Evaluation of material properties and compression characteristics of Assam Bora rice flours as a directly compressible vehicle in tablet formulation.

abstract：:Background: Atopic dermatitis is a chronic inflammatory skin disease that remarkably affects the quality-of-life of patients. Chamomile oil is used to treat skin inflammations. We evaluated the efficacy of chamomile oil and nanoemulgel formulations as a natural alternative therapeutic option for atopic dermatitis.Rese...

journal_title：Expert opinion on drug delivery

authors： El-Salamouni NS,Ali MM,Abdelhady SA,Kandil LS,Elbatouti GA,Farid RM

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Efficient and minimally invasive vector systems appear to be the most appropriate for both gene therapy and drug delivery. Numerous viral and non-viral vectors have been developed. Each vector has its own advantages and limitations. OBJECTIVE:New vectors have been required for overcoming the limitations of ...

journal_title：Expert opinion on drug delivery

authors： Kaneda Y

更新日期：2008-02-01 00:00:00

abstract：INTRODUCTION:Transportation of the nutrients and other substances from the blood to the brain is selectively controlled by the brain capillary endothelial cells that form a restrictive barrier, so-called blood-brain barrier (BBB). Currently, there is no unimpeachable approach to overcome the BBB obstructiveness because...

journal_title：Expert opinion on drug delivery

authors： Jafari B,Pourseif MM,Barar J,Rafi MA,Omidi Y

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Alendronate sodium (ALS) is the most common drug used for the treatment of osteoporosis. The challenges facing ALS use include: very poor oral bioavailability (0.6%), esophageal ulcers, and complicated instructions for its use. The objective of this research is to utilize nanotechnology to for...

journal_title：Expert opinion on drug delivery

authors： Hosny KM,Ahmed OA,Al-Abdali RT

更新日期：2013-06-01 00:00:00

abstract：INTRODUCTION:Gemcitabine, an anticancer drug, is a nucleoside analog deoxycytidine antimetabolite, which acts against a wide range of solid tumors. The limitation of gemcitabine is its rapid inactivation by the deoxycytidine deaminase enzyme following its in vivo administration. AREAS COVERED:One of the most promising...

journal_title：Expert opinion on drug delivery

authors： Celia C,Cosco D,Paolino D,Fresta M

更新日期：2011-12-01 00:00:00

abstract：INTRODUCTION:A major problem with conventional antitumor therapeutics is nonselective delivery of cytotoxic drugs to normal vital organs and tissues but little delivery to tumor tissues. AREAS COVERED:Here, the authors describe the tumor selective delivery of antitumor drugs by taking advantage of nano-sized drugs and...

journal_title：Expert opinion on drug delivery

authors： Nakamura H,Fang J,Maeda H

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Rapid clearance of drugs from the body results in short therapeutic half-life and is an integral property of many protein and peptide-based drugs. To maintain the desired therapeutic effect patients are required to administer higher doses more frequently, which is inconvenient and risks undesirable side ef...

journal_title：Expert opinion on drug delivery

authors： Sleep D

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Liposomes, phospholipids, nanosized bubbles with a bilayered membrane structure, have drawn a lot of interest as pharmaceutical carriers for drugs and genes. In particular, liposomes are widely used for drug delivery into tumors. OBJECTIVE:In many cases, to enhance the efficacy of the liposomal drugs, drug-...

journal_title：Expert opinion on drug delivery

authors： Torchilin V

更新日期：2008-09-01 00:00:00

abstract：:Functionalised carbon nanotubes (f-CNTs) are emerging as new tools in the field of nanobiotechnology and nanomedicine. This is because they can be easily manipulated and modified by encapsulation with biopolymers or by covalent linking of solubilising groups to the external walls and tips. The possibility of incorpora...

journal_title：Expert opinion on drug delivery

authors： Bianco A

更新日期：2004-11-01 00:00:00

abstract：:Targeting vaccines to the skin epidermis results in the activation of an immune inductive site that is rich in antigen-presenting cells. The superficial location of the skin makes it accessible to vaccine delivery. However, it is difficult to access the epidermis using needle and syringe delivery, and vaccine antigens...

