Use of nanoscale delivery systems to maintain synergistic drug ratios in vivo.

abstract：:Background: Anti-tumor necrosis factor (anti-TNF) adherence is suboptimal. ava®, a reusable electromechanical self-injection device (e-Device) developed for certolizumab pegol (CZP) administration, aims to overcome some barriers to increase adherence. This study evaluates patient experience of the e-Device and its tra...

journal_title：Expert opinion on drug delivery

authors： Pouls BPH,Kristensen LE,Petersson M,van den Bemt BJF,Ballerini L,Bruggraber R,Karlen H,Mountian I,van Bracht E,Wiegratz S,Jørgensen TS

更新日期：2020-05-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Cancer is the most formidable human disease. Owing to the heterogeneity of cancer, a single-treatment modality is insufficient for the complete elimination of cancer cells. Therapeutic strategies from various aspects are needed for cancer therapy. These therapeutic agents should be carefully sel...

journal_title：Expert opinion on drug delivery

authors： Kaneda Y

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:The lung comprises an interesting route of administration not only for topical drugs but also for systemically acting drugs. Over the last years, several models have been developed in order to study the efficacy and safety of pulmonary drug delivery. OBJECTIVE:This review describes relevant drug delivery mo...

journal_title：Expert opinion on drug delivery

authors： Fernandes CA,Vanbever R

更新日期：2009-11-01 00:00:00

abstract：INTRODUCTION:The identification of more efficient gene delivery vehicles (GDVs) is essential to fulfill the expectations of clinical gene therapy. Bacteriophages, due to their excellent safety profile, extreme stability under a variety of harsh environmental conditions and the capability for being genetically manipulat...

journal_title：Expert opinion on drug delivery

authors： Bakhshinejad B,Sadeghizadeh M

更新日期：2014-10-01 00:00:00

abstract：:The use of gated mesoporous silica solids as suitable systems for controlled-release protocols is reviewed. These materials are based on mesoporous silica supports that can be prepared with tailor-made pores of around 2 - 10 nm and that show a very large specific surface area (up to 1200 m(2)/g), thus having a large l...

journal_title：Expert opinion on drug delivery

authors： Aznar E,Martínez-Máñez R,Sancenón F

更新日期：2009-06-01 00:00:00

abstract：INTRODUCTION:Pressurized metered dose inhalers (pMDIs) are evolving to be a very effective drug delivery option in patients with airway diseases. They offer comparable lung deposition and reduced oropharyngeal deposition similar with the dry powder inhalers. As recommended by the Global Initiative for Asthma guidelines...

journal_title：Expert opinion on drug delivery

authors： Mehta N,Aggarwal B,Gogtay J,Abdool-Gaffar S

更新日期：2015-06-01 00:00:00

abstract：INTRODUCTION:Superparamagnetic iron oxide nanoparticle (SPION)-based carrier systems have many advantages over other nanoparticle-based systems. They are biocompatible, biodegradable, facilely tunable and superparamagnetic and thus controllable by an external magnetic field. These attributes enable their broad biomedic...

journal_title：Expert opinion on drug delivery

authors： Mok H,Zhang M

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Polymer-drug conjugates are an important part of polymer therapeutics. Recently, they have been used as an appealing platform for drug delivery. As a delivery vector, the route of administration performs a serious impact on the accessibility of drug molecules to their respective target site and therapeutic...

journal_title：Expert opinion on drug delivery

authors： Pang X,Yang X,Zhai G

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:The present work aims to formulate nanostructured lipid carriers (NLCs) exhibiting high skin deposition and high inherent antioxidant potential to repurpose the use of melatonin hormone and some antioxidant oils in the treatment of androgenic alopecia (AGA). RESEARCH DESIGN AND METHODS:NLCs were characteriz...

journal_title：Expert opinion on drug delivery

authors： Hatem S,Nasr M,Moftah NH,Ragai MH,Geneidi AS,Elkheshen SA

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:Current treatment of malignant tumors relies predominantly on chemotherapy delivering a single antineoplastic drug or a combination of two or more drugs intravenously. Problems with such treatments can include the killing of healthy cells, adverse side effects and chemoresistance. As cancer basically resul...

