Therapeutic peptides for cancer therapy. Part I - peptide inhibitors of signal transduction cascades.

abstract：INTRODUCTION:The work presents the development of acellular scaffolds extemporaneously embedded with platelet lysate (PL), as an innovative approach in the field of tissue regeneration/reparation. PL embedded scaffolds should have a tridimensional architecture to support cell migration and growth, in order to restore s...

journal_title：Expert opinion on drug delivery

authors： Sandri G,Bonferoni MC,Rossi S,Ferrari F,Mori M,Cervio M,Riva F,Liakos I,Athanassiou A,Saporito F,Marini L,Caramella C

更新日期：2015-04-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Recently, there has been substantial progress in the development of integrin targeted pharmaceuticals and drug delivery systems. Integrin is an important member in the cell adhesion molecule family, which is involved in regulation of complex biological conditions, from keeping normal physiologic...

journal_title：Expert opinion on drug delivery

authors： Wang Z,Chui WK,Ho PC

更新日期：2010-02-01 00:00:00

abstract：INTRODUCTION:Many new drug substances have low aqueous solubility which can cause poor bioavailability after oral administration. The application of solid dispersions is a useful method to increase the dissolution rate of these drugs and thereby improve their bioavailability. So far, several methods have been developed...

journal_title：Expert opinion on drug delivery

authors： Srinarong P,de Waard H,Frijlink HW,Hinrichs WL

更新日期：2011-09-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Active targeting of bioactive molecules by physicochemical association with hyaluronic acid (HA) is an attractive approach in current nanomedicine because HA is biocompatible, non-toxic and non-inflammatory. AREAS COVERED IN THIS REVIEW:This review focuses on synthesis, physicochemical characte...

journal_title：Expert opinion on drug delivery

authors： Ossipov DA

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:The present work focuses on the development of ultra-small solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) encapsulating cyclosporine and calcipotriol, further incorporated into gel, increasing their penetration through the skin. RESEARCH DESIGN AND METHODS:Developed SLN and NLC were...

journal_title：Expert opinion on drug delivery

authors： Arora R,Katiyar SS,Kushwah V,Jain S

更新日期：2017-02-01 00:00:00

abstract：INTRODUCTION:Pressurized metered dose inhalers (pMDIs) are evolving to be a very effective drug delivery option in patients with airway diseases. They offer comparable lung deposition and reduced oropharyngeal deposition similar with the dry powder inhalers. As recommended by the Global Initiative for Asthma guidelines...

journal_title：Expert opinion on drug delivery

authors： Mehta N,Aggarwal B,Gogtay J,Abdool-Gaffar S

更新日期：2015-06-01 00:00:00

abstract：:dl-Methylphenidate (MPH) remains the most widely used pharmacological agent in the treatment of attention-deficit/hyperactivity disorder (ADHD). The predominantly dopaminergic mechanism of the psychostimulant actions has become more clearly defined. Neuroimaging and genetic studies are revealing the underlying neuropa...

journal_title：Expert opinion on drug delivery

authors： Patrick KS,González MA,Straughn AB,Markowitz JS

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Reversible Addition Fragmentation Chain Transfer (RAFT) polymerisation is now an established tool for polymer chemists to create various polymer architectures with precise control over the molecular weight, and to install a variety of different moieties onto the polymer chain ends. Recently, there seems to...

journal_title：Expert opinion on drug delivery

authors： Gregory A,Stenzel MH

更新日期：2011-02-01 00:00:00

abstract：INTRODUCTION:Rapid clearance of drugs from the body results in short therapeutic half-life and is an integral property of many protein and peptide-based drugs. To maintain the desired therapeutic effect patients are required to administer higher doses more frequently, which is inconvenient and risks undesirable side ef...

journal_title：Expert opinion on drug delivery

authors： Sleep D

更新日期：2015-05-01 00:00:00

abstract：:Introduction: Incorrect inhaler technique is one reason why the efficacies of inhaled asthma treatments in clinical trials and effectiveness in the real world differ. Inhaler technique is critical for drug delivery to the lungs; incorrect technique negatively impacts asthma control and long-term outcomes. Breath-trigg...

journal_title：Expert opinion on drug delivery

authors： Usmani O,Roche N,Marshall J,Danagher H,Price D

更新日期：2019-12-01 00:00:00

abstract：INTRODUCTION:Respiratory infections and diseases are accompanied by or exhibit inflammation. Recent advances in nanoparticle engineering technology, together with the increased knowledge of inflammatory pathophysiology, have ignited interest in the pulmonary delivery of anti-inflammatory agents (AIAs) to achieve local ...

