Challenges in the pharmaceutical development of lipid-based short interfering ribonucleic acid therapeutics.

abstract：OBJECTIVE:Test the hypothesis that pegylated meglumine antimoniate-containing liposomes (LMA) and their mixture with non-pegylated (conventional) LMA may be more effective than conventional LMA against visceral leishmaniasis (VL), because of wider drug distribution among different mononuclear phagocyte system (MPS) tis...

journal_title：Expert opinion on drug delivery

authors： Azevedo EG,Ribeiro RR,da Silva SM,Ferreira CS,de Souza LE,Ferreira AA,de Oliveira E Castro RA,Demicheli C,Rezende SA,Frézard F

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:Dextran is a family of natural polysaccharides that is widely under investigation for use as polymeric carriers in novel drug delivery systems. The optimal drug delivery (and consequently maximum therapeutic effect) will be accomplished when carrier systems are used mainly for drugs with antitumoral activi...

journal_title：Expert opinion on drug delivery

authors： Varshosaz J

更新日期：2012-05-01 00:00:00

abstract：INTRODUCTION:The utility of controlled and sustained release of drugs from polymeric systems, both bulk (hydrogels) and colloids (nanoparticles), is a key point that should be addressed. Unfortunately, classic delivery systems are essentially driven by diffusion, which is very quick due to the high concentration gradie...

journal_title：Expert opinion on drug delivery

authors： Mauri E,Papa S,Masi M,Veglianese P,Rossi F

更新日期：2017-11-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Vascular delivery of several classes of therapeutic agents may benefit from carriage by red blood cells (RBC), for example, drugs that require delivery into phagocytic cells and those that must act within the vascular lumen. The fact that several protocols of infusion of RBC-encapsulated drugs a...

journal_title：Expert opinion on drug delivery

authors： Muzykantov VR

更新日期：2010-04-01 00:00:00

abstract：:Introduction: Poloxamer based in situ gelling systems offer numerous advantages in drug delivery; however, their application as prolonged-release delivery platforms is limited mainly due to their weak mechanical properties and the interconnected aqueous network causing fast gel erosion and drug diffusion.Area covered:...

journal_title：Expert opinion on drug delivery

authors： Abdeltawab H,Svirskis D,Sharma M

更新日期：2020-04-01 00:00:00

abstract：INTRODUCTION:Carbohydrates are key participants in many biological processes including reproduction, inflammation, signal transmission and infection. Their biocompatibility and ability to be recognized by cell-surface receptors illustrate their potential therapeutic applications. αYet, they are not ideal candidates bec...

journal_title：Expert opinion on drug delivery

authors： Sunasee R,Adokoh CK,Darkwa J,Narain R

更新日期：2014-06-01 00:00:00

abstract：INTRODUCTION:Use of pre-filled syringes as both a packaging and delivery system for pharmaceutical drug products is accelerating. Pre-filled syringes must meet the quality and suitability for use requirements for both systems, including compatibility with the drug product. Relevant incompatibilities between pre-filled ...

journal_title：Expert opinion on drug delivery

authors： Jenke DR

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:Ultrasound enhancement of thrombolysis (sonothrombolysis) is further potentiated by administration of acoustically active microbubbles, which may be developed into powerful adjuvant therapies for thrombolytic treatment of occlusive conditions such as ischaemic stroke. AREAS COVERED:The role of microbubble...

journal_title：Expert opinion on drug delivery

authors： de Saint Victor M,Crake C,Coussios CC,Stride E

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:The advent of therapeutic proteins highlights the need for delivery systems that protect and extend the duration of its action. Ranibizumab-VEGF is one such drug used for treating wet AMD. This paper describes a facile method to sustain bioactive ranibizumab release from PLGA-based particles. METHODS:Two em...

journal_title：Expert opinion on drug delivery

authors： Chua HY,Lui YS,Bhuthalingam R,Agrawal R,Wong T,Preiser PR,Venkatraman S

更新日期：2018-12-01 00:00:00

abstract：INTRODUCTION:A nanosuspension or nanocrystal suspension is a versatile formulation combining conventional and innovative features. It comprises 100% pure drug nanoparticles with sizes in the nano-scale range, generally stabilized by surfactants or polymers. Nanosuspensions are usually obtained in liquid media with bott...

