BBB). This very tight barrier severely restricts the entrance of molecules from the blood into the brain, especially macromolecular substances (i....

journal_title：Expert opinion on drug delivery

authors： Tosi G,Duskey JT,Kreuter J

更新日期：2020-01-01 00:00:00

abstract：:Introduction: Peritoneal metastases of cancer remain a major cause of an adverse outcome and death following surgical treatment of malignancies that occur within the abdomen and pelvis. The administration of a chemotherapy solution directly into the peritoneal space has been used to improve the survival in this group ...

journal_title：Expert opinion on drug delivery

authors： Sugarbaker PH

更新日期：2019-12-01 00:00:00

abstract：:Introduction: Incorrect inhaler technique is one reason why the efficacies of inhaled asthma treatments in clinical trials and effectiveness in the real world differ. Inhaler technique is critical for drug delivery to the lungs; incorrect technique negatively impacts asthma control and long-term outcomes. Breath-trigg...

journal_title：Expert opinion on drug delivery

authors： Usmani O,Roche N,Marshall J,Danagher H,Price D

更新日期：2019-12-01 00:00:00

abstract：:Background: To overcome the rigorous aseptic process widely adopted by commercial long-acting injections, this work aimed to prepare a sterile MPA injection by manipulating the crystal habit through a bottom-up method. Methods: The habit of the precipitated crystals was modified by changing the process conditions. Whe...

journal_title：Expert opinion on drug delivery

authors： Sun R,Guo Y,Yin N,Yin J,Yin T,He H,Gou J,Zhang Y,Tang X

更新日期：2019-10-01 00:00:00

abstract：:Introduction: Systemically administered non-viral gene delivery systems face multiple biological barriers that decrease their efficiency. These systems are rapidly cleared from the circulation and sufficient concentrations do not accumulate in diseased tissues. A number of targeting strategies can be used to provide f...

journal_title：Expert opinion on drug delivery

authors： Khalil IA,Sato Y,Harashima H

更新日期：2019-10-01 00:00:00

abstract：:Introduction: Sativex® spray is clinically utilized to deliver delta9-tetrahydrocannabinol and cannabidiol to oral mucosa for systemic absorption. We challenge the consensus that the mechanism of absorption following the oro-mucosal application occurs via the buccal tissue. Areas covered: Correctness of the consensus ...

journal_title：Expert opinion on drug delivery

authors： Itin C,Domb AJ,Hoffman A

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:Transportation of the nutrients and other substances from the blood to the brain is selectively controlled by the brain capillary endothelial cells that form a restrictive barrier, so-called blood-brain barrier (BBB). Currently, there is no unimpeachable approach to overcome the BBB obstructiveness because...

journal_title：Expert opinion on drug delivery

authors： Jafari B,Pourseif MM,Barar J,Rafi MA,Omidi Y

更新日期：2019-06-01 00:00:00

abstract：:Objective: Conventional chloramphenicol (CHL) eye drops are widely used anti-infection formulations for acute bacterial conjunctivitis. However, the therapeutic effects are limited by insufficient concentration in the conjunctival sac. Hence, the objective of this study is to formulate and develop novel CHL eye drops ...

journal_title：Expert opinion on drug delivery

authors： Xu Y,Zhang C,Zhu X,Wang X,Wang H,Hu G,Fu Q,He Z

更新日期：2019-06-01 00:00:00

abstract：INTRODUCTION:The emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) is a major health issue and continues to be a global health concern. Despite significant advancements in treatment modalities, ~1.6 million deaths worldwide occur due to TB infection. This is bec...

journal_title：Expert opinion on drug delivery

authors： Sankhe K,Khan T,Bhavsar C,Momin M,Omri A

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:Currently, hot melt extrusion (HME) is a promising technology in the pharmaceutical industry, as evidenced by its application to manufacture various FDA-approved commercial products in the market. HME is extensively researched for enhancing the solubility and bioavailability of poor water-soluble drugs, ta...

journal_title：Expert opinion on drug delivery

authors： Kallakunta VR,Sarabu S,Bandari S,Tiwari R,Patil H,Repka MA

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Increasing interest in digitally enhanced drug delivery tools urges both industry and academia to rethink current approaches to product usability testing. This article introduces mobile eye-tracking, generating detailed contextual data about user engagement with connected self-injection systems as a new meth...

journal_title：Expert opinion on drug delivery

authors： Lohmeyer Q,Schneider A,Jordi C,Lange J,Meboldt M

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:The advent of therapeutic proteins highlights the need for delivery systems that protect and extend the duration of its action. Ranibizumab-VEGF is one such drug used for treating wet AMD. This paper describes a facile method to sustain bioactive ranibizumab release from PLGA-based particles. METHODS:Two em...

journal_title：Expert opinion on drug delivery

authors： Chua HY,Lui YS,Bhuthalingam R,Agrawal R,Wong T,Preiser PR,Venkatraman S

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:The distribution and metabolism of a drug in the organism are dependent on the administration route as well as on the drug formulation. It is important to be able to assess which impact the administration route or formulation of a drug has for its distribution and metabolism. METHODS:The antidepressant drug...