journal_title：Expert opinion on drug delivery

authors： Ali ME,McConville JT,Lamprecht A

更新日期：2015-06-01 00:00:00

abstract：:Devices for the aqueous delivery of intranasal corticosteroids to patients with allergic rhinitis have been available since 1984, so there is a need for new devices to be developed to provide ease of use, efficacy and safety. A novel drug delivery system has been developed for fluticasone furoate (FF; GlaxoSmithKline)...

journal_title：Expert opinion on drug delivery

authors： Berger WE,Godfrey JW,Slater AL

更新日期：2007-11-01 00:00:00

abstract：INTRODUCTION:Amphiphilic block copolymers are recognized components of parenteral drug nanocarriers. However, their performance in oral administration has barely been evaluated to any great extent. AREAS COVERED:This review provides an overview of the methods used to prepare drug-loaded polymeric micelles and to evalu...

journal_title：Expert opinion on drug delivery

authors： Simões SM,Figueiras AR,Veiga F,Concheiro A,Alvarez-Lorenzo C

更新日期：2015-02-01 00:00:00

abstract：:The introduction of insulin pens has helped improve adherence in Type 1 or 2 diabetes, and reduce inaccurate dosing, fear of injection, and social embarrassment associated with vial and syringe. This report presents the published evidence base for the accuracy, patient preference and economic evaluation of one prefill...

journal_title：Expert opinion on drug delivery

authors： Pfützner A,Asakura T,Sommavilla B,Lee W

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Efficient and minimally invasive vector systems appear to be the most appropriate for both gene therapy and drug delivery. Numerous viral and non-viral vectors have been developed. Each vector has its own advantages and limitations. OBJECTIVE:New vectors have been required for overcoming the limitations of ...

journal_title：Expert opinion on drug delivery

authors： Kaneda Y

更新日期：2008-02-01 00:00:00

abstract：INTRODUCTION:Most vaccines are administered by intramuscular injection using a hypodermic needle and syringe. Some limitations of this procedure include reluctance to be immunized because of fear of needlesticks, and concerns associated with the safe disposal of needles after their use. Skin delivery is an alternate ro...

journal_title：Expert opinion on drug delivery

authors： Gill HS,Kang SM,Quan FS,Compans RW

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to improve the drug loading (DL) and stability of clarithromycin (CLA)-loaded liposomes, and reduce the irritation caused by intravenous administration of CLA. METHODS:A CLA-cholesteryl hemisuccinate (CHEMS) ion pair (CIP) was prepared by the solvent evaporation method and confirmed...

journal_title：Expert opinion on drug delivery

authors： Geng S,Liu X,Xu H,Cai C,Zhang Y,Yao Q,Xu H,Gou J,Yin T,Xiao W,Tang X

更新日期：2016-01-01 00:00:00

abstract：:Background: Anti-tumor necrosis factor (anti-TNF) adherence is suboptimal. ava®, a reusable electromechanical self-injection device (e-Device) developed for certolizumab pegol (CZP) administration, aims to overcome some barriers to increase adherence. This study evaluates patient experience of the e-Device and its tra...

journal_title：Expert opinion on drug delivery

authors： Pouls BPH,Kristensen LE,Petersson M,van den Bemt BJF,Ballerini L,Bruggraber R,Karlen H,Mountian I,van Bracht E,Wiegratz S,Jørgensen TS

更新日期：2020-05-01 00:00:00

abstract：INTRODUCTION:Topically applied small interfering RNA (siRNA) can be an effective treatment for skin disorders. Using noninvasive strategies can be a safe and effective siRNA-permeation-enhancement approach for facilitating skin delivery. It has been demonstrated that noninvasive approaches for enhancing siRNA transport...

journal_title：Expert opinion on drug delivery

authors： Aljuffali IA,Lin YK,Fang JY

更新日期：2016-01-01 00:00:00

abstract：:Skin diseases are prevalent and can significantly affect quality of life. Empirical mathematical models retrospectively analyse data to predict skin permeation from the physico-chemical properties of drugs. Quantitative structure permeability relationships are discussed, along with alternatives to linear modelling. Me...

