Abstract:
OBJECTIVES:The aim of the present study is to evaluate the influence of factors such as biopharmaceutical properties and study protocol on the emptying of pellets from the human stomach in a fed state. METHODS:A systematic literature search for data on human gastric emptying of pellets from a fed stomach state investigated by γ-scintigraphy was carried out. After selection of comparable data, a joint statistical analysis on the basis of multiple linear regression with 132 individual t50 values (time for 50% of the pellets to be emptied from the stomach) was performed. Parameters such as a second meal administration that can influence t50 values were also examined and included into the interpretation of the results. RESULTS:The results showed that an increase in the caloric value of the meal in the interval between 1200 and 3600 kJ increased the mean t50 value. Pellets with a density of 2.8 g/cm(3) remained in the stomach longer than pellets of usual density with the same caloric value of the meal. Pellets incorporated in a tablet are emptied faster from the stomach than encapsulated pellets. A 45-min delay in the application of pellets after the start of the meal significantly diminished the mean t50 value, compared with application immediately after consuming the meal. CONCLUSION:Thus, in the development of non-disintegrating pellets intended for fed-state application, all of these cited factors should be considered because of their potential influence on the gastric residence time.
journal_name
Expert Opin Drug Delivjournal_title
Expert opinion on drug deliveryauthors
Bürmen B,Locatelli I,Mrhar A,Bogataj Mdoi
10.1517/17425247.2015.1035707subject
Has Abstractpub_date
2015-08-01 00:00:00pages
1225-38issue
8eissn
1742-5247issn
1744-7593journal_volume
12pub_type
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journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
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