Abstract:
INTRODUCTION:Interest in mesoporous silica nanoparticles for drug delivery has resulted in a good understanding of the impact of size and surface chemistry of these nanoparticles on their performance as drug carriers. Shape has emerged as an additional factor that can have a significant effect on delivery efficacy. Rod-shaped mesoporous silica nanoparticles show improvements in drug delivery relative to spherical mesoporous silica nanoparticles. AREAS COVERED:This review summarises the synthesis methods for producing rod-shaped mesoporous silica nanoparticles for use in nanomedicine. The second part covers recent progress of mesoporous silica nanorods by comparing the impact of sphere and rod-shape on drug delivery efficiency. EXPERT OPINION:As hollow mesoporous silica nanorods are capable of higher drug loads than most other drug delivery vehicles, such particles will reduce the amount of mesoporous silica in the body for efficient therapy. However, the importance of nanoparticle shape on drug delivery efficiency is not well understood for mesoporous silica. Studies that visualize and quantify the uptake pathway of mesoporous silica nanorods in specific cell types and compare the cellular uptake to the well-studied nanospheres should be the focus of research to better understand the role of shape in uptake.
journal_name
Expert Opin Drug Delivjournal_title
Expert opinion on drug deliveryauthors
Cong VT,Gaus K,Tilley RD,Gooding JJdoi
10.1080/17425247.2018.1517748subject
Has Abstractpub_date
2018-09-01 00:00:00pages
881-892issue
9eissn
1742-5247issn
1744-7593journal_volume
15pub_type
杂志文章,评审abstract:INTRODUCTION:Currently, hot melt extrusion (HME) is a promising technology in the pharmaceutical industry, as evidenced by its application to manufacture various FDA-approved commercial products in the market. HME is extensively researched for enhancing the solubility and bioavailability of poor water-soluble drugs, ta...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1080/17425247.2019.1609448
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abstract::Introduction: Making selective inhibitors of novel Gram-negative targets is not a substantial challenge - getting them into Gram-negative bacteria to reach their lethal target is the bottleneck. Poor permeability of the antibiotic requires high concentration causing off target activity. The lack of simple experimental...
journal_title:Expert opinion on drug delivery
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abstract:INTRODUCTION:Drug release and oral absorption of drugs with pH-dependent solubility are influenced by the conditions in the gastrointestinal tract. In some cases, poor oral absorption has been observed for these drugs, causing insufficient drug efficacy. The pH-modification of a formulation could be a promising approac...
journal_title:Expert opinion on drug delivery
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doi:10.1517/17425247.2014.881798
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abstract:INTRODUCTION:The development of therapeutics for central nervous system (CNS) disorders is still considered a challenging area in drug development due to insufficient translocation through the blood-brain barrier (BBB). Under normal conditions, BBB restrict the penetration of more than 98% of blood-borne molecules incl...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1080/17425247.2018.1444601
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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abstract::The demand for new vaccine adjuvants is well documented. New purified antigens from parasites, bacterial or viral pathogens, as well as recombinant subunit antigens and synthetic peptides, are often inherently weak immunogens; therefore, they need some kind of adjuvant to help initiate an immune response. In addition,...
journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
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doi:10.1517/17425247.2013.799136
更新日期:2013-06-01 00:00:00
abstract:INTRODUCTION:Skin disorders will continue to cause complications in patients. At present, there is an expansion of research into dermatologic treatment due to a critical need for new treatment options to treat skin diseases. AREAS COVERED:The skin itself provides a natural barrier against particle penetration for topi...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2012.686490
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abstract::Skin diseases are prevalent and can significantly affect quality of life. Empirical mathematical models retrospectively analyse data to predict skin permeation from the physico-chemical properties of drugs. Quantitative structure permeability relationships are discussed, along with alternatives to linear modelling. Me...
journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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更新日期:2008-08-01 00:00:00
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.5.4.371
更新日期:2008-04-01 00:00:00
abstract:INTRODUCTION:Research into oral delivery of biologics has a long and rich history but has not produced technologies used in the clinic. The area has evolved in terms of strategies to promote oral biologics delivery from early chemical absorption enhancers to nanomedicine to devices. Continued activity in this area is j...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1080/17425247.2018.1504017
更新日期:2018-08-01 00:00:00
abstract:INTRODUCTION:The use of hydrophilic polymers as a substitute for the Fc-domain in immuno- or non-immuno-based binding proteins is accelerating. Chemical PEGylation has led the way and is still the most advanced and clinically-approved approach. Hydrophilic polymers act by maintaining a flexible conformation and hydroge...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2011.602399
更新日期:2011-09-01 00:00:00
abstract:INTRODUCTION:Management of Osteoarthritis (OA) still is a challenge for clinicians. Taking into account a multidisciplinary approach including pharmacological and non-pharmacological treatments, intra-articular (IA) injection could be considered as an effective local therapy. Areas covered This review provides a new pe...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
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更新日期:2015-07-01 00:00:00
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journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
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doi:10.1517/17425247.2012.636801
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journal_title:Expert opinion on drug delivery
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