journal_title：Expert opinion on drug delivery

authors： Russell LM,Guy RH

更新日期：2009-04-01 00:00:00

abstract：:Introduction: Sativex® spray is clinically utilized to deliver delta9-tetrahydrocannabinol and cannabidiol to oral mucosa for systemic absorption. We challenge the consensus that the mechanism of absorption following the oro-mucosal application occurs via the buccal tissue. Areas covered: Correctness of the consensus ...

journal_title：Expert opinion on drug delivery

authors： Itin C,Domb AJ,Hoffman A

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVES:To develop orodispersible films (ODF) based on hydrophobic polymers with higher stability to ordinary environmental humidity conditions without compromising their fast disintegration time. METHODS:A quality by design approach was applied to screen three different formulations each one based on a different h...

journal_title：Expert opinion on drug delivery

authors： Borges AF,Silva BM,Silva C,Coelho JF,Simões S

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:Dextran is a family of natural polysaccharides that is widely under investigation for use as polymeric carriers in novel drug delivery systems. The optimal drug delivery (and consequently maximum therapeutic effect) will be accomplished when carrier systems are used mainly for drugs with antitumoral activi...

journal_title：Expert opinion on drug delivery

authors： Varshosaz J

更新日期：2012-05-01 00:00:00

abstract：INTRODUCTION:Glioblastoma is a type of brain cancer arises from glial cells. Glioblastoma multiforme (GBM), a subtype of glioblastoma, is the most common and most aggressive primary brain tumor. Currently, GBM therapy includes surgery and post-operative high-doses of radiation and chemotherapy. This therapeutic strateg...

journal_title：Expert opinion on drug delivery

authors： Gutkin A,Cohen ZR,Peer D

更新日期：2016-11-01 00:00:00

abstract：INTRODUCTION:Delivery of macromolecular drugs is an important field in medical research. However, macromolecules are usually unable to cross the cell membrane without the assistance of a delivery system. Cell penetrating peptides (CPPs) are unique tools to gain access to the cell interior and deliver a bioactive cargo ...

journal_title：Expert opinion on drug delivery

authors： Kurrikoff K,Gestin M,Langel Ü

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:The utility of controlled and sustained release of drugs from polymeric systems, both bulk (hydrogels) and colloids (nanoparticles), is a key point that should be addressed. Unfortunately, classic delivery systems are essentially driven by diffusion, which is very quick due to the high concentration gradie...

journal_title：Expert opinion on drug delivery

authors： Mauri E,Papa S,Masi M,Veglianese P,Rossi F

更新日期：2017-11-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Visceral leishmaniasis (VL) is the most overwhelming type of leishmaniasis associated with the poverty of developing countries and usually mortal if untreated. Most of the conventionally used dosage forms offer us the shortcomings of toxic side effects and emergence of drug resistance. Several e...

journal_title：Expert opinion on drug delivery

authors： Gupta S,Pal A,Vyas SP

更新日期：2010-03-01 00:00:00

abstract：INTRODUCTION:Superparamagnetic iron oxide nanoparticle (SPION)-based carrier systems have many advantages over other nanoparticle-based systems. They are biocompatible, biodegradable, facilely tunable and superparamagnetic and thus controllable by an external magnetic field. These attributes enable their broad biomedic...

journal_title：Expert opinion on drug delivery

authors： Mok H,Zhang M

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:The Aluetta™ reusable pen device and instructions for use (IFU) for growth hormone (r-hGH; Saizen®, Merck KGaA, Darmstadt, Germany) administration were tested for Human-Factors Usability, to ensure it could be used safely and effectively by the intended users in the intended use environment. RESEARCH DESIGN ...

journal_title：Expert opinion on drug delivery

authors： Cachemaille A,Warren SE,Moss S

更新日期：2020-07-01 00:00:00

abstract：INTRODUCTION:Sixty years since its introduction, 5-FU still forms the core of chemotherapy regimens for many types of malignancies. 5-FU is a time-dependent drug but is rapidly degraded in plasma by dihydropyrimidine dehydrogenase (DPD). Although originally developed in an intravenous form, 5-FU oral prodrugs were deve...

journal_title：Expert opinion on drug delivery

authors： Miura K,Shima H,Takebe N,Rhie J,Satoh K,Kakugawa Y,Satoh M,Kinouchi M,Yamamoto K,Hasegawa Y,Kawai M,Kanazawa K,Fujiya T,Unno M,Katakura R

更新日期：2017-12-01 00:00:00