Abstract:
:Oral colon-targeted drug delivery systems have gained enormous attention among researchers in the last two decades. The significance of this site-specific drug delivery system can be measured by its usefulness for delivering a variety of therapeutic agents, both for the treatment of local diseases or for systemic therapies. With the arrival of newer innovations, a large number of breakthrough technologies have emerged for targeting a drug molecule to the colon. Researchers have attempted various approaches in the development of these formulation technologies, such as pH-dependent, time-dependent and microflora-activated systems. Recently, a number of approaches have been proposed that utilize a novel concept of di-dependent drug delivery systems, that is, the systems in which the drug release is controlled by two factors: pH and time, and pH and microflora of the colon. This Editorial article is not intended to offer a comprehensive review on drug delivery, but shall familiarize the readers with the formulation technologies that have been developed for attaining colon-specific drug delivery.
journal_name
Expert Opin Drug Delivjournal_title
Expert opinion on drug deliveryauthors
Patel MMdoi
10.1517/17425247.2011.597739subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1247-58issue
10eissn
1742-5247issn
1744-7593journal_volume
8pub_type
社论abstract:IMPORTANCE OF THE FIELD:Efficient systemic delivery of low-molecular-mass therapeutics to neuronal tissue remains a central issue not only to drug development but also to the chronic treatment of a range of neurodegenerative disorders. AREAS COVERED IN THIS REVIEW:This review discusses the potential of using RNA inter...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2010.490554
更新日期:2010-07-01 00:00:00
abstract:INTRODUCTION:The identification of more efficient gene delivery vehicles (GDVs) is essential to fulfill the expectations of clinical gene therapy. Bacteriophages, due to their excellent safety profile, extreme stability under a variety of harsh environmental conditions and the capability for being genetically manipulat...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2014.927437
更新日期:2014-10-01 00:00:00
abstract:INTRODUCTION:Considering that the number of patients afflicted by posterior eye diseases is increasing, effective drug delivery is currently in high clinical demand. Topical administration has been identified as the preferred option, while sufferingfrom multiple barriers. The development of nanoparticle-based drug deli...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1080/17425247.2018.1496080
更新日期:2018-07-01 00:00:00
abstract:INTRODUCTION:Gastroretentive floating drug delivery systems have emerged as efficient approaches for enhancing the bioavailability and controlled delivery of various therapeutic agents. Significant advancements exploiting chitosan have been made worldwide, in order to investigate these systems according to patient requ...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2012.673581
更新日期:2012-05-01 00:00:00
abstract:AIM:The mechanical properties and compaction characteristics of different varieties of Assam Bora rice flours (ABRFs) were evaluated and compared with those of official Starch 1500®. METHODS:The material properties and compression characteristics of Assam Bora rice flours were studied by Heckel and Kawakita analysis. ...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章
doi:10.1517/17425247.2013.736963
更新日期:2013-02-01 00:00:00
abstract::Targeting vaccines to the skin epidermis results in the activation of an immune inductive site that is rich in antigen-presenting cells. The superficial location of the skin makes it accessible to vaccine delivery. However, it is difficult to access the epidermis using needle and syringe delivery, and vaccine antigens...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2.2.227
更新日期:2005-03-01 00:00:00
abstract:IMPORTANCE OF THE FIELD:Active targeting of bioactive molecules by physicochemical association with hyaluronic acid (HA) is an attractive approach in current nanomedicine because HA is biocompatible, non-toxic and non-inflammatory. AREAS COVERED IN THIS REVIEW:This review focuses on synthesis, physicochemical characte...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425241003730399
更新日期:2010-06-01 00:00:00
abstract:IMPORTANCE OF THE FIELD:The review presents the design strategy and synthesis of multifunctional dendrimers and hyperbranched polymers with the objective to develop effective drug delivery systems. AREAS COVERED IN THIS REVIEW:Well-characterized, commercially available dendritic polymers were subjected to functionaliz...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2010.534981
