Peptide-mediated drug delivery across the blood-brain barrier for targeting brain tumors.

abstract：INTRODUCTION:Diseases of the inner ear include those of the auditory and vestibular systems, and frequently result in disabling hearing loss or vertigo. Despite a rapidly expanding pipeline of potential cochlear therapeutics, the inner ear remains a challenging organ for targeted drug delivery, and new technologies are...

journal_title：Expert opinion on drug delivery

authors： Ayoob AM,Borenstein JT

更新日期：2015-03-01 00:00:00

abstract：INTRODUCTION:In the therapy of clinical diseases such as cancer, it is important to deliver drugs directly to tumor sites in order to maximize local drug concentration and reduce side effects. This objective may be realized by using 'smart' nanoparticles (NPs) as drug delivery systems, because they enable dramatic conf...

journal_title：Expert opinion on drug delivery

authors： Fang Z,Wan LY,Chu LY,Zhang YQ,Wu JF

更新日期：2015-01-01 00:00:00

abstract：:The demand for new vaccine adjuvants is well documented. New purified antigens from parasites, bacterial or viral pathogens, as well as recombinant subunit antigens and synthetic peptides, are often inherently weak immunogens; therefore, they need some kind of adjuvant to help initiate an immune response. In addition,...

journal_title：Expert opinion on drug delivery

authors： Rydell N,Stertman L,Sjöholm I

更新日期：2005-09-01 00:00:00

abstract：INTRODUCTION:Rapid clearance of drugs from the body results in short therapeutic half-life and is an integral property of many protein and peptide-based drugs. To maintain the desired therapeutic effect patients are required to administer higher doses more frequently, which is inconvenient and risks undesirable side ef...

journal_title：Expert opinion on drug delivery

authors： Sleep D

更新日期：2015-05-01 00:00:00

abstract：INTRODUCTION:Macrophages are involved in the normal defense of the body; however, the varying phenotypes of macrophages and imbalance in their ratio lead to the impairment of immune response initiating the production of inflammation. As the role of macrophages in immunological disorders and their surface receptors modu...

journal_title：Expert opinion on drug delivery

authors： Mukhtar M,Ali H,Ahmed N,Munir R,Talib S,Khan AS,Ambrus R

更新日期：2020-09-01 00:00:00

abstract：INTRODUCTION:Nanocomposite microparticles are intelligent carriers utilised for pulmonary drug delivery. These carriers are composed of drug-encapsulated nanoparticles dispersed in microstructures of polysaccharides. Upon administration, the inhaled microparticles can penetrate and be deposited deeply in the lung due t...

journal_title：Expert opinion on drug delivery

authors： Elsayed I,AbouGhaly MH

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Gemcitabine, an anticancer drug, is a nucleoside analog deoxycytidine antimetabolite, which acts against a wide range of solid tumors. The limitation of gemcitabine is its rapid inactivation by the deoxycytidine deaminase enzyme following its in vivo administration. AREAS COVERED:One of the most promising...

journal_title：Expert opinion on drug delivery

authors： Celia C,Cosco D,Paolino D,Fresta M

更新日期：2011-12-01 00:00:00

abstract：INTRODUCTION:Delivery of macromolecular drugs is an important field in medical research. However, macromolecules are usually unable to cross the cell membrane without the assistance of a delivery system. Cell penetrating peptides (CPPs) are unique tools to gain access to the cell interior and deliver a bioactive cargo ...

journal_title：Expert opinion on drug delivery

authors： Kurrikoff K,Gestin M,Langel Ü

更新日期：2016-01-01 00:00:00

abstract：:This review article provides an assessment of advantages/limitations of the use of current in vitro release models to predict in vivo performance of parenteral sustained release products (injectable depots). As highlighted, key characteristics influencing the in vivo drug fate may vary with the route of administration...

journal_title：Expert opinion on drug delivery

authors： Larsen C,Larsen SW,Jensen H,Yaghmur A,Ostergaard J

更新日期：2009-12-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Efficient systemic delivery of low-molecular-mass therapeutics to neuronal tissue remains a central issue not only to drug development but also to the chronic treatment of a range of neurodegenerative disorders. AREAS COVERED IN THIS REVIEW:This review discusses the potential of using RNA inter...

journal_title：Expert opinion on drug delivery

authors： Campbell M,Ozaki E,Humphries P

更新日期：2010-07-01 00:00:00

abstract：INTRODUCTION:Many new drug substances have low aqueous solubility which can cause poor bioavailability after oral administration. The application of solid dispersions is a useful method to increase the dissolution rate of these drugs and thereby improve their bioavailability. So far, several methods have been developed...

