Cutaneous immunization: an evolving paradigm in influenza vaccines.

abstract：:Introduction: Pulmonary drug delivery is a complex field of research combining physics which drive aerosol transport and deposition and biology which underpins efficacy and toxicity of inhaled drugs. A myriad of preclinical methods, ranging from in-silico to in-vitro, ex-vivo and in-vivo, can be implemented.Areas cove...

journal_title：Expert opinion on drug delivery

authors： Ehrmann S,Schmid O,Darquenne C,Rothen-Rutishauser B,Sznitman J,Yang L,Barosova H,Vecellio L,Mitchell J,Heuze-Vourc'h N

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:The aim of this work is to synthesize a novel stable and biodegradable nitric oxide (NO) donor polymer based on a chitosan backbone. This polymer needed to be linked to glutathione (GSH), which was nitrosated in a second step. This polymer has been developed as an NO delivery platform that could be further e...

journal_title：Expert opinion on drug delivery

authors： Shah SU,Martinho N,Socha M,Pinto Reis C,Gibaud S

更新日期：2015-08-01 00:00:00

abstract：INTRODUCTION:Utilizing the prodrug approach as a method to overcome various pharmaceutical and pharmacokinetic barriers to drug delivery is significantly accelerating and achieving successes. In contrast to the older traditional prodrugs which suffer from decreased bioavailability and a high profile of side effects, du...

journal_title：Expert opinion on drug delivery

authors： Amly W,Karaman R

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Over the past several decades, liposomes have been used in a variety of applications, from delivery vehicles to cell membrane models. In terms of pharmaceutical use, they can offer control over the release of active agents encapsulated into their lipid bilayer or aqueous core, while providing protection fr...

journal_title：Expert opinion on drug delivery

authors： Bowey K,Tanguay JF,Tabrizian M

更新日期：2012-02-01 00:00:00

abstract：INTRODUCTION:Nasal drug delivery that exploits the olfactory and trigeminal neuronal pathways to deliver drugs to the brain is being widely explored by pharmaceutical companies, for the delivery of challenging drugs. Low-molecular-weight and lipophilic drugs are effectively absorbed by the intranasal route for efficaci...

journal_title：Expert opinion on drug delivery

authors： Bahadur S,Pathak K

更新日期：2012-01-01 00:00:00

abstract：INTRODUCTION:Even though pulmonary diseases are among the leading causes of morbidity and mortality in the world, exceedingly few life-prolonging therapies have been developed for these maladies. Relief may finally come from nanomedicine and targeted drug delivery. AREAS COVERED:Here, we focus on four conditions for w...

journal_title：Expert opinion on drug delivery

authors： Brenner JS,Greineder C,Shuvaev V,Muzykantov V

更新日期：2015-02-01 00:00:00

abstract：INTRODUCTION:Cancer is a leading cause of death worldwide and efficient new strategies are urgently needed to combat its high mortality and morbidity statistics. Fortunately, over the years, nanotechnology has evolved as a frontrunner in the areas of imaging, diagnostics and therapy, giving the possibility of monitorin...

journal_title：Expert opinion on drug delivery

authors： Luque-Michel E,Imbuluzqueta E,Sebastián V,Blanco-Prieto MJ

更新日期：2017-01-01 00:00:00

abstract：INTRODUCTION:Current treatment of malignant tumors relies predominantly on chemotherapy delivering a single antineoplastic drug or a combination of two or more drugs intravenously. Problems with such treatments can include the killing of healthy cells, adverse side effects and chemoresistance. As cancer basically resul...

journal_title：Expert opinion on drug delivery

authors： Chowdhury EH

更新日期：2011-03-01 00:00:00

abstract：INTRODUCTION:Gemcitabine, an anticancer drug, is a nucleoside analog deoxycytidine antimetabolite, which acts against a wide range of solid tumors. The limitation of gemcitabine is its rapid inactivation by the deoxycytidine deaminase enzyme following its in vivo administration. AREAS COVERED:One of the most promising...

journal_title：Expert opinion on drug delivery

authors： Celia C,Cosco D,Paolino D,Fresta M

更新日期：2011-12-01 00:00:00

abstract：INTRODUCTION:Transportation of the nutrients and other substances from the blood to the brain is selectively controlled by the brain capillary endothelial cells that form a restrictive barrier, so-called blood-brain barrier (BBB). Currently, there is no unimpeachable approach to overcome the BBB obstructiveness because...

journal_title：Expert opinion on drug delivery

authors： Jafari B,Pourseif MM,Barar J,Rafi MA,Omidi Y

更新日期：2019-06-01 00:00:00

abstract：INTRODUCTION:Interest in mesoporous silica nanoparticles for drug delivery has resulted in a good understanding of the impact of size and surface chemistry of these nanoparticles on their performance as drug carriers. Shape has emerged as an additional factor that can have a significant effect on delivery efficacy. Rod...

journal_title：