Platelet lysate embedded scaffolds for skin regeneration.

abstract：INTRODUCTION:RNA interference (RNAi) is a powerful mechanism for gene silencing with the potential to greatly impact the development of new therapies for many human diseases. Short interfering RNAs (siRNAs) may be the ideal molecules for therapeutic RNAi. However, therapeutic siRNAs face significant challenges that mus...

journal_title：Expert opinion on drug delivery

authors： McMahon KM,Thaxton CS

更新日期：2014-02-01 00:00:00

abstract：INTRODUCTION:For poorly soluble compounds, a good bioavailability is typically needed to assess the therapeutic index and the suitability of the compound for technical development. In industry, the selection of the delivery technology is not only driven by technical targets, but also by constraints, such as production ...

journal_title：Expert opinion on drug delivery

authors： van Hoogevest P,Liu X,Fahr A

更新日期：2011-11-01 00:00:00

abstract：INTRODUCTION:The identification of more efficient gene delivery vehicles (GDVs) is essential to fulfill the expectations of clinical gene therapy. Bacteriophages, due to their excellent safety profile, extreme stability under a variety of harsh environmental conditions and the capability for being genetically manipulat...

journal_title：Expert opinion on drug delivery

authors： Bakhshinejad B,Sadeghizadeh M

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:Many new drug substances have low aqueous solubility which can cause poor bioavailability after oral administration. The application of solid dispersions is a useful method to increase the dissolution rate of these drugs and thereby improve their bioavailability. So far, several methods have been developed...

journal_title：Expert opinion on drug delivery

authors： Srinarong P,de Waard H,Frijlink HW,Hinrichs WL

更新日期：2011-09-01 00:00:00

abstract：INTRODUCTION:Polymer-drug conjugates are an important part of polymer therapeutics. Recently, they have been used as an appealing platform for drug delivery. As a delivery vector, the route of administration performs a serious impact on the accessibility of drug molecules to their respective target site and therapeutic...

journal_title：Expert opinion on drug delivery

authors： Pang X,Yang X,Zhai G

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:The Aluetta™ reusable pen device and instructions for use (IFU) for growth hormone (r-hGH; Saizen®, Merck KGaA, Darmstadt, Germany) administration were tested for Human-Factors Usability, to ensure it could be used safely and effectively by the intended users in the intended use environment. RESEARCH DESIGN ...

journal_title：Expert opinion on drug delivery

authors： Cachemaille A,Warren SE,Moss S

更新日期：2020-07-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Recently, there has been substantial progress in the development of integrin targeted pharmaceuticals and drug delivery systems. Integrin is an important member in the cell adhesion molecule family, which is involved in regulation of complex biological conditions, from keeping normal physiologic...

journal_title：Expert opinion on drug delivery

authors： Wang Z,Chui WK,Ho PC

更新日期：2010-02-01 00:00:00

abstract：:Cancer is the second leading cause of death in the US. Currently, protocols for cancer treatment include surgery to remove diseased and suspect tissues, focused radiation, systemic chemotherapy, immunotherapy and their combinations. With conventional chemotherapy, it is almost impossible to deliver anticancer drugs sp...

journal_title：Expert opinion on drug delivery

authors： Xie Y,Bagby TR,Cohen MS,Forrest ML

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:Test the hypothesis that pegylated meglumine antimoniate-containing liposomes (LMA) and their mixture with non-pegylated (conventional) LMA may be more effective than conventional LMA against visceral leishmaniasis (VL), because of wider drug distribution among different mononuclear phagocyte system (MPS) tis...

journal_title：Expert opinion on drug delivery

authors： Azevedo EG,Ribeiro RR,da Silva SM,Ferreira CS,de Souza LE,Ferreira AA,de Oliveira E Castro RA,Demicheli C,Rezende SA,Frézard F

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:Sixty years since its introduction, 5-FU still forms the core of chemotherapy regimens for many types of malignancies. 5-FU is a time-dependent drug but is rapidly degraded in plasma by dihydropyrimidine dehydrogenase (DPD). Although originally developed in an intravenous form, 5-FU oral prodrugs were deve...

journal_title：Expert opinion on drug delivery

authors： Miura K,Shima H,Takebe N,Rhie J,Satoh K,Kakugawa Y,Satoh M,Kinouchi M,Yamamoto K,Hasegawa Y,Kawai M,Kanazawa K,Fujiya T,Unno M,Katakura R

