Drug, delivery and devices for diabetic retinopathy (3Ds in DR).

abstract：INTRODUCTION:In situ gel systems refer to a class of novel delivery vehicles, composed of natural, semisynthetic or synthetic polymers, which present the unique property of sol-gel conversion on receipt of biological stimulus. AREAS COVERED:The present review summarizes the latest developments in in situ gel technolog...

journal_title：Expert opinion on drug delivery

authors： Agrawal AK,Das M,Jain S

更新日期：2012-04-01 00:00:00

abstract：INTRODUCTION:Polymers can be designed to modify their features as a function of the level and nature of the surrounding microorganisms. Such responsive polymers can endow drug delivery systems and drug-medical device combination products with improved performance against intracellular infections and biofilms. AREAS CO...

journal_title：Expert opinion on drug delivery

authors： Alvarez-Lorenzo C,Garcia-Gonzalez CA,Bucio E,Concheiro A

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVES:To develop orodispersible films (ODF) based on hydrophobic polymers with higher stability to ordinary environmental humidity conditions without compromising their fast disintegration time. METHODS:A quality by design approach was applied to screen three different formulations each one based on a different h...

journal_title：Expert opinion on drug delivery

authors： Borges AF,Silva BM,Silva C,Coelho JF,Simões S

更新日期：2016-10-01 00:00:00

abstract：:Introduction: Thymoquinone (TQ), 2-isopropyl-5-methylbenzo-1, 4-quinone, the main active constituent of Nigella sativa (NS) plant, has been proven to be of great therapeutic aid in various in vitro and in vivo conditions. Despite the promising therapeutic activities of TQ, this molecule is not yet in the clinical tria...

journal_title：Expert opinion on drug delivery

authors： Rathore C,Rathbone MJ,Chellappan DK,Tambuwala MM,Pinto TJA,Dureja H,Hemrajani C,Gupta G,Dua K,Negi P

更新日期：2020-04-01 00:00:00

abstract：INTRODUCTION:Nanoparticles are anticipated to overcome persistent challenges in efficient drug delivery, but the limitations associated with conventional methods of preparation are resulting in slow translation from research to clinical applications. Due to their enormous potential, microfluidic technologies have emerg...

journal_title：Expert opinion on drug delivery

authors： Martins JP,Torrieri G,Santos HA

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION:Delivery of macromolecular drugs is an important field in medical research. However, macromolecules are usually unable to cross the cell membrane without the assistance of a delivery system. Cell penetrating peptides (CPPs) are unique tools to gain access to the cell interior and deliver a bioactive cargo ...

journal_title：Expert opinion on drug delivery

authors： Kurrikoff K,Gestin M,Langel Ü

更新日期：2016-01-01 00:00:00

abstract：:Nitric oxide (NO), the 1992 'Molecule of the Year', is the focus of immense medical and scientific exploration. Interest in NO has grown exponentially since the initial and relatively recent discovery that NO is the long sought after endothelial relaxing factor. There is intense research that is continuing to expose t...

journal_title：Expert opinion on drug delivery

authors： Friedman A,Friedman J

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:The lung comprises an interesting route of administration not only for topical drugs but also for systemically acting drugs. Over the last years, several models have been developed in order to study the efficacy and safety of pulmonary drug delivery. OBJECTIVE:This review describes relevant drug delivery mo...

journal_title：Expert opinion on drug delivery

authors： Fernandes CA,Vanbever R

更新日期：2009-11-01 00:00:00

abstract：INTRODUCTION:Bisphosphonates (BPs) were introduced 45 years ago as anti-osteoporotic drugs and during the last decade have been utilized as bone-targeting groups in systemic treatment of bone diseases. Very recently, strategies of chemical immobilization of BPs in hydrogels and nanocomposites for bone tissue engineerin...

journal_title：Expert opinion on drug delivery

authors： Ossipov DA

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:A major problem with conventional antitumor therapeutics is nonselective delivery of cytotoxic drugs to normal vital organs and tissues but little delivery to tumor tissues. AREAS COVERED:Here, the authors describe the tumor selective delivery of antitumor drugs by taking advantage of nano-sized drugs and...

journal_title：Expert opinion on drug delivery

authors： Nakamura H,Fang J,Maeda H

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Harnessing RNA interference as a therapeutic approach has the potential to significantly expand the druggable target space, offering new hope for treatment of diseases that cannot be addressed with existing classes of drugs. A number of siRNA therapeutics have already progressed into preclinical and clinic...