journal_title：Expert opinion on drug delivery

authors： Leone F,Cavalli R

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Transdermal drug delivery has several known advantages over the oral route and hypodermic injections. The number of drugs that can be taken up transdermally is, however, limited owing to the innate barrier function of the skin. New transdermal drug candidates need to be tested extensively before being used...

journal_title：Expert opinion on drug delivery

authors： Van Gele M,Geusens B,Brochez L,Speeckaert R,Lambert J

更新日期：2011-06-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Recently, there has been substantial progress in the development of integrin targeted pharmaceuticals and drug delivery systems. Integrin is an important member in the cell adhesion molecule family, which is involved in regulation of complex biological conditions, from keeping normal physiologic...

journal_title：Expert opinion on drug delivery

authors： Wang Z,Chui WK,Ho PC

更新日期：2010-02-01 00:00:00

abstract：INTRODUCTION:Gemcitabine, an anticancer drug, is a nucleoside analog deoxycytidine antimetabolite, which acts against a wide range of solid tumors. The limitation of gemcitabine is its rapid inactivation by the deoxycytidine deaminase enzyme following its in vivo administration. AREAS COVERED:One of the most promising...

journal_title：Expert opinion on drug delivery

authors： Celia C,Cosco D,Paolino D,Fresta M

更新日期：2011-12-01 00:00:00

abstract：:In the last decade, interest in physical organogels has grown rapidly with the discovery and synthesis of a very large number of diverse molecules, which can gel organic solvents at low concentrations. The gelator molecules immobilise large volumes of liquid following their self-assembly into a variety of aggregates s...

journal_title：Expert opinion on drug delivery

authors： Murdan S

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Injectable life-saving drugs should not be exposed to temperatures <4°C/39°F or >30°C/86°F. Frequently, weather conditions exceed these temperature thresholds in many countries. Insulin is to be kept at 4-8°C/~ 39-47°F until use and once opened, is supposed to be stable for up to 31 days at room temperature ...

journal_title：Expert opinion on drug delivery

authors： Pfützner A,Pesach G,Nagar R

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVES:Methotrexate (MTX) is a chemotherapeutic and anti-inflammatory drug that may cause systemic adverse effects. This study investigated kinetics and biodistribution of MTX delivered topically by ablative fractional laser (AFXL). METHODS:In vitro passive diffusion of 10 mg/ml MTX (1 w/v%) was measured from 0.25...

journal_title：Expert opinion on drug delivery

authors： Taudorf EH,Lerche CM,Vissing AC,Philipsen PA,Hannibal J,D'Alvise J,Hansen SH,Janfelt C,Paasch U,Anderson RR,Haedersdal M

更新日期：2015-07-01 00:00:00

abstract：INTRODUCTION:Interest in mesoporous silica nanoparticles for drug delivery has resulted in a good understanding of the impact of size and surface chemistry of these nanoparticles on their performance as drug carriers. Shape has emerged as an additional factor that can have a significant effect on delivery efficacy. Rod...

journal_title：Expert opinion on drug delivery

authors： Cong VT,Gaus K,Tilley RD,Gooding JJ

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Targeted delivery of antithrombotic (thrombolytic) drugs is expected to increase their efficacy and decrease side effects, especially in the case of thrombolytic enzymes. Liposomes, phospholipid nanosized bubbles with a bilayered membrane structure, have drawn a lot of interest as pharmaceutical carriers for...

journal_title：Expert opinion on drug delivery

authors： Elbayoumi TA,Torchilin VP

更新日期：2008-11-01 00:00:00

abstract：:Introduction: Thymoquinone (TQ), 2-isopropyl-5-methylbenzo-1, 4-quinone, the main active constituent of Nigella sativa (NS) plant, has been proven to be of great therapeutic aid in various in vitro and in vivo conditions. Despite the promising therapeutic activities of TQ, this molecule is not yet in the clinical tria...

journal_title：Expert opinion on drug delivery

authors： Rathore C,Rathbone MJ,Chellappan DK,Tambuwala MM,Pinto TJA,Dureja H,Hemrajani C,Gupta G,Dua K,Negi P

更新日期：2020-04-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Since the 1950s, ultrasonic nebulizers have played an important role in pulmonary drug delivery. As the process in which aerosol droplets are generated is independent and does not require breath-actuation, ultrasonic nebulizers, in principle, offer the potential for instantaneously fine-tuning t...