更新日期：2017-12-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Cancer is the most formidable human disease. Owing to the heterogeneity of cancer, a single-treatment modality is insufficient for the complete elimination of cancer cells. Therapeutic strategies from various aspects are needed for cancer therapy. These therapeutic agents should be carefully sel...

journal_title：Expert opinion on drug delivery

authors： Kaneda Y

更新日期：2010-09-01 00:00:00

abstract：INTRODUCTION:Recent advances in pharmacological therapies to treat ocular diseases such as glaucoma, age-related macular degeneration, diabetic macular edema and retinal vascular occlusions have greatly improved the prognosis for these diseases. Due to these advances in pharmacological therapy, there is a great deal of...

journal_title：Expert opinion on drug delivery

authors： Kang-Mieler JJ,Osswald CR,Mieler WF

更新日期：2014-10-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Drug combinations have been the standard of care in the treatment of cancer for > 50 years. Typically, combination chemotherapy uses agents with non-overlapping toxicities which are escalated to their maximum tolerated dose. However, emerging evidence indicates that this approach may not be prov...

journal_title：Expert opinion on drug delivery

authors： Dicko A,Mayer LD,Tardi PG

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Augmentation of simvastatin (SMV) cytotoxicity in breast carcinoma cell lines MCF-7, by: improvement of cellular uptake and loading on alpha lipoic acid (ALA). METHODS:In this study, SMV was loaded on ALA nanoparticles and characterized for surface morphology, SMV entrapment efficiency percent (%EE), zeta p...

journal_title：Expert opinion on drug delivery

authors： Fahmy UA,Aljaeid BM

更新日期：2016-12-01 00:00:00

abstract：INTRODUCTION:Polymers can be designed to modify their features as a function of the level and nature of the surrounding microorganisms. Such responsive polymers can endow drug delivery systems and drug-medical device combination products with improved performance against intracellular infections and biofilms. AREAS CO...

journal_title：Expert opinion on drug delivery

authors： Alvarez-Lorenzo C,Garcia-Gonzalez CA,Bucio E,Concheiro A

更新日期：2016-08-01 00:00:00

abstract：:Cationic lipid/DNA complexes (lipoplexes) represent an attractive alternative to viral vectors for cell transfection in vitro and in vivo but still suffer from relatively low efficiency. Comprehension of the interactions between vectors and DNA as well as cellular pathways and mechanisms in DNA entry into cells and ul...

journal_title：Expert opinion on drug delivery

authors： Duan Y,Zhang S,Wang B,Yang B,Zhi D

更新日期：2009-12-01 00:00:00

abstract：INTRODUCTION:Recent developments in ultrasound imaging and ultrasound contrast agents (UCAs) improved diagnostic confidence in echography and set into motion their combined use as a tool for drug delivery and therapeutic monitoring. Non-invasive, precise and targeted delivery of drug molecules to pathological tissues b...

journal_title：Expert opinion on drug delivery

authors： Sennoga CA,Kanbar E,Auboire L,Dujardin PA,Fouan D,Escoffre JM,Bouakaz A

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Inhalation of microparticulate dosage forms can be effectively used in the treatment of respiratory and systemic diseases. OBJECTIVE:Disease states investigated for treatment by inhalation of microparticles were reviewed along with the drugs' pharmacological, pharmacokinetic and physical chemical properties...

journal_title：Expert opinion on drug delivery

authors： Xie Y,Zeng P,Wiedmann TS

更新日期：2008-03-01 00:00:00

abstract：:The advent of sophisticated drug delivery strategies for cancer applications has inundated the scientific and clinical community with new tactics and approaches such as molecular targeting, nanotechnology-based methods and personalized therapies. Unfortunately, the clinical impact has been moderate at best, falling si...

journal_title：Expert opinion on drug delivery

authors： Sakamoto J,Annapragada A,Decuzzi P,Ferrari M

更新日期：2007-07-01 00:00:00

abstract：:In the last decade, interest in physical organogels has grown rapidly with the discovery and synthesis of a very large number of diverse molecules, which can gel organic solvents at low concentrations. The gelator molecules immobilise large volumes of liquid following their self-assembly into a variety of aggregates s...