journal_title：Expert opinion on drug delivery

authors： Morineau L,Jacobsen SC,Kleberg K,Hansen HS,Janfelt C

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVES:Clinical translation of siRNA therapeutics has been severely limited due to the lack of stable and sustained siRNA delivery systems. Furthermore, when nanocarrier systems with siRNA are administered systemically to treat diseases, insufficient doses reach the target tissue. Here we report the successful deve...

journal_title：Expert opinion on drug delivery

authors： Tan YF,Lee YS,Seet LF,Ng KW,Wong TT,Venkatraman S

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:The present work aims to formulate nanostructured lipid carriers (NLCs) exhibiting high skin deposition and high inherent antioxidant potential to repurpose the use of melatonin hormone and some antioxidant oils in the treatment of androgenic alopecia (AGA). RESEARCH DESIGN AND METHODS:NLCs were characteriz...

journal_title：Expert opinion on drug delivery

authors： Hatem S,Nasr M,Moftah NH,Ragai MH,Geneidi AS,Elkheshen SA

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:Interest in mesoporous silica nanoparticles for drug delivery has resulted in a good understanding of the impact of size and surface chemistry of these nanoparticles on their performance as drug carriers. Shape has emerged as an additional factor that can have a significant effect on delivery efficacy. Rod...

journal_title：Expert opinion on drug delivery

authors： Cong VT,Gaus K,Tilley RD,Gooding JJ

更新日期：2018-09-01 00:00:00

abstract：INTRODUCTION:Research into oral delivery of biologics has a long and rich history but has not produced technologies used in the clinic. The area has evolved in terms of strategies to promote oral biologics delivery from early chemical absorption enhancers to nanomedicine to devices. Continued activity in this area is j...

journal_title：Expert opinion on drug delivery

authors： Vllasaliu D,Thanou M,Stolnik S,Fowler R

更新日期：2018-08-01 00:00:00

abstract：INTRODUCTION:Considering that the number of patients afflicted by posterior eye diseases is increasing, effective drug delivery is currently in high clinical demand. Topical administration has been identified as the preferred option, while sufferingfrom multiple barriers. The development of nanoparticle-based drug deli...

journal_title：Expert opinion on drug delivery

authors： Wang Y,Xu X,Gu Y,Cheng Y,Cao F

更新日期：2018-07-01 00:00:00

abstract：INTRODUCTION:Nanoparticles are anticipated to overcome persistent challenges in efficient drug delivery, but the limitations associated with conventional methods of preparation are resulting in slow translation from research to clinical applications. Due to their enormous potential, microfluidic technologies have emerg...

journal_title：Expert opinion on drug delivery

authors： Martins JP,Torrieri G,Santos HA

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION:Lymphatic vessels are the preferential route of most solid tumors to spread their metastases in the body. The onset of metastatic nests in draining lymph nodes (LNs) are a significant indicator of cancer progression and a dismaying sign of worsen staging. Therefore, the individuation and elimination of can...

journal_title：Expert opinion on drug delivery

authors： Obinu A,Gavini E,Rassu G,Maestri M,Bonferoni MC,Giunchedi P

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION:The development of therapeutics for central nervous system (CNS) disorders is still considered a challenging area in drug development due to insufficient translocation through the blood-brain barrier (BBB). Under normal conditions, BBB restrict the penetration of more than 98% of blood-borne molecules incl...

journal_title：Expert opinion on drug delivery

authors： Al-Ahmady ZS

更新日期：2018-04-01 00:00:00

abstract：INTRODUCTION:Radioimmunotherapy (RIT) with monoclonal antibodies and their fragments labelled with radionuclides emitting α -particles, β-particles or Auger electrons have been used for many years in the development of anticancer strategies. While RIT has resulted in approved radiopharmaceuticals for the treatment of h...

journal_title：Expert opinion on drug delivery

authors： Martins CD,Kramer-Marek G,Oyen WJG

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:Sixty years since its introduction, 5-FU still forms the core of chemotherapy regimens for many types of malignancies. 5-FU is a time-dependent drug but is rapidly degraded in plasma by dihydropyrimidine dehydrogenase (DPD). Although originally developed in an intravenous form, 5-FU oral prodrugs were deve...

journal_title：Expert opinion on drug delivery

authors： Miura K,Shima H,Takebe N,Rhie J,Satoh K,Kakugawa Y,Satoh M,Kinouchi M,Yamamoto K,Hasegawa Y,Kawai M,Kanazawa K,Fujiya T,Unno M,Katakura R

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:The utility of controlled and sustained release of drugs from polymeric systems, both bulk (hydrogels) and colloids (nanoparticles), is a key point that should be addressed. Unfortunately, classic delivery systems are essentially driven by diffusion, which is very quick due to the high concentration gradie...

journal_title：Expert opinion on drug delivery

authors： Mauri E,Papa S,Masi M,Veglianese P,Rossi F

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:Recent developments in ultrasound imaging and ultrasound contrast agents (UCAs) improved diagnostic confidence in echography and set into motion their combined use as a tool for drug delivery and therapeutic monitoring. Non-invasive, precise and targeted delivery of drug molecules to pathological tissues b...

journal_title：Expert opinion on drug delivery

authors： Sennoga CA,Kanbar E,Auboire L,Dujardin PA,Fouan D,Escoffre JM,Bouakaz A

更新日期：2017-09-01 00:00:00