journal_title：Expert opinion on drug delivery

authors： Chowdhury EH

更新日期：2011-03-01 00:00:00

abstract：INTRODUCTION:Overactive bladder affects a significant portion of the population and results in prescribing of numerous medications for its treatment. Traditional drug delivery systems used in therapy are associated with multiple commonly reported side effects. Adherence rates with use of these medications are low. It i...

journal_title：Expert opinion on drug delivery

authors： Scott K,Dmochowski RR,Padmanabhan P

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Efficient and minimally invasive vector systems appear to be the most appropriate for both gene therapy and drug delivery. Numerous viral and non-viral vectors have been developed. Each vector has its own advantages and limitations. OBJECTIVE:New vectors have been required for overcoming the limitations of ...

journal_title：Expert opinion on drug delivery

authors： Kaneda Y

更新日期：2008-02-01 00:00:00

abstract：:Many agents used to treat cancer are toxic to normal tissues. Thus, treatments delivering drug specifically to tumour, while minimising exposure to normal tissue, may be advantageous over non-targeted treatments. The exquisite specificity of the immune system has been used successfully to help develop targeted antican...

journal_title：Expert opinion on drug delivery

authors： Brumlik MJ,Daniel BJ,Waehler R,Curiel DT,Giles FJ,Curiel TJ

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:The renaissance in drug delivery research during the past decade led to several new approaches toward vaccine development. Transdermal immunization (TI) is a promising modality with both practical and immunological merits. Compared with conventional routes of administration, this needle-free delivery appro...

journal_title：Expert opinion on drug delivery

authors： Mishra DK,Dhote V,Mishra PK

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:The present work focuses on the development of ultra-small solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) encapsulating cyclosporine and calcipotriol, further incorporated into gel, increasing their penetration through the skin. RESEARCH DESIGN AND METHODS:Developed SLN and NLC were...

journal_title：Expert opinion on drug delivery

authors： Arora R,Katiyar SS,Kushwah V,Jain S

更新日期：2017-02-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Vascular delivery of several classes of therapeutic agents may benefit from carriage by red blood cells (RBC), for example, drugs that require delivery into phagocytic cells and those that must act within the vascular lumen. The fact that several protocols of infusion of RBC-encapsulated drugs a...

journal_title：Expert opinion on drug delivery

authors： Muzykantov VR

更新日期：2010-04-01 00:00:00

abstract：INTRODUCTION:Recent advances in pharmacological therapies to treat ocular diseases such as glaucoma, age-related macular degeneration, diabetic macular edema and retinal vascular occlusions have greatly improved the prognosis for these diseases. Due to these advances in pharmacological therapy, there is a great deal of...

journal_title：Expert opinion on drug delivery

authors： Kang-Mieler JJ,Osswald CR,Mieler WF

更新日期：2014-10-01 00:00:00

abstract：:With the advent of new, and often expensive, therapeutics designed for aerosol delivery to the lung, there is a need to improve the targeting and efficiency of their delivery. By controlling breathing patterns associated with inhaled aerosols, it has been shown that deposition in the lung can be both maximised and tar...

journal_title：Expert opinion on drug delivery

authors： Bennett WD

更新日期：2005-07-01 00:00:00

abstract：:Introduction: Peritoneal metastases of cancer remain a major cause of an adverse outcome and death following surgical treatment of malignancies that occur within the abdomen and pelvis. The administration of a chemotherapy solution directly into the peritoneal space has been used to improve the survival in this group ...

journal_title：Expert opinion on drug delivery

authors： Sugarbaker PH

更新日期：2019-12-01 00:00:00

abstract：INTRODUCTION:Radioimmunotherapy (RIT) with monoclonal antibodies and their fragments labelled with radionuclides emitting α -particles, β-particles or Auger electrons have been used for many years in the development of anticancer strategies. While RIT has resulted in approved radiopharmaceuticals for the treatment of h...

journal_title：Expert opinion on drug delivery

authors： Martins CD,Kramer-Marek G,Oyen WJG

更新日期：2018-02-01 00:00:00

abstract：:Cancer is the second leading cause of death in the US. Currently, protocols for cancer treatment include surgery to remove diseased and suspect tissues, focused radiation, systemic chemotherapy, immunotherapy and their combinations. With conventional chemotherapy, it is almost impossible to deliver anticancer drugs sp...