journal_title：Expert opinion on drug delivery

authors： Murdan S

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Increasing interest in digitally enhanced drug delivery tools urges both industry and academia to rethink current approaches to product usability testing. This article introduces mobile eye-tracking, generating detailed contextual data about user engagement with connected self-injection systems as a new meth...

journal_title：Expert opinion on drug delivery

authors： Lohmeyer Q,Schneider A,Jordi C,Lange J,Meboldt M

更新日期：2019-02-01 00:00:00

abstract：INTRODUCTION:Ultrasound enhancement of thrombolysis (sonothrombolysis) is further potentiated by administration of acoustically active microbubbles, which may be developed into powerful adjuvant therapies for thrombolytic treatment of occlusive conditions such as ischaemic stroke. AREAS COVERED:The role of microbubble...

journal_title：Expert opinion on drug delivery

authors： de Saint Victor M,Crake C,Coussios CC,Stride E

更新日期：2014-02-01 00:00:00

abstract：INTRODUCTION:Management of Osteoarthritis (OA) still is a challenge for clinicians. Taking into account a multidisciplinary approach including pharmacological and non-pharmacological treatments, intra-articular (IA) injection could be considered as an effective local therapy. Areas covered This review provides a new pe...

journal_title：Expert opinion on drug delivery

authors： Migliore A,Paoletta M,Moretti A,Liguori S,Iolascon G

更新日期：2020-09-01 00:00:00

abstract：INTRODUCTION:Nasal drug delivery that exploits the olfactory and trigeminal neuronal pathways to deliver drugs to the brain is being widely explored by pharmaceutical companies, for the delivery of challenging drugs. Low-molecular-weight and lipophilic drugs are effectively absorbed by the intranasal route for efficaci...

journal_title：Expert opinion on drug delivery

authors： Bahadur S,Pathak K

更新日期：2012-01-01 00:00:00

abstract：:Targeting vaccines to the skin epidermis results in the activation of an immune inductive site that is rich in antigen-presenting cells. The superficial location of the skin makes it accessible to vaccine delivery. However, it is difficult to access the epidermis using needle and syringe delivery, and vaccine antigens...

journal_title：Expert opinion on drug delivery

authors： Dean HJ

更新日期：2005-03-01 00:00:00

abstract：INTRODUCTION:Gemcitabine, an anticancer drug, is a nucleoside analog deoxycytidine antimetabolite, which acts against a wide range of solid tumors. The limitation of gemcitabine is its rapid inactivation by the deoxycytidine deaminase enzyme following its in vivo administration. AREAS COVERED:One of the most promising...

journal_title：Expert opinion on drug delivery

authors： Celia C,Cosco D,Paolino D,Fresta M

更新日期：2011-12-01 00:00:00

abstract：INTRODUCTION:Considering that the number of patients afflicted by posterior eye diseases is increasing, effective drug delivery is currently in high clinical demand. Topical administration has been identified as the preferred option, while sufferingfrom multiple barriers. The development of nanoparticle-based drug deli...

journal_title：Expert opinion on drug delivery

authors： Wang Y,Xu X,Gu Y,Cheng Y,Cao F

更新日期：2018-07-01 00:00:00

abstract：INTRODUCTION:Most pathogens colonize and invade the host at mucosal surfaces, such as the lung and the intestine. To combat intestinal pathogens the induction of local adaptive immune responses is required, which is mainly achieved through oral vaccination. However, most vaccines are ineffective when given orally owing...

journal_title：Expert opinion on drug delivery

authors： Devriendt B,De Geest BG,Cox E

更新日期：2011-04-01 00:00:00

abstract：INTRODUCTION:Glioblastoma is a type of brain cancer arises from glial cells. Glioblastoma multiforme (GBM), a subtype of glioblastoma, is the most common and most aggressive primary brain tumor. Currently, GBM therapy includes surgery and post-operative high-doses of radiation and chemotherapy. This therapeutic strateg...

journal_title：Expert opinion on drug delivery

authors： Gutkin A,Cohen ZR,Peer D

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:To develop orodispersible films (ODF) based on hydrophobic polymers with higher stability to ordinary environmental humidity conditions without compromising their fast disintegration time. METHODS:A quality by design approach was applied to screen three different formulations each one based on a different h...

journal_title：Expert opinion on drug delivery

authors： Borges AF,Silva BM,Silva C,Coelho JF,Simões S

更新日期：2016-10-01 00:00:00