journal_title：Expert opinion on drug delivery

authors： Dean HJ

更新日期：2005-03-01 00:00:00

abstract：INTRODUCTION:Drug release and oral absorption of drugs with pH-dependent solubility are influenced by the conditions in the gastrointestinal tract. In some cases, poor oral absorption has been observed for these drugs, causing insufficient drug efficacy. The pH-modification of a formulation could be a promising approac...

journal_title：Expert opinion on drug delivery

authors： Taniguchi C,Kawabata Y,Wada K,Yamada S,Onoue S

更新日期：2014-04-01 00:00:00

abstract：INTRODUCTION:Over the past several decades, liposomes have been used in a variety of applications, from delivery vehicles to cell membrane models. In terms of pharmaceutical use, they can offer control over the release of active agents encapsulated into their lipid bilayer or aqueous core, while providing protection fr...

journal_title：Expert opinion on drug delivery

authors： Bowey K,Tanguay JF,Tabrizian M

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVES:The aim of the present study is to evaluate the influence of factors such as biopharmaceutical properties and study protocol on the emptying of pellets from the human stomach in a fed state. METHODS:A systematic literature search for data on human gastric emptying of pellets from a fed stomach state investi...

journal_title：Expert opinion on drug delivery

authors： Bürmen B,Locatelli I,Mrhar A,Bogataj M

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:The distribution and metabolism of a drug in the organism are dependent on the administration route as well as on the drug formulation. It is important to be able to assess which impact the administration route or formulation of a drug has for its distribution and metabolism. METHODS:The antidepressant drug...

journal_title：Expert opinion on drug delivery

authors： Morineau L,Jacobsen SC,Kleberg K,Hansen HS,Janfelt C

更新日期：2018-12-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Cancer is the most formidable human disease. Owing to the heterogeneity of cancer, a single-treatment modality is insufficient for the complete elimination of cancer cells. Therapeutic strategies from various aspects are needed for cancer therapy. These therapeutic agents should be carefully sel...

journal_title：Expert opinion on drug delivery

authors： Kaneda Y

更新日期：2010-09-01 00:00:00

abstract：INTRODUCTION:Delivery of macromolecular drugs is an important field in medical research. However, macromolecules are usually unable to cross the cell membrane without the assistance of a delivery system. Cell penetrating peptides (CPPs) are unique tools to gain access to the cell interior and deliver a bioactive cargo ...

journal_title：Expert opinion on drug delivery

authors： Kurrikoff K,Gestin M,Langel Ü

更新日期：2016-01-01 00:00:00

abstract：:Due to the poor solvent properties of hydrofluoroalkanes, suspension is often the only formulation option for respiratory drug delivery. Research in this area has focussed mainly on two main themes over the past 5 years: new design of stabilisers and particle engineering. Among the most important advances, the introdu...

journal_title：Expert opinion on drug delivery

authors： Rogueda P

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:The lung comprises an interesting route of administration not only for topical drugs but also for systemically acting drugs. Over the last years, several models have been developed in order to study the efficacy and safety of pulmonary drug delivery. OBJECTIVE:This review describes relevant drug delivery mo...

journal_title：Expert opinion on drug delivery

authors： Fernandes CA,Vanbever R

更新日期：2009-11-01 00:00:00

abstract：:Objective: Conventional chloramphenicol (CHL) eye drops are widely used anti-infection formulations for acute bacterial conjunctivitis. However, the therapeutic effects are limited by insufficient concentration in the conjunctival sac. Hence, the objective of this study is to formulate and develop novel CHL eye drops ...

journal_title：Expert opinion on drug delivery

authors： Xu Y,Zhang C,Zhu X,Wang X,Wang H,Hu G,Fu Q,He Z

更新日期：2019-06-01 00:00:00

abstract：INTRODUCTION:A major problem in ocular therapeutics with classical formulations is the maintenance of an effective drug concentration at the site of action for a long period of time. Enhancement of ocular bioavailability with increased dose penetration and longer retention time at desired sites can be achieved by recen...

journal_title：Expert opinion on drug delivery

authors： Başaran E,Yazan Y

更新日期：2012-06-01 00:00:00

abstract：INTRODUCTION:Interest in mesoporous silica nanoparticles for drug delivery has resulted in a good understanding of the impact of size and surface chemistry of these nanoparticles on their performance as drug carriers. Shape has emerged as an additional factor that can have a significant effect on delivery efficacy. Rod...