journal_title：Expert opinion on drug delivery

authors： Yeo LY,Friend JR,McIntosh MP,Meeusen EN,Morton DA

更新日期：2010-06-01 00:00:00

abstract：INTRODUCTION:Delivery of macromolecular drugs is an important field in medical research. However, macromolecules are usually unable to cross the cell membrane without the assistance of a delivery system. Cell penetrating peptides (CPPs) are unique tools to gain access to the cell interior and deliver a bioactive cargo ...

journal_title：Expert opinion on drug delivery

authors： Kurrikoff K,Gestin M,Langel Ü

更新日期：2016-01-01 00:00:00

abstract：:Liver fibrosis and its end stage disease cirrhosis are a major cause of mortality and morbidity around the world. There is no effective pharmaceutical intervention for liver fibrosis at present. Many drugs that show potent antifibrotic activities in vitro often show only minor effects in vivo because of insufficient c...

journal_title：Expert opinion on drug delivery

authors： Li F,Wang JY

更新日期：2009-05-01 00:00:00

abstract：:Nitric oxide (NO), the 1992 'Molecule of the Year', is the focus of immense medical and scientific exploration. Interest in NO has grown exponentially since the initial and relatively recent discovery that NO is the long sought after endothelial relaxing factor. There is intense research that is continuing to expose t...

journal_title：Expert opinion on drug delivery

authors： Friedman A,Friedman J

更新日期：2009-10-01 00:00:00

abstract：INTRODUCTION:Recent developments in ultrasound imaging and ultrasound contrast agents (UCAs) improved diagnostic confidence in echography and set into motion their combined use as a tool for drug delivery and therapeutic monitoring. Non-invasive, precise and targeted delivery of drug molecules to pathological tissues b...

journal_title：Expert opinion on drug delivery

authors： Sennoga CA,Kanbar E,Auboire L,Dujardin PA,Fouan D,Escoffre JM,Bouakaz A

更新日期：2017-09-01 00:00:00

abstract：INTRODUCTION:In the therapy of clinical diseases such as cancer, it is important to deliver drugs directly to tumor sites in order to maximize local drug concentration and reduce side effects. This objective may be realized by using 'smart' nanoparticles (NPs) as drug delivery systems, because they enable dramatic conf...

journal_title：Expert opinion on drug delivery

authors： Fang Z,Wan LY,Chu LY,Zhang YQ,Wu JF

更新日期：2015-01-01 00:00:00

abstract：:Due to the poor solvent properties of hydrofluoroalkanes, suspension is often the only formulation option for respiratory drug delivery. Research in this area has focussed mainly on two main themes over the past 5 years: new design of stabilisers and particle engineering. Among the most important advances, the introdu...

journal_title：Expert opinion on drug delivery

authors： Rogueda P

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Alendronate sodium (ALS) is the most common drug used for the treatment of osteoporosis. The challenges facing ALS use include: very poor oral bioavailability (0.6%), esophageal ulcers, and complicated instructions for its use. The objective of this research is to utilize nanotechnology to for...

journal_title：Expert opinion on drug delivery

authors： Hosny KM,Ahmed OA,Al-Abdali RT

更新日期：2013-06-01 00:00:00

abstract：INTRODUCTION:Cancer is a leading cause of death worldwide and efficient new strategies are urgently needed to combat its high mortality and morbidity statistics. Fortunately, over the years, nanotechnology has evolved as a frontrunner in the areas of imaging, diagnostics and therapy, giving the possibility of monitorin...

journal_title：Expert opinion on drug delivery

authors： Luque-Michel E,Imbuluzqueta E,Sebastián V,Blanco-Prieto MJ

更新日期：2017-01-01 00:00:00

abstract：:Devices for the aqueous delivery of intranasal corticosteroids to patients with allergic rhinitis have been available since 1984, so there is a need for new devices to be developed to provide ease of use, efficacy and safety. A novel drug delivery system has been developed for fluticasone furoate (FF; GlaxoSmithKline)...

journal_title：Expert opinion on drug delivery

authors： Berger WE,Godfrey JW,Slater AL

更新日期：2007-11-01 00:00:00

abstract：INTRODUCTION:Glioblastoma is a type of brain cancer arises from glial cells. Glioblastoma multiforme (GBM), a subtype of glioblastoma, is the most common and most aggressive primary brain tumor. Currently, GBM therapy includes surgery and post-operative high-doses of radiation and chemotherapy. This therapeutic strateg...

journal_title：Expert opinion on drug delivery

authors： Gutkin A,Cohen ZR,Peer D

更新日期：2016-11-01 00:00:00