journal_title：Expert opinion on drug delivery

authors： Srinarong P,de Waard H,Frijlink HW,Hinrichs WL

更新日期：2011-09-01 00:00:00

abstract：INTRODUCTION:Superparamagnetic iron oxide nanoparticle (SPION)-based carrier systems have many advantages over other nanoparticle-based systems. They are biocompatible, biodegradable, facilely tunable and superparamagnetic and thus controllable by an external magnetic field. These attributes enable their broad biomedic...

journal_title：Expert opinion on drug delivery

authors： Mok H,Zhang M

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:This study focuses on the development of amlodipine bilayer buccal tablets of hydroxypropyl methylcellulose (HPMC) matrix system containing polyacrylate polymer (Carbopol(®))/β-cyclodextrin as the drug layer and ethylcellulose as the non-swellable backing layer, and their biointerfacial phenomena. METHODS:T...

journal_title：Expert opinion on drug delivery

authors： Panda B,Subhadarsini R,Mallick S

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to improve the drug loading (DL) and stability of clarithromycin (CLA)-loaded liposomes, and reduce the irritation caused by intravenous administration of CLA. METHODS:A CLA-cholesteryl hemisuccinate (CHEMS) ion pair (CIP) was prepared by the solvent evaporation method and confirmed...

journal_title：Expert opinion on drug delivery

authors： Geng S,Liu X,Xu H,Cai C,Zhang Y,Yao Q,Xu H,Gou J,Yin T,Xiao W,Tang X

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Liposomes, phospholipids, nanosized bubbles with a bilayered membrane structure, have drawn a lot of interest as pharmaceutical carriers for drugs and genes. In particular, liposomes are widely used for drug delivery into tumors. OBJECTIVE:In many cases, to enhance the efficacy of the liposomal drugs, drug-...

journal_title：Expert opinion on drug delivery

authors： Torchilin V

更新日期：2008-09-01 00:00:00

abstract：:Introduction: Cisplatin has been indicated for several malignancies all over the world for many years. Increasing patient tolerance for high dose of chemotherapeutics and reducing side effects has been granted by drug encapsulated liposomal systems. There have been much efforts for improving cisplatin delivery to the ...

journal_title：Expert opinion on drug delivery

authors： Zahednezhad F,Zakeri-Milani P,Shahbazi Mojarrad J,Valizadeh H

更新日期：2020-04-01 00:00:00

abstract：INTRODUCTION:With the incorporation of edge activators into the lipid bilayer structure, elasticity properties are given to liposomes. Regardless of the debate over the precise permeation mechanism of elastic liposomes, these vesicles have been proven to enhance drug permeation into or through skin in most cases. AREA...

journal_title：Expert opinion on drug delivery

authors： Chen J,Lu WL,Gu W,Lu SS,Chen ZP,Cai BC

更新日期：2013-06-01 00:00:00

abstract：INTRODUCTION:This topic is important as it allows for improved specificity in drug delivery, providing possibilities for reduced side effects, and thereby improved pharmacotherapy. As a wealth of different polymers and mechanisms of action has been suggested, a systematic overview of the field is of current importance....

journal_title：Expert opinion on drug delivery

authors： Calejo MT,Sande SA,Nyström B

更新日期：2013-12-01 00:00:00

abstract：:Many agents used to treat cancer are toxic to normal tissues. Thus, treatments delivering drug specifically to tumour, while minimising exposure to normal tissue, may be advantageous over non-targeted treatments. The exquisite specificity of the immune system has been used successfully to help develop targeted antican...

journal_title：Expert opinion on drug delivery

authors： Brumlik MJ,Daniel BJ,Waehler R,Curiel DT,Giles FJ,Curiel TJ

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Sixty years since its introduction, 5-FU still forms the core of chemotherapy regimens for many types of malignancies. 5-FU is a time-dependent drug but is rapidly degraded in plasma by dihydropyrimidine dehydrogenase (DPD). Although originally developed in an intravenous form, 5-FU oral prodrugs were deve...

journal_title：Expert opinion on drug delivery

authors： Miura K,Shima H,Takebe N,Rhie J,Satoh K,Kakugawa Y,Satoh M,Kinouchi M,Yamamoto K,Hasegawa Y,Kawai M,Kanazawa K,Fujiya T,Unno M,Katakura R