journal_title：Expert opinion on drug delivery

authors： Cong VT,Gaus K,Tilley RD,Gooding JJ

更新日期：2018-09-01 00:00:00

abstract：INTRODUCTION:Hepatocellular carcinoma (HCC) is one of the most common lethal malignancies. The prognosis is poor despite progress in early diagnosis. The initial treatment of choice is hepatic resection; unfortunately, not all patients are eligible for liver resection. Moreover, there are significant recurrences. Diffe...

journal_title：Expert opinion on drug delivery

authors： Giunchedi P,Maestri M,Gavini E,Dionigi P,Rassu G

更新日期：2013-05-01 00:00:00

abstract：:The treatment of genetic diseases using therapeutic gene transfer is considered to be a significant development. This development has brought with it certain limitations, and the process of overcoming these barriers has seen a drastic change in gene delivery. Many metal ions such as Mg2+, Mn2+, Ba2+ and, most importan...

journal_title：Expert opinion on drug delivery

authors： Kulkarni VI,Shenoy VS,Dodiya SS,Rajyaguru TH,Murthy RR

更新日期：2006-03-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Since the 1950s, ultrasonic nebulizers have played an important role in pulmonary drug delivery. As the process in which aerosol droplets are generated is independent and does not require breath-actuation, ultrasonic nebulizers, in principle, offer the potential for instantaneously fine-tuning t...

journal_title：Expert opinion on drug delivery

authors： Yeo LY,Friend JR,McIntosh MP,Meeusen EN,Morton DA

更新日期：2010-06-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Spontaneously constructed from block copolymers in aqueous media, the polymer micelle has been extensively studied as a potential carrier of poorly water-soluble drugs, but cellular uptake pathways and stability of micelles in blood have not yet been clearly understood. An in-depth insight into ...

journal_title：Expert opinion on drug delivery

authors： Kim S,Shi Y,Kim JY,Park K,Cheng JX

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Long circulating liposomal drug carriers are widely used in experimental cancer therapy because they avoid excretion and benefit from the enhanced permeability and retention-effect to accumulate at the tumor site while simultaneously limiting systemic exposure to the cytotoxic drug due to their high stabil...

journal_title：Expert opinion on drug delivery

authors： Oude Blenke E,Mastrobattista E,Schiffelers RM

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVES:Methotrexate (MTX) is a chemotherapeutic and anti-inflammatory drug that may cause systemic adverse effects. This study investigated kinetics and biodistribution of MTX delivered topically by ablative fractional laser (AFXL). METHODS:In vitro passive diffusion of 10 mg/ml MTX (1 w/v%) was measured from 0.25...

journal_title：Expert opinion on drug delivery

authors： Taudorf EH,Lerche CM,Vissing AC,Philipsen PA,Hannibal J,D'Alvise J,Hansen SH,Janfelt C,Paasch U,Anderson RR,Haedersdal M

更新日期：2015-07-01 00:00:00

abstract：INTRODUCTION:Nanocomposite microparticles are intelligent carriers utilised for pulmonary drug delivery. These carriers are composed of drug-encapsulated nanoparticles dispersed in microstructures of polysaccharides. Upon administration, the inhaled microparticles can penetrate and be deposited deeply in the lung due t...

journal_title：Expert opinion on drug delivery

authors： Elsayed I,AbouGhaly MH

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Topically applied small interfering RNA (siRNA) can be an effective treatment for skin disorders. Using noninvasive strategies can be a safe and effective siRNA-permeation-enhancement approach for facilitating skin delivery. It has been demonstrated that noninvasive approaches for enhancing siRNA transport...

journal_title：Expert opinion on drug delivery

authors： Aljuffali IA,Lin YK,Fang JY

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Nanocarrier-based delivery systems offer multiple benefits to overcome limitations of the traditional drug dosage forms, such as protection of the drug, enhanced bioavailability, targeted delivery to disease site, etc. Nanocarriers have exhibited tremendous successes in targeted delivery of therapeutics to...

journal_title：Expert opinion on drug delivery

authors： Majumder J,Minko T

更新日期：2020-10-08 00:00:00