'Smart' nanoparticles as drug delivery systems for applications in tumor therapy.

abstract：:Directly delivering liquid using direct current power was a dream for 40 years. Now, the electrokinetic pump can accomplish it. This review reports recent developments in microfabricated electrokinetic pump technologies and their applications, and also discusses the electrophoresis pump and elctroosmotic pump, as well...

journal_title：Expert opinion on drug delivery

authors： Chen L,Choo J,Yan B

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Liposomes, phospholipids, nanosized bubbles with a bilayered membrane structure, have drawn a lot of interest as pharmaceutical carriers for drugs and genes. In particular, liposomes are widely used for drug delivery into tumors. OBJECTIVE:In many cases, to enhance the efficacy of the liposomal drugs, drug-...

journal_title：Expert opinion on drug delivery

authors： Torchilin V

更新日期：2008-09-01 00:00:00

abstract：INTRODUCTION:The use of hydrophilic polymers as a substitute for the Fc-domain in immuno- or non-immuno-based binding proteins is accelerating. Chemical PEGylation has led the way and is still the most advanced and clinically-approved approach. Hydrophilic polymers act by maintaining a flexible conformation and hydroge...

journal_title：Expert opinion on drug delivery

authors： Chen C,Constantinou A,Deonarain M

更新日期：2011-09-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Drug combinations have been the standard of care in the treatment of cancer for > 50 years. Typically, combination chemotherapy uses agents with non-overlapping toxicities which are escalated to their maximum tolerated dose. However, emerging evidence indicates that this approach may not be prov...

journal_title：Expert opinion on drug delivery

authors： Dicko A,Mayer LD,Tardi PG

更新日期：2010-12-01 00:00:00

abstract：:Skin diseases are prevalent and can significantly affect quality of life. Empirical mathematical models retrospectively analyse data to predict skin permeation from the physico-chemical properties of drugs. Quantitative structure permeability relationships are discussed, along with alternatives to linear modelling. Me...

journal_title：Expert opinion on drug delivery

authors： Russell LM,Guy RH

更新日期：2009-04-01 00:00:00

abstract：:The treatment of genetic diseases using therapeutic gene transfer is considered to be a significant development. This development has brought with it certain limitations, and the process of overcoming these barriers has seen a drastic change in gene delivery. Many metal ions such as Mg2+, Mn2+, Ba2+ and, most importan...

journal_title：Expert opinion on drug delivery

authors： Kulkarni VI,Shenoy VS,Dodiya SS,Rajyaguru TH,Murthy RR

更新日期：2006-03-01 00:00:00

abstract：INTRODUCTION:A nanosuspension or nanocrystal suspension is a versatile formulation combining conventional and innovative features. It comprises 100% pure drug nanoparticles with sizes in the nano-scale range, generally stabilized by surfactants or polymers. Nanosuspensions are usually obtained in liquid media with bott...

journal_title：Expert opinion on drug delivery

authors： Leone F,Cavalli R

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Lymphatic vessels are the preferential route of most solid tumors to spread their metastases in the body. The onset of metastatic nests in draining lymph nodes (LNs) are a significant indicator of cancer progression and a dismaying sign of worsen staging. Therefore, the individuation and elimination of can...

journal_title：Expert opinion on drug delivery

authors： Obinu A,Gavini E,Rassu G,Maestri M,Bonferoni MC,Giunchedi P

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION:In situ gel systems refer to a class of novel delivery vehicles, composed of natural, semisynthetic or synthetic polymers, which present the unique property of sol-gel conversion on receipt of biological stimulus. AREAS COVERED:The present review summarizes the latest developments in in situ gel technolog...

journal_title：Expert opinion on drug delivery

authors： Agrawal AK,Das M,Jain S

更新日期：2012-04-01 00:00:00

abstract：INTRODUCTION:Diabetic Retinopathy (DR) is one of the most common causes of blindness among the working population worldwide. Clearly, there is an unmet clinical need to find better treatment options for DR. Areas covered: The literature search was conducted on PubMed with no limitation on language or year of publicatio...

journal_title：Expert opinion on drug delivery

authors： Nirmal J,Radhakrishnan K,Moreno M,Natarajan JV,Laude A,Lim TH,Venkatraman S,Agrawal R