更新日期:2010-12-01 00:00:00
abstract::Liver fibrosis and its end stage disease cirrhosis are a major cause of mortality and morbidity around the world. There is no effective pharmaceutical intervention for liver fibrosis at present. Many drugs that show potent antifibrotic activities in vitro often show only minor effects in vivo because of insufficient c...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425240902936834
更新日期:2009-05-01 00:00:00
abstract:INTRODUCTION:Nanocomposite microparticles are intelligent carriers utilised for pulmonary drug delivery. These carriers are composed of drug-encapsulated nanoparticles dispersed in microstructures of polysaccharides. Upon administration, the inhaled microparticles can penetrate and be deposited deeply in the lung due t...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2016.1102224
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Superparamagnetic iron oxide nanoparticle (SPION)-based carrier systems have many advantages over other nanoparticle-based systems. They are biocompatible, biodegradable, facilely tunable and superparamagnetic and thus controllable by an external magnetic field. These attributes enable their broad biomedic...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2013.747507
更新日期:2013-01-01 00:00:00
abstract::The CYPHER (Cordis, Johnson & Johnson) sirolimus-eluting stent and the TAXU (Boston Scientific) paclitaxel-eluting stent have been extensively evaluated and have been proven to be significant novel tools for the treatment of coronary artery disease. Several sirolimus derivatives have already emerged, receiving CE Mark...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.3.6.783
更新日期:2006-11-01 00:00:00
abstract:INTRODUCTION:Development of efficient in vivo delivery systems remains a major challenge en route to clinical application of antisense technology, including RNA-cleaving molecules such as deoxyribozymes (DNAzymes). The mechanisms of oligonucleotide uptake and trafficking are clearly dependent on cell type and the type ...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1080/17425247.2017.1266326
更新日期:2017-09-01 00:00:00
abstract::Objective: Conventional chloramphenicol (CHL) eye drops are widely used anti-infection formulations for acute bacterial conjunctivitis. However, the therapeutic effects are limited by insufficient concentration in the conjunctival sac. Hence, the objective of this study is to formulate and develop novel CHL eye drops ...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章
doi:10.1080/17425247.2019.1609447
更新日期:2019-06-01 00:00:00
abstract::Introduction: Making selective inhibitors of novel Gram-negative targets is not a substantial challenge - getting them into Gram-negative bacteria to reach their lethal target is the bottleneck. Poor permeability of the antibiotic requires high concentration causing off target activity. The lack of simple experimental...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章
doi:10.1080/17425247.2021.1847080
更新日期:2020-11-13 00:00:00
abstract:INTRODUCTION:Macromolecular therapeutics, including enzymes, transcription factors, siRNAs, peptides and large synthetic molecules, can potentially be used to treat human diseases by targeting intracellular molecular pathways and modulating biological responses. However, large macromolecules have no ability to enter ce...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2015.1046431
更新日期:2015-01-01 00:00:00
abstract::Directly delivering liquid using direct current power was a dream for 40 years. Now, the electrokinetic pump can accomplish it. This review reports recent developments in microfabricated electrokinetic pump technologies and their applications, and also discusses the electrophoresis pump and elctroosmotic pump, as well...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.4.2.119
更新日期:2007-03-01 00:00:00
abstract:INTRODUCTION:Harnessing RNA interference as a therapeutic approach has the potential to significantly expand the druggable target space, offering new hope for treatment of diseases that cannot be addressed with existing classes of drugs. A number of siRNA therapeutics have already progressed into preclinical and clinic...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2012.642363
更新日期:2012-02-01 00:00:00
abstract:INTRODUCTION:Management of Osteoarthritis (OA) still is a challenge for clinicians. Taking into account a multidisciplinary approach including pharmacological and non-pharmacological treatments, intra-articular (IA) injection could be considered as an effective local therapy. Areas covered This review provides a new pe...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1080/17425247.2020.1783234
