Abstract:
INTRODUCTION:The emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) is a major health issue and continues to be a global health concern. Despite significant advancements in treatment modalities, ~1.6 million deaths worldwide occur due to TB infection. This is because of tuberculosis reservoirs in the alveoli making it a challenge for the formulation scientist to target this. AREAS COVERED:This review recent investigations on the forefront of pulmonary drug delivery for managing MDR-TB and XDR-TB. Novel delivery systems like liposomes, niosomes, employing carbohydrate, and -coated molecules via conjugation to selectively deliver the drugs to the lung TB reservoir via pulmonary administration are discussed. EXPERT OPINION:Poor patient adherence to treatment due to side effects and extended therapeutic regimen leads to drug-resistant TB. Thus, it is essential to design novel strategies this issue by developing new chemical entities and/or new delivery systems for delivery to the lungs, consequently reducing the side effects, the frequency and the duration of treatment. Delivery of drugs to enhance the efficacy of new/existing anti-TB drugs to overcome the resistance and enhance patient compliance is underway.
journal_name
Expert Opin Drug Delivjournal_title
Expert opinion on drug deliveryauthors
Sankhe K,Khan T,Bhavsar C,Momin M,Omri Adoi
10.1080/17425247.2019.1609937subject
Has Abstractpub_date
2019-05-01 00:00:00pages
525-538issue
5eissn
1742-5247issn
1744-7593journal_volume
16pub_type
杂志文章,评审abstract::Beta-adrenoceptor blocking drugs (beta-blockers) are one of the most frequently used class of cardiovascular drugs that are mainly used in conventional dosage forms., which have their own limitations including hepatic first-pass metabolism, high incidence of adverse effects due to variable absorption profiles, higher ...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.3.3.405
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Photodynamic therapy (PDT) is a medical treatment in which a combination of a photosensitising drug and visible light causes destruction of selected cells. Due to the lack of true selectivity of preformed photosensitisers for neoplastic tissue and their high molecular weights, PDT of superficial skin lesions...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.5.7.757
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abstract:INTRODUCTION:Current treatment of malignant tumors relies predominantly on chemotherapy delivering a single antineoplastic drug or a combination of two or more drugs intravenously. Problems with such treatments can include the killing of healthy cells, adverse side effects and chemoresistance. As cancer basically resul...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章
doi:10.1517/17425247.2011.554817
更新日期:2011-03-01 00:00:00
abstract:INTRODUCTION:Currently, hot melt extrusion (HME) is a promising technology in the pharmaceutical industry, as evidenced by its application to manufacture various FDA-approved commercial products in the market. HME is extensively researched for enhancing the solubility and bioavailability of poor water-soluble drugs, ta...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1080/17425247.2019.1609448
更新日期:2019-05-01 00:00:00
abstract:INTRODUCTION:Gemcitabine, an anticancer drug, is a nucleoside analog deoxycytidine antimetabolite, which acts against a wide range of solid tumors. The limitation of gemcitabine is its rapid inactivation by the deoxycytidine deaminase enzyme following its in vivo administration. AREAS COVERED:One of the most promising...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2011.632630
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abstract:BACKGROUND:Inhalation of microparticulate dosage forms can be effectively used in the treatment of respiratory and systemic diseases. OBJECTIVE:Disease states investigated for treatment by inhalation of microparticles were reviewed along with the drugs' pharmacological, pharmacokinetic and physical chemical properties...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.5.3.269
更新日期:2008-03-01 00:00:00
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1080/17425247.2016.1188802
更新日期:2016-10-01 00:00:00
abstract:INTRODUCTION:Pressurized metered dose inhalers (pMDIs) are evolving to be a very effective drug delivery option in patients with airway diseases. They offer comparable lung deposition and reduced oropharyngeal deposition similar with the dry powder inhalers. As recommended by the Global Initiative for Asthma guidelines...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章
doi:10.1517/17425247.2.4.763
更新日期:2005-07-01 00:00:00
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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更新日期:2020-01-01 00:00:00
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2014.866089
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章
doi:10.1517/17425247.2014.932347
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journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1080/17425247.2018.1446937
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journal_title:Expert opinion on drug delivery
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abstract:INTRODUCTION:Harnessing RNA interference as a therapeutic approach has the potential to significantly expand the druggable target space, offering new hope for treatment of diseases that cannot be addressed with existing classes of drugs. A number of siRNA therapeutics have already progressed into preclinical and clinic...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.2012.642363
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abstract:AIM:The mechanical properties and compaction characteristics of different varieties of Assam Bora rice flours (ABRFs) were evaluated and compared with those of official Starch 1500®. METHODS:The material properties and compression characteristics of Assam Bora rice flours were studied by Heckel and Kawakita analysis. ...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章
doi:10.1517/17425247.2013.736963
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