Novel functionalization strategies to improve drug delivery from polymers.


INTRODUCTION:The utility of controlled and sustained release of drugs from polymeric systems, both bulk (hydrogels) and colloids (nanoparticles), is a key point that should be addressed. Unfortunately, classic delivery systems are essentially driven by diffusion, which is very quick due to the high concentration gradient present in the body. Area covered: This review provides an overview of functionalization strategies which have been used to reduce release rates by taking advantage of post-polymerization functionalization of polymers. This paradigm is extremely useful in the pharmacological treatment of several diseases, particularly multifactorial diseases, which may require a variety of release kinetics for different drugs from a single device. Expert opinion: Polymer chains can be functionalized with several post-polymerization strategies in order to link, with a cleavable bond, drug molecules to reactive points of the polymeric network. Following this strategy, the main mechanism related to drug release is the breakage of the link that could be opportunely chosen depending on the medical needs: the weaker the bond, the higher the release rate.


Expert Opin Drug Deliv


Mauri E,Papa S,Masi M,Veglianese P,Rossi F




Has Abstract


2017-11-01 00:00:00












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    authors: Chandrasekhar S,Iyer LK,Panchal JP,Topp EM,Cannon JB,Ranade VV

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  • Nucleic acid-loaded lipid-polymer nanohybrids as novel nanotherapeutics in anticancer therapy.

    abstract:INTRODUCTION:Since decades, cancer is a major public health problem worldwide. The increasing knowledge of molecular and tumor biology has significantly changed the cancer treatment paradigms during the past few years. AREA COVERED:Conventionally, the first-line treatment of solid tumors is their surgical removal foll...

    journal_title:Expert opinion on drug delivery

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    abstract:INTRODUCTION:Liposomes are well-known as drug carriers, and are now critical components of two of six types of adjuvants present in licensed vaccines. The liposomal vaccine adjuvant field has long been dynamic and innovative, and research in this area is further examined as new commercial products appear in parallel wi...

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    authors: Alving CR,Beck Z,Matyas GR,Rao M

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  • Pulmonary delivery of anti-inflammatory agents.

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    abstract:INTRODUCTION:Bisphosphonates (BPs) were introduced 45 years ago as anti-osteoporotic drugs and during the last decade have been utilized as bone-targeting groups in systemic treatment of bone diseases. Very recently, strategies of chemical immobilization of BPs in hydrogels and nanocomposites for bone tissue engineerin...

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    pub_type: 杂志文章,评审


    authors: Ossipov DA

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    authors: Brenner JS,Greineder C,Shuvaev V,Muzykantov V

    更新日期:2015-02-01 00:00:00

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    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审


    authors: Pather SI,Rathbone MJ,Senel S

    更新日期:2008-05-01 00:00:00

  • Recent updates in utilizing prodrugs in drug delivery (2013-2015).

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    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审


    authors: Varshosaz J

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    更新日期:2015-07-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Sriamornsak P

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    abstract:AIM:The mechanical properties and compaction characteristics of different varieties of Assam Bora rice flours (ABRFs) were evaluated and compared with those of official Starch 1500®. METHODS:The material properties and compression characteristics of Assam Bora rice flours were studied by Heckel and Kawakita analysis. ...

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    pub_type: 杂志文章


    authors: Ahmad MZ,Akhter S,Dhiman I,Sharma P,Verma R

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    abstract:BACKGROUND:Augmentation of simvastatin (SMV) cytotoxicity in breast carcinoma cell lines MCF-7, by: improvement of cellular uptake and loading on alpha lipoic acid (ALA). METHODS:In this study, SMV was loaded on ALA nanoparticles and characterized for surface morphology, SMV entrapment efficiency percent (%EE), zeta p...

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    pub_type: 杂志文章,评审


    authors: Vllasaliu D,Thanou M,Stolnik S,Fowler R

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  • Thermoresponsive polymers as gene and drug delivery vectors: architecture and mechanism of action.

    abstract:INTRODUCTION:This topic is important as it allows for improved specificity in drug delivery, providing possibilities for reduced side effects, and thereby improved pharmacotherapy. As a wealth of different polymers and mechanisms of action has been suggested, a systematic overview of the field is of current importance....

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    authors: Calejo MT,Sande SA,Nyström B

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  • Recent advances in the targeting of systemically administered non-viral gene delivery systems.

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    authors: Khalil IA,Sato Y,Harashima H

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  • The use of reversible addition fragmentation chain transfer polymerization for drug delivery systems.

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    authors: Gregory A,Stenzel MH

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  • Recent advances in polymeric microspheres for parenteral drug delivery--part 1.

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    pub_type: 杂志文章,评审


    authors: Mao S,Guo C,Shi Y,Li LC

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    authors: Pang X,Yang X,Zhai G

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    abstract:BACKGROUND AND OBJECTIVES:Alendronate sodium (ALS) is the most common drug used for the treatment of osteoporosis. The challenges facing ALS use include: very poor oral bioavailability (0.6%), esophageal ulcers, and complicated instructions for its use. The objective of this research is to utilize nanotechnology to for...

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    authors: Hosny KM,Ahmed OA,Al-Abdali RT

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  • Targeting drugs to the airways: The role of spacer devices.

    abstract:AIM:Spacer devices are inhalation aids of varying dimension and complexity, specifically designed to overcome problems with the use of pressurised metered dose inhalers (pMDIs). The aim of this review is to examine the current understanding about these inhalation devices and discuss their advantages and disadvantages. ...

    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审


    authors: Lavorini F,Fontana GA

    更新日期:2009-01-01 00:00:00

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    authors: Tan YF,Lee YS,Seet LF,Ng KW,Wong TT,Venkatraman S

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    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审


    authors: Cong VT,Gaus K,Tilley RD,Gooding JJ

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    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章,评审


    authors: Al-Ahmady ZS

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    journal_title:Expert opinion on drug delivery

    pub_type: 杂志文章


    authors: Panda B,Subhadarsini R,Mallick S

    更新日期:2016-01-01 00:00:00

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    journal_title:Expert opinion on drug delivery

    pub_type: 社论


    authors: Patel MM

    更新日期:2011-10-01 00:00:00