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:Test the hypothesis that pegylated meglumine antimoniate-containing liposomes (LMA) and their mixture with non-pegylated (conventional) LMA may be more effective than conventional LMA against visceral leishmaniasis (VL), because of wider drug distribution among different mononuclear phagocyte system (MPS) tis...

journal_title：Expert opinion on drug delivery

authors： Azevedo EG,Ribeiro RR,da Silva SM,Ferreira CS,de Souza LE,Ferreira AA,de Oliveira E Castro RA,Demicheli C,Rezende SA,Frézard F

更新日期：2014-10-01 00:00:00

abstract：AIM:The mechanical properties and compaction characteristics of different varieties of Assam Bora rice flours (ABRFs) were evaluated and compared with those of official Starch 1500®. METHODS:The material properties and compression characteristics of Assam Bora rice flours were studied by Heckel and Kawakita analysis. ...

journal_title：Expert opinion on drug delivery

authors： Ahmad MZ,Akhter S,Dhiman I,Sharma P,Verma R

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:We hypothesized if phagocytosis of liposomes by macrophages could be mitigated through incorporation of a CD47 mimicry peptide (Self peptide: SP) on the surface of liposomes. METHODS:Thin film hydration method followed by extrusion was used to prepare nanoliposomes, and Dox encapsulation in liposomes was do...

journal_title：Expert opinion on drug delivery

authors： Gheibi Hayat SM,Jaafari MR,Hatamipour M,Jamialahmadi T,Sahebkar A

更新日期：2020-07-01 00:00:00

abstract：INTRODUCTION:Inflammatory bowel disease (IBD) is an exceptional scenario with regard to drug targeting, as oral administration has the potential to deliver the drug directly to the site(s) of action. Consequently, retention of the drug within the intestinal lumen and tissue, rather than systemic absorption, is frequent...

journal_title：Expert opinion on drug delivery

authors： Wolk O,Epstein S,Ioffe-Dahan V,Ben-Shabat S,Dahan A

更新日期：2013-09-01 00:00:00

abstract：INTRODUCTION:Transdermal drug delivery has several known advantages over the oral route and hypodermic injections. The number of drugs that can be taken up transdermally is, however, limited owing to the innate barrier function of the skin. New transdermal drug candidates need to be tested extensively before being used...

journal_title：Expert opinion on drug delivery

authors： Van Gele M,Geusens B,Brochez L,Speeckaert R,Lambert J

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Pulmonary cell culture models for the development of new aerosol medicines are attracting increasing interest. Ease of handling, ethical acceptance and high explanatory power are the main advantages of cell culture systems in pulmonary drug research. OBJECTIVE:Pulmonary cell culture models are described and...

journal_title：Expert opinion on drug delivery

authors： Bur M,Lehr CM

更新日期：2008-06-01 00:00:00

abstract：:Introduction: Pulmonary drug delivery is a complex field of research combining physics which drive aerosol transport and deposition and biology which underpins efficacy and toxicity of inhaled drugs. A myriad of preclinical methods, ranging from in-silico to in-vitro, ex-vivo and in-vivo, can be implemented.Areas cove...

journal_title：Expert opinion on drug delivery

authors： Ehrmann S,Schmid O,Darquenne C,Rothen-Rutishauser B,Sznitman J,Yang L,Barosova H,Vecellio L,Mitchell J,Heuze-Vourc'h N

更新日期：2020-04-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Spontaneously constructed from block copolymers in aqueous media, the polymer micelle has been extensively studied as a potential carrier of poorly water-soluble drugs, but cellular uptake pathways and stability of micelles in blood have not yet been clearly understood. An in-depth insight into ...

journal_title：Expert opinion on drug delivery

authors： Kim S,Shi Y,Kim JY,Park K,Cheng JX

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Bisphosphonates (BPs) were introduced 45 years ago as anti-osteoporotic drugs and during the last decade have been utilized as bone-targeting groups in systemic treatment of bone diseases. Very recently, strategies of chemical immobilization of BPs in hydrogels and nanocomposites for bone tissue engineerin...

journal_title：Expert opinion on drug delivery

authors： Ossipov DA

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Interest in mesoporous silica nanoparticles for drug delivery has resulted in a good understanding of the impact of size and surface chemistry of these nanoparticles on their performance as drug carriers. Shape has emerged as an additional factor that can have a significant effect on delivery efficacy. Rod...

journal_title：Expert opinion on drug delivery

authors： Cong VT,Gaus K,Tilley RD,Gooding JJ

更新日期：2018-09-01 00:00:00