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:The aim of the present study is to evaluate the influence of factors such as biopharmaceutical properties and study protocol on the emptying of pellets from the human stomach in a fed state. METHODS:A systematic literature search for data on human gastric emptying of pellets from a fed stomach state investi...

journal_title：Expert opinion on drug delivery

authors： Bürmen B,Locatelli I,Mrhar A,Bogataj M

更新日期：2015-08-01 00:00:00

abstract：:Introduction: Sativex® spray is clinically utilized to deliver delta9-tetrahydrocannabinol and cannabidiol to oral mucosa for systemic absorption. We challenge the consensus that the mechanism of absorption following the oro-mucosal application occurs via the buccal tissue. Areas covered: Correctness of the consensus ...

journal_title：Expert opinion on drug delivery

authors： Itin C,Domb AJ,Hoffman A

更新日期：2019-10-01 00:00:00

abstract：:Introduction: Cisplatin has been indicated for several malignancies all over the world for many years. Increasing patient tolerance for high dose of chemotherapeutics and reducing side effects has been granted by drug encapsulated liposomal systems. There have been much efforts for improving cisplatin delivery to the ...

journal_title：Expert opinion on drug delivery

authors： Zahednezhad F,Zakeri-Milani P,Shahbazi Mojarrad J,Valizadeh H

更新日期：2020-04-01 00:00:00

abstract：:Various techniques have been developed to prepare nanoparticles for the delivery of drugs. The implementation of these techniques for large-scale production is still in its infancy, as it requires defined steps which include excipient compatibility, process feasibility, formulation optimization, process optimization, ...

journal_title：Expert opinion on drug delivery

authors： Saraf S

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVES:This study focuses on the development of amlodipine bilayer buccal tablets of hydroxypropyl methylcellulose (HPMC) matrix system containing polyacrylate polymer (Carbopol(®))/β-cyclodextrin as the drug layer and ethylcellulose as the non-swellable backing layer, and their biointerfacial phenomena. METHODS:T...

journal_title：Expert opinion on drug delivery

authors： Panda B,Subhadarsini R,Mallick S

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Use of pre-filled syringes as both a packaging and delivery system for pharmaceutical drug products is accelerating. Pre-filled syringes must meet the quality and suitability for use requirements for both systems, including compatibility with the drug product. Relevant incompatibilities between pre-filled ...

journal_title：Expert opinion on drug delivery

authors： Jenke DR

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:Drug release and oral absorption of drugs with pH-dependent solubility are influenced by the conditions in the gastrointestinal tract. In some cases, poor oral absorption has been observed for these drugs, causing insufficient drug efficacy. The pH-modification of a formulation could be a promising approac...

journal_title：Expert opinion on drug delivery

authors： Taniguchi C,Kawabata Y,Wada K,Yamada S,Onoue S

更新日期：2014-04-01 00:00:00

abstract：INTRODUCTION:Recent developments in ultrasound imaging and ultrasound contrast agents (UCAs) improved diagnostic confidence in echography and set into motion their combined use as a tool for drug delivery and therapeutic monitoring. Non-invasive, precise and targeted delivery of drug molecules to pathological tissues b...

journal_title：Expert opinion on drug delivery

authors： Sennoga CA,Kanbar E,Auboire L,Dujardin PA,Fouan D,Escoffre JM,Bouakaz A

更新日期：2017-09-01 00:00:00

abstract：INTRODUCTION:Recent advances in pharmacological therapies to treat ocular diseases such as glaucoma, age-related macular degeneration, diabetic macular edema and retinal vascular occlusions have greatly improved the prognosis for these diseases. Due to these advances in pharmacological therapy, there is a great deal of...

journal_title：Expert opinion on drug delivery

authors： Kang-Mieler JJ,Osswald CR,Mieler WF

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:The renaissance in drug delivery research during the past decade led to several new approaches toward vaccine development. Transdermal immunization (TI) is a promising modality with both practical and immunological merits. Compared with conventional routes of administration, this needle-free delivery appro...

