Abstract:
INTRODUCTION:For poorly soluble compounds, a good bioavailability is typically needed to assess the therapeutic index and the suitability of the compound for technical development. In industry, the selection of the delivery technology is not only driven by technical targets, but also by constraints, such as production costs, time required for development and the intellectual property situation. AREAS COVERED:This review covers current developments in parenteral and oral delivery technologies and products for poorly water-soluble compounds, such as nano-suspensions, solid dispersions and liposomes. In addition, the use of biorelevant dissolution media to assess dissolution and solubility properties is described. Suggestions are also included to systematically address development hurdles typical of poorly water-soluble compounds intended for parenteral or oral administration. EXPERT OPINION:A holistic assessment is recommended to select the appropriate delivery technology by taking into account technical as well as intellectual property considerations. Therefore, first and foremost, a comprehensive physico-chemical characterization of poorly water-soluble compounds can provide the key for a successful selection and development outcome. In this context, the identified physical form of the compound in the formulation is used as a guide for a risk-benefit assessment of the selected oral delivery technology. The potential of nano-suspensions for intravenous administration is unclear. In the case of oral administration, nano-suspensions are mainly used to improve the oral absorption characteristics of micronized formulations. The development of an in situ instantaneous solubilization method, based on stable, standardized liposomes with low toxicity, opens new avenues to solubilize poorly water-soluble compounds.
journal_name
Expert Opin Drug Delivjournal_title
Expert opinion on drug deliveryauthors
van Hoogevest P,Liu X,Fahr Adoi
10.1517/17425247.2011.614228subject
Has Abstractpub_date
2011-11-01 00:00:00pages
1481-500issue
11eissn
1742-5247issn
1744-7593journal_volume
8pub_type
杂志文章,评审abstract:INTRODUCTION:Cancer is a leading cause of death worldwide and efficient new strategies are urgently needed to combat its high mortality and morbidity statistics. Fortunately, over the years, nanotechnology has evolved as a frontrunner in the areas of imaging, diagnostics and therapy, giving the possibility of monitorin...
journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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abstract:INTRODUCTION:Sixty years since its introduction, 5-FU still forms the core of chemotherapy regimens for many types of malignancies. 5-FU is a time-dependent drug but is rapidly degraded in plasma by dihydropyrimidine dehydrogenase (DPD). Although originally developed in an intravenous form, 5-FU oral prodrugs were deve...
journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章
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更新日期:2006-03-01 00:00:00
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章
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更新日期:2021-01-19 00:00:00
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
doi:10.1517/17425247.5.6.641
更新日期:2008-06-01 00:00:00
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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更新日期:2014-02-01 00:00:00
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug delivery
pub_type: 历史文章,杂志文章,评审
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journal_title:Expert opinion on drug delivery
pub_type: 杂志文章,评审
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journal_title:Expert opinion on drug delivery
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journal_title:Expert opinion on drug delivery
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