Biointerfacial phenomena of amlodipine buccomucosal tablets of HPMC matrix system containing polyacrylate polymer/β-cyclodextrin: Correlation of swelling and drug delivery performance.

abstract：INTRODUCTION:Topically applied small interfering RNA (siRNA) can be an effective treatment for skin disorders. Using noninvasive strategies can be a safe and effective siRNA-permeation-enhancement approach for facilitating skin delivery. It has been demonstrated that noninvasive approaches for enhancing siRNA transport...

journal_title：Expert opinion on drug delivery

authors： Aljuffali IA,Lin YK,Fang JY

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Pulmonary cell culture models for the development of new aerosol medicines are attracting increasing interest. Ease of handling, ethical acceptance and high explanatory power are the main advantages of cell culture systems in pulmonary drug research. OBJECTIVE:Pulmonary cell culture models are described and...

journal_title：Expert opinion on drug delivery

authors： Bur M,Lehr CM

更新日期：2008-06-01 00:00:00

abstract：INTRODUCTION:In any manufacturing process, the success of producing an end product with the desired properties and yield depends on a range of factors that include the equipment, process and formulation variables. It is the interest of manufacturers and researchers to understand each manufacturing process better and as...

journal_title：Expert opinion on drug delivery

authors： Oh CM,Guo Q,Wan Sia Heng P,Chan LW

更新日期：2014-07-01 00:00:00

abstract：INTRODUCTION:Liposomes are well-known as drug carriers, and are now critical components of two of six types of adjuvants present in licensed vaccines. The liposomal vaccine adjuvant field has long been dynamic and innovative, and research in this area is further examined as new commercial products appear in parallel wi...

journal_title：Expert opinion on drug delivery

authors： Alving CR,Beck Z,Matyas GR,Rao M

更新日期：2016-06-01 00:00:00

abstract：INTRODUCTION:Cancer initiating or stem cells (CSCs) are a small population of cells in the tumor mass, which have been reported to be present in different types of cancers. CSCs usually reside within the tumor and are responsible for reoccurrence of cancer. The imprecise, inaccessible nature and increased efflux of con...

journal_title：Expert opinion on drug delivery

authors： Ahmad G,Amiji MM

更新日期：2017-08-01 00:00:00

abstract：:Introduction: Current therapies of neurodegenerative or neurometabolic diseases are, to a large extent, hampered by the inability of drugs to cross the blood-brain barrier (BBB). This very tight barrier severely restricts the entrance of molecules from the blood into the brain, especially macromolecular substances (i....

journal_title：Expert opinion on drug delivery

authors： Tosi G,Duskey JT,Kreuter J

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Nanocarrier-based delivery systems offer multiple benefits to overcome limitations of the traditional drug dosage forms, such as protection of the drug, enhanced bioavailability, targeted delivery to disease site, etc. Nanocarriers have exhibited tremendous successes in targeted delivery of therapeutics to...

journal_title：Expert opinion on drug delivery

authors： Majumder J,Minko T

更新日期：2020-10-08 00:00:00

abstract：:The field of infectious diseases is in crisis and there is a need for strategies that can facilitate the rapid development of new antimicrobial agents. Radioimmunotherapy (RIT), a therapeutic modality originally developed for cancer treatment, has recently been suggested as a novel therapy for the treatment of a varie...

journal_title：Expert opinion on drug delivery

authors： Dadachova E,Casadevall A

更新日期：2005-11-01 00:00:00

abstract：:Skin diseases are prevalent and can significantly affect quality of life. Empirical mathematical models retrospectively analyse data to predict skin permeation from the physico-chemical properties of drugs. Quantitative structure permeability relationships are discussed, along with alternatives to linear modelling. Me...

journal_title：Expert opinion on drug delivery

authors： Russell LM,Guy RH

更新日期：2009-04-01 00:00:00

abstract：:Beta-adrenoceptor blocking drugs (beta-blockers) are one of the most frequently used class of cardiovascular drugs that are mainly used in conventional dosage forms., which have their own limitations including hepatic first-pass metabolism, high incidence of adverse effects due to variable absorption profiles, higher ...

journal_title：Expert opinion on drug delivery

authors： Aqil M,Sultana Y,Ali A

更新日期：2006-05-01 00:00:00

abstract：INTRODUCTION:Recent advances in pharmacological therapies to treat ocular diseases such as glaucoma, age-related macular degeneration, diabetic macular edema and retinal vascular occlusions have greatly improved the prognosis for these diseases. Due to these advances in pharmacological therapy, there is a great deal of...