journal_title：Expert opinion on drug delivery

authors： Mishra DK,Dhote V,Mishra PK

更新日期：2013-02-01 00:00:00

abstract：INTRODUCTION:Overactive bladder affects a significant portion of the population and results in prescribing of numerous medications for its treatment. Traditional drug delivery systems used in therapy are associated with multiple commonly reported side effects. Adherence rates with use of these medications are low. It i...

journal_title：Expert opinion on drug delivery

authors： Scott K,Dmochowski RR,Padmanabhan P

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:Test the hypothesis that pegylated meglumine antimoniate-containing liposomes (LMA) and their mixture with non-pegylated (conventional) LMA may be more effective than conventional LMA against visceral leishmaniasis (VL), because of wider drug distribution among different mononuclear phagocyte system (MPS) tis...

journal_title：Expert opinion on drug delivery

authors： Azevedo EG,Ribeiro RR,da Silva SM,Ferreira CS,de Souza LE,Ferreira AA,de Oliveira E Castro RA,Demicheli C,Rezende SA,Frézard F

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:Many new drug substances have low aqueous solubility which can cause poor bioavailability after oral administration. The application of solid dispersions is a useful method to increase the dissolution rate of these drugs and thereby improve their bioavailability. So far, several methods have been developed...

journal_title：Expert opinion on drug delivery

authors： Srinarong P,de Waard H,Frijlink HW,Hinrichs WL

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Efficient and minimally invasive vector systems appear to be the most appropriate for both gene therapy and drug delivery. Numerous viral and non-viral vectors have been developed. Each vector has its own advantages and limitations. OBJECTIVE:New vectors have been required for overcoming the limitations of ...

journal_title：Expert opinion on drug delivery

authors： Kaneda Y

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:The present work aims to formulate nanostructured lipid carriers (NLCs) exhibiting high skin deposition and high inherent antioxidant potential to repurpose the use of melatonin hormone and some antioxidant oils in the treatment of androgenic alopecia (AGA). RESEARCH DESIGN AND METHODS:NLCs were characteriz...

journal_title：Expert opinion on drug delivery

authors： Hatem S,Nasr M,Moftah NH,Ragai MH,Geneidi AS,Elkheshen SA

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:Reversible Addition Fragmentation Chain Transfer (RAFT) polymerisation is now an established tool for polymer chemists to create various polymer architectures with precise control over the molecular weight, and to install a variety of different moieties onto the polymer chain ends. Recently, there seems to...

journal_title：Expert opinion on drug delivery

authors： Gregory A,Stenzel MH

更新日期：2011-02-01 00:00:00

abstract：:The use of gated mesoporous silica solids as suitable systems for controlled-release protocols is reviewed. These materials are based on mesoporous silica supports that can be prepared with tailor-made pores of around 2 - 10 nm and that show a very large specific surface area (up to 1200 m(2)/g), thus having a large l...

journal_title：Expert opinion on drug delivery

authors： Aznar E,Martínez-Máñez R,Sancenón F

更新日期：2009-06-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Efficient systemic delivery of low-molecular-mass therapeutics to neuronal tissue remains a central issue not only to drug development but also to the chronic treatment of a range of neurodegenerative disorders. AREAS COVERED IN THIS REVIEW:This review discusses the potential of using RNA inter...

journal_title：Expert opinion on drug delivery

authors： Campbell M,Ozaki E,Humphries P

更新日期：2010-07-01 00:00:00

abstract：INTRODUCTION:Radioimmunotherapy (RIT) with monoclonal antibodies and their fragments labelled with radionuclides emitting α -particles, β-particles or Auger electrons have been used for many years in the development of anticancer strategies. While RIT has resulted in approved radiopharmaceuticals for the treatment of h...

journal_title：Expert opinion on drug delivery

authors： Martins CD,Kramer-Marek G,Oyen WJG

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:Harnessing RNA interference as a therapeutic approach has the potential to significantly expand the druggable target space, offering new hope for treatment of diseases that cannot be addressed with existing classes of drugs. A number of siRNA therapeutics have already progressed into preclinical and clinic...

journal_title：Expert opinion on drug delivery

authors： Gindy ME,Leone AM,Cunningham JJ

更新日期：2012-02-01 00:00:00