journal_title：Expert opinion on drug delivery

authors： Gindy ME,Leone AM,Cunningham JJ

更新日期：2012-02-01 00:00:00

abstract：INTRODUCTION:Nanocarrier-based delivery systems offer multiple benefits to overcome limitations of the traditional drug dosage forms, such as protection of the drug, enhanced bioavailability, targeted delivery to disease site, etc. Nanocarriers have exhibited tremendous successes in targeted delivery of therapeutics to...

journal_title：Expert opinion on drug delivery

authors： Majumder J,Minko T

更新日期：2020-10-08 00:00:00

abstract：IMPORTANCE OF THE FIELD:Active targeting of bioactive molecules by physicochemical association with hyaluronic acid (HA) is an attractive approach in current nanomedicine because HA is biocompatible, non-toxic and non-inflammatory. AREAS COVERED IN THIS REVIEW:This review focuses on synthesis, physicochemical characte...

journal_title：Expert opinion on drug delivery

authors： Ossipov DA

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:The present work aims to formulate nanostructured lipid carriers (NLCs) exhibiting high skin deposition and high inherent antioxidant potential to repurpose the use of melatonin hormone and some antioxidant oils in the treatment of androgenic alopecia (AGA). RESEARCH DESIGN AND METHODS:NLCs were characteriz...

journal_title：Expert opinion on drug delivery

authors： Hatem S,Nasr M,Moftah NH,Ragai MH,Geneidi AS,Elkheshen SA

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:Carbohydrates are key participants in many biological processes including reproduction, inflammation, signal transmission and infection. Their biocompatibility and ability to be recognized by cell-surface receptors illustrate their potential therapeutic applications. αYet, they are not ideal candidates bec...

journal_title：Expert opinion on drug delivery

authors： Sunasee R,Adokoh CK,Darkwa J,Narain R

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVES:Methotrexate (MTX) is a chemotherapeutic and anti-inflammatory drug that may cause systemic adverse effects. This study investigated kinetics and biodistribution of MTX delivered topically by ablative fractional laser (AFXL). METHODS:In vitro passive diffusion of 10 mg/ml MTX (1 w/v%) was measured from 0.25...

journal_title：Expert opinion on drug delivery

authors： Taudorf EH,Lerche CM,Vissing AC,Philipsen PA,Hannibal J,D'Alvise J,Hansen SH,Janfelt C,Paasch U,Anderson RR,Haedersdal M

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Augmentation of simvastatin (SMV) cytotoxicity in breast carcinoma cell lines MCF-7, by: improvement of cellular uptake and loading on alpha lipoic acid (ALA). METHODS:In this study, SMV was loaded on ALA nanoparticles and characterized for surface morphology, SMV entrapment efficiency percent (%EE), zeta p...

journal_title：Expert opinion on drug delivery

authors： Fahmy UA,Aljaeid BM

更新日期：2016-12-01 00:00:00

abstract：:Oral colon-targeted drug delivery systems have gained enormous attention among researchers in the last two decades. The significance of this site-specific drug delivery system can be measured by its usefulness for delivering a variety of therapeutic agents, both for the treatment of local diseases or for systemic ther...

journal_title：Expert opinion on drug delivery

authors： Patel MM

更新日期：2011-10-01 00:00:00

abstract：:Skin diseases are prevalent and can significantly affect quality of life. Empirical mathematical models retrospectively analyse data to predict skin permeation from the physico-chemical properties of drugs. Quantitative structure permeability relationships are discussed, along with alternatives to linear modelling. Me...

journal_title：Expert opinion on drug delivery

authors： Russell LM,Guy RH

更新日期：2009-04-01 00:00:00

abstract：INTRODUCTION:Overactive bladder affects a significant portion of the population and results in prescribing of numerous medications for its treatment. Traditional drug delivery systems used in therapy are associated with multiple commonly reported side effects. Adherence rates with use of these medications are low. It i...

journal_title：Expert opinion on drug delivery

authors： Scott K,Dmochowski RR,Padmanabhan P

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:Clinical translation of siRNA therapeutics has been severely limited due to the lack of stable and sustained siRNA delivery systems. Furthermore, when nanocarrier systems with siRNA are administered systemically to treat diseases, insufficient doses reach the target tissue. Here we report the successful deve...