journal_title：Expert opinion on drug delivery

authors： Kang-Mieler JJ,Osswald CR,Mieler WF

更新日期：2014-10-01 00:00:00

abstract：:Background: Anti-tumor necrosis factor (anti-TNF) adherence is suboptimal. ava®, a reusable electromechanical self-injection device (e-Device) developed for certolizumab pegol (CZP) administration, aims to overcome some barriers to increase adherence. This study evaluates patient experience of the e-Device and its tra...

journal_title：Expert opinion on drug delivery

authors： Pouls BPH,Kristensen LE,Petersson M,van den Bemt BJF,Ballerini L,Bruggraber R,Karlen H,Mountian I,van Bracht E,Wiegratz S,Jørgensen TS

更新日期：2020-05-01 00:00:00

abstract：INTRODUCTION:With the incorporation of edge activators into the lipid bilayer structure, elasticity properties are given to liposomes. Regardless of the debate over the precise permeation mechanism of elastic liposomes, these vesicles have been proven to enhance drug permeation into or through skin in most cases. AREA...

journal_title：Expert opinion on drug delivery

authors： Chen J,Lu WL,Gu W,Lu SS,Chen ZP,Cai BC

更新日期：2013-06-01 00:00:00

abstract：INTRODUCTION:Diabetic Retinopathy (DR) is one of the most common causes of blindness among the working population worldwide. Clearly, there is an unmet clinical need to find better treatment options for DR. Areas covered: The literature search was conducted on PubMed with no limitation on language or year of publicatio...

journal_title：Expert opinion on drug delivery

authors： Nirmal J,Radhakrishnan K,Moreno M,Natarajan JV,Laude A,Lim TH,Venkatraman S,Agrawal R

更新日期：2016-11-01 00:00:00

abstract：INTRODUCTION:Oral delivery of therapeutic peptide hormones offers the promise of greater patient compliance when compared to parenteral administration routes. However, it is a huge challenge in the pharmaceutical field. Due to increasing demand for oral delivery of peptide hormones such as insulin, gonadotropin-releasi...

journal_title：Expert opinion on drug delivery

authors： Varamini P,Toth I

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Oxidative stress has generally been recognized as an important factor in the pathogenesis of human diseases, making antioxidant therapy a plausible strategy to either prevent or treat human disorders. Yet so far, numerous antioxidant-based clinical trials aimed at developing clinically approved protocols h...

journal_title：Expert opinion on drug delivery

authors： Weissig V,Guzman-Villanueva D

更新日期：2015-01-01 00:00:00

abstract：:Introduction: Pulmonary drug delivery is a complex field of research combining physics which drive aerosol transport and deposition and biology which underpins efficacy and toxicity of inhaled drugs. A myriad of preclinical methods, ranging from in-silico to in-vitro, ex-vivo and in-vivo, can be implemented.Areas cove...

journal_title：Expert opinion on drug delivery

authors： Ehrmann S,Schmid O,Darquenne C,Rothen-Rutishauser B,Sznitman J,Yang L,Barosova H,Vecellio L,Mitchell J,Heuze-Vourc'h N

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:The present work aims to formulate nanostructured lipid carriers (NLCs) exhibiting high skin deposition and high inherent antioxidant potential to repurpose the use of melatonin hormone and some antioxidant oils in the treatment of androgenic alopecia (AGA). RESEARCH DESIGN AND METHODS:NLCs were characteriz...

journal_title：Expert opinion on drug delivery

authors： Hatem S,Nasr M,Moftah NH,Ragai MH,Geneidi AS,Elkheshen SA

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:Delivery of macromolecular drugs is an important field in medical research. However, macromolecules are usually unable to cross the cell membrane without the assistance of a delivery system. Cell penetrating peptides (CPPs) are unique tools to gain access to the cell interior and deliver a bioactive cargo ...

journal_title：Expert opinion on drug delivery

authors： Kurrikoff K,Gestin M,Langel Ü

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:Test the hypothesis that pegylated meglumine antimoniate-containing liposomes (LMA) and their mixture with non-pegylated (conventional) LMA may be more effective than conventional LMA against visceral leishmaniasis (VL), because of wider drug distribution among different mononuclear phagocyte system (MPS) tis...

journal_title：Expert opinion on drug delivery

authors： Azevedo EG,Ribeiro RR,da Silva SM,Ferreira CS,de Souza LE,Ferreira AA,de Oliveira E Castro RA,Demicheli C,Rezende SA,Frézard F