更新日期:2020-09-01 00:00:00
abstract:INTRODUCTION:Topically applied small interfering RNA (siRNA) can be an effective treatment for skin disorders. Using noninvasive strategies can be a safe and effective siRNA-permeation-enhancement approach for facilitating skin delivery. It has been demonstrated that noninvasive approaches for enhancing siRNA transport...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2016.1121988
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Injectable life-saving drugs should not be exposed to temperatures <4°C/39°F or >30°C/86°F. Frequently, weather conditions exceed these temperature thresholds in many countries. Insulin is to be kept at 4-8°C/~ 39-47°F until use and once opened, is supposed to be stable for up to 31 days at room temperature ...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章
doi:10.1080/17425247.2017.1316261
更新日期:2017-06-01 00:00:00
abstract:IMPORTANCE OF THE FIELD:The prediction of the in vivo drug release characteristics of modified release (MR) oral dosage forms by in vitro dissolution tests is a prerequisite for successful product development. AREAS COVERED IN THIS REVIEW:To improve the predictive power of dissolution testing, the authors recently dev...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2010.527943
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:We hypothesized if phagocytosis of liposomes by macrophages could be mitigated through incorporation of a CD47 mimicry peptide (Self peptide: SP) on the surface of liposomes. METHODS:Thin film hydration method followed by extrusion was used to prepare nanoliposomes, and Dox encapsulation in liposomes was do...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章
doi:10.1080/17425247.2020.1772749
更新日期:2020-07-01 00:00:00
abstract::Devices for the aqueous delivery of intranasal corticosteroids to patients with allergic rhinitis have been available since 1984, so there is a need for new devices to be developed to provide ease of use, efficacy and safety. A novel drug delivery system has been developed for fluticasone furoate (FF; GlaxoSmithKline)...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.4.6.689
更新日期:2007-11-01 00:00:00
abstract:INTRODUCTION:Oral delivery of therapeutic peptide hormones offers the promise of greater patient compliance when compared to parenteral administration routes. However, it is a huge challenge in the pharmaceutical field. Due to increasing demand for oral delivery of peptide hormones such as insulin, gonadotropin-releasi...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2016.1142526
更新日期:2016-01-01 00:00:00
abstract::With the advent of new, and often expensive, therapeutics designed for aerosol delivery to the lung, there is a need to improve the targeting and efficiency of their delivery. By controlling breathing patterns associated with inhaled aerosols, it has been shown that deposition in the lung can be both maximised and tar...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章
doi:10.1517/17425247.2.4.763
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:Test the hypothesis that pegylated meglumine antimoniate-containing liposomes (LMA) and their mixture with non-pegylated (conventional) LMA may be more effective than conventional LMA against visceral leishmaniasis (VL), because of wider drug distribution among different mononuclear phagocyte system (MPS) tis...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章
doi:10.1517/17425247.2014.932347
更新日期:2014-10-01 00:00:00
abstract:INTRODUCTION:Overexpression of VEGF has been identified to be associated with many pathologic processes such as tumors and retinopathy. Inhibiting uncontrolled growth of VEGF is a promising strategy to treat these diseases. Currently small molecule inhibitors and monoclonal antibodies are the primary treatment. However...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2014.926886
更新日期:2014-09-01 00:00:00
abstract:INTRODUCTION:The emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) is a major health issue and continues to be a global health concern. Despite significant advancements in treatment modalities, ~1.6 million deaths worldwide occur due to TB infection. This is bec...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1080/17425247.2019.1609937
更新日期:2019-05-01 00:00:00
abstract:INTRODUCTION:The utility of controlled and sustained release of drugs from polymeric systems, both bulk (hydrogels) and colloids (nanoparticles), is a key point that should be addressed. Unfortunately, classic delivery systems are essentially driven by diffusion, which is very quick due to the high concentration gradie...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1080/17425247.2017.1285280
更新日期:2017-11-01 00:00:00