journal_title：Expert opinion on drug delivery

authors： Tan YF,Lee YS,Seet LF,Ng KW,Wong TT,Venkatraman S

更新日期：2018-10-01 00:00:00

abstract：:The CYPHER (Cordis, Johnson & Johnson) sirolimus-eluting stent and the TAXU (Boston Scientific) paclitaxel-eluting stent have been extensively evaluated and have been proven to be significant novel tools for the treatment of coronary artery disease. Several sirolimus derivatives have already emerged, receiving CE Mark...

journal_title：Expert opinion on drug delivery

authors： Vaina S,Serruys PW

更新日期：2006-11-01 00:00:00

abstract：:Liver fibrosis and its end stage disease cirrhosis are a major cause of mortality and morbidity around the world. There is no effective pharmaceutical intervention for liver fibrosis at present. Many drugs that show potent antifibrotic activities in vitro often show only minor effects in vivo because of insufficient c...

journal_title：Expert opinion on drug delivery

authors： Li F,Wang JY

更新日期：2009-05-01 00:00:00

abstract：INTRODUCTION:Even though pulmonary diseases are among the leading causes of morbidity and mortality in the world, exceedingly few life-prolonging therapies have been developed for these maladies. Relief may finally come from nanomedicine and targeted drug delivery. AREAS COVERED:Here, we focus on four conditions for w...

journal_title：Expert opinion on drug delivery

authors： Brenner JS,Greineder C,Shuvaev V,Muzykantov V

更新日期：2015-02-01 00:00:00

abstract：INTRODUCTION:Development of efficient in vivo delivery systems remains a major challenge en route to clinical application of antisense technology, including RNA-cleaving molecules such as deoxyribozymes (DNAzymes). The mechanisms of oligonucleotide uptake and trafficking are clearly dependent on cell type and the type ...

journal_title：Expert opinion on drug delivery

authors： Fokina AA,Chelobanov BP,Fujii M,Stetsenko DA

更新日期：2017-09-01 00:00:00

abstract：INTRODUCTION:Long circulating liposomal drug carriers are widely used in experimental cancer therapy because they avoid excretion and benefit from the enhanced permeability and retention-effect to accumulate at the tumor site while simultaneously limiting systemic exposure to the cytotoxic drug due to their high stabil...

journal_title：Expert opinion on drug delivery

authors： Oude Blenke E,Mastrobattista E,Schiffelers RM

更新日期：2013-10-01 00:00:00

abstract：INTRODUCTION:Peptide and protein microarray and microneedle array technology provides direct information on protein function and potential drug targets in drug discovery and delivery. Because of this unique ability, these arrays are well suited for protein profiling, drug target identification/validation and studies of...

journal_title：Expert opinion on drug delivery

authors： Chandrasekhar S,Iyer LK,Panchal JP,Topp EM,Cannon JB,Ranade VV

更新日期：2013-08-01 00:00:00

abstract：:Background: Anti-tumor necrosis factor (anti-TNF) adherence is suboptimal. ava®, a reusable electromechanical self-injection device (e-Device) developed for certolizumab pegol (CZP) administration, aims to overcome some barriers to increase adherence. This study evaluates patient experience of the e-Device and its tra...

journal_title：Expert opinion on drug delivery

authors： Pouls BPH,Kristensen LE,Petersson M,van den Bemt BJF,Ballerini L,Bruggraber R,Karlen H,Mountian I,van Bracht E,Wiegratz S,Jørgensen TS

更新日期：2020-05-01 00:00:00

abstract：INTRODUCTION:Current treatment of malignant tumors relies predominantly on chemotherapy delivering a single antineoplastic drug or a combination of two or more drugs intravenously. Problems with such treatments can include the killing of healthy cells, adverse side effects and chemoresistance. As cancer basically resul...

journal_title：Expert opinion on drug delivery

authors： Chowdhury EH

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:Test the hypothesis that pegylated meglumine antimoniate-containing liposomes (LMA) and their mixture with non-pegylated (conventional) LMA may be more effective than conventional LMA against visceral leishmaniasis (VL), because of wider drug distribution among different mononuclear phagocyte system (MPS) tis...

journal_title：Expert opinion on drug delivery

authors： Azevedo EG,Ribeiro RR,da Silva SM,Ferreira CS,de Souza LE,Ferreira AA,de Oliveira E Castro RA,Demicheli C,Rezende SA,Frézard F

更新日期：2014-10-01 00:00:00