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:Ultrasound enhancement of thrombolysis (sonothrombolysis) is further potentiated by administration of acoustically active microbubbles, which may be developed into powerful adjuvant therapies for thrombolytic treatment of occlusive conditions such as ischaemic stroke. AREAS COVERED:The role of microbubble...

journal_title：Expert opinion on drug delivery

authors： de Saint Victor M,Crake C,Coussios CC,Stride E

更新日期：2014-02-01 00:00:00

abstract：INTRODUCTION:The use of hydrophilic polymers as a substitute for the Fc-domain in immuno- or non-immuno-based binding proteins is accelerating. Chemical PEGylation has led the way and is still the most advanced and clinically-approved approach. Hydrophilic polymers act by maintaining a flexible conformation and hydroge...

journal_title：Expert opinion on drug delivery

authors： Chen C,Constantinou A,Deonarain M

更新日期：2011-09-01 00:00:00

abstract：INTRODUCTION:Overexpression of VEGF has been identified to be associated with many pathologic processes such as tumors and retinopathy. Inhibiting uncontrolled growth of VEGF is a promising strategy to treat these diseases. Currently small molecule inhibitors and monoclonal antibodies are the primary treatment. However...

journal_title：Expert opinion on drug delivery

authors： Chen S,Feng J,Ma L,Liu Z,Yuan W

更新日期：2014-09-01 00:00:00

abstract：INTRODUCTION:Inflammatory bowel disease (IBD) is a chronic autoimmune disease, whose main forms are Crohn's disease and ulcerative colitis. The main treatment of IBD includes oral administration of anti-inflammatory or immunosuppressive agents enclosed in traditional dosage forms, intended to release the active ingredi...

journal_title：Expert opinion on drug delivery

authors： Youshia J,Lamprecht A

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Rapid clearance of drugs from the body results in short therapeutic half-life and is an integral property of many protein and peptide-based drugs. To maintain the desired therapeutic effect patients are required to administer higher doses more frequently, which is inconvenient and risks undesirable side ef...

journal_title：Expert opinion on drug delivery

authors： Sleep D

更新日期：2015-05-01 00:00:00

abstract：INTRODUCTION:Simvastatin (SV) is a drug from the statin class, currently used orally as an anti-cholesterolemic drug. It inhibits the 3-hydroxy-3-methyl-glutaryl-Coenzyme A (HMG-CoA) reductase to reduce cholesterol synthesis. Recently, it has been found that SV also has several other protective pharmacological actions ...

journal_title：Expert opinion on drug delivery

authors： Tulbah AS,Ong HX,Colombo P,Young PM,Traini D

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:The distribution and metabolism of a drug in the organism are dependent on the administration route as well as on the drug formulation. It is important to be able to assess which impact the administration route or formulation of a drug has for its distribution and metabolism. METHODS:The antidepressant drug...

journal_title：Expert opinion on drug delivery

authors： Morineau L,Jacobsen SC,Kleberg K,Hansen HS,Janfelt C

更新日期：2018-12-01 00:00:00

abstract：INTRODUCTION:Apart from statins, anti-platelet agents and invasive procedures, the anti-atherosclerotic medical weaponry for coronary heart disease (CHD) is scarce and only partially protects CHD patients from major adverse cardiac events. AREAS COVERED:Several novel non-invasive strategies are being developed to wide...

journal_title：Expert opinion on drug delivery

authors： Maranhão RC,Tavares ER

更新日期：2015-07-01 00:00:00

abstract：:The advent of sophisticated drug delivery strategies for cancer applications has inundated the scientific and clinical community with new tactics and approaches such as molecular targeting, nanotechnology-based methods and personalized therapies. Unfortunately, the clinical impact has been moderate at best, falling si...

journal_title：Expert opinion on drug delivery

authors： Sakamoto J,Annapragada A,Decuzzi P,Ferrari M

更新日期：2007-07-01 00:00:00

abstract：INTRODUCTION:Considering that the number of patients afflicted by posterior eye diseases is increasing, effective drug delivery is currently in high clinical demand. Topical administration has been identified as the preferred option, while sufferingfrom multiple barriers. The development of nanoparticle-based drug deli...

journal_title：Expert opinion on drug delivery

authors： Wang Y,Xu X,Gu Y,Cheng Y,Cao F

更新日期：2018-07-01 00:00:00