journal_title：Expert opinion on drug delivery

authors： Xie Y,Bagby TR,Cohen MS,Forrest ML

更新日期：2009-08-01 00:00:00

abstract：INTRODUCTION:Macromolecular therapeutics, including enzymes, transcription factors, siRNAs, peptides and large synthetic molecules, can potentially be used to treat human diseases by targeting intracellular molecular pathways and modulating biological responses. However, large macromolecules have no ability to enter ce...

journal_title：Expert opinion on drug delivery

authors： Lönn P,Dowdy SF

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Research into oral delivery of biologics has a long and rich history but has not produced technologies used in the clinic. The area has evolved in terms of strategies to promote oral biologics delivery from early chemical absorption enhancers to nanomedicine to devices. Continued activity in this area is j...

journal_title：Expert opinion on drug delivery

authors： Vllasaliu D,Thanou M,Stolnik S,Fowler R

更新日期：2018-08-01 00:00:00

abstract：:This review article provides an assessment of advantages/limitations of the use of current in vitro release models to predict in vivo performance of parenteral sustained release products (injectable depots). As highlighted, key characteristics influencing the in vivo drug fate may vary with the route of administration...

journal_title：Expert opinion on drug delivery

authors： Larsen C,Larsen SW,Jensen H,Yaghmur A,Ostergaard J

更新日期：2009-12-01 00:00:00

abstract：INTRODUCTION:Sixty years since its introduction, 5-FU still forms the core of chemotherapy regimens for many types of malignancies. 5-FU is a time-dependent drug but is rapidly degraded in plasma by dihydropyrimidine dehydrogenase (DPD). Although originally developed in an intravenous form, 5-FU oral prodrugs were deve...

journal_title：Expert opinion on drug delivery

authors： Miura K,Shima H,Takebe N,Rhie J,Satoh K,Kakugawa Y,Satoh M,Kinouchi M,Yamamoto K,Hasegawa Y,Kawai M,Kanazawa K,Fujiya T,Unno M,Katakura R

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:Nanocomposite microparticles are intelligent carriers utilised for pulmonary drug delivery. These carriers are composed of drug-encapsulated nanoparticles dispersed in microstructures of polysaccharides. Upon administration, the inhaled microparticles can penetrate and be deposited deeply in the lung due t...

journal_title：Expert opinion on drug delivery

authors： Elsayed I,AbouGhaly MH

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:Methotrexate (MTX) is a chemotherapeutic and anti-inflammatory drug that may cause systemic adverse effects. This study investigated kinetics and biodistribution of MTX delivered topically by ablative fractional laser (AFXL). METHODS:In vitro passive diffusion of 10 mg/ml MTX (1 w/v%) was measured from 0.25...

journal_title：Expert opinion on drug delivery

authors： Taudorf EH,Lerche CM,Vissing AC,Philipsen PA,Hannibal J,D'Alvise J,Hansen SH,Janfelt C,Paasch U,Anderson RR,Haedersdal M

更新日期：2015-07-01 00:00:00

abstract：INTRODUCTION:Dextran is a family of natural polysaccharides that is widely under investigation for use as polymeric carriers in novel drug delivery systems. The optimal drug delivery (and consequently maximum therapeutic effect) will be accomplished when carrier systems are used mainly for drugs with antitumoral activi...

journal_title：Expert opinion on drug delivery

authors： Varshosaz J

更新日期：2012-05-01 00:00:00

abstract：INTRODUCTION:Harnessing RNA interference as a therapeutic approach has the potential to significantly expand the druggable target space, offering new hope for treatment of diseases that cannot be addressed with existing classes of drugs. A number of siRNA therapeutics have already progressed into preclinical and clinic...

journal_title：Expert opinion on drug delivery

authors： Gindy ME,Leone AM,Cunningham JJ

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Therapeutic peptides have great potential as anticancer agents owing to their ease of rational design and target specificity. However, their utility in vivo is limited by low stability and poor tumor penetration. OBJECTIVE:The authors review the development of peptide inhibitors with potential for cancer th...

journal_title：Expert opinion on drug delivery

authors： Bidwell GL 3rd,Raucher D

更新日期：2009-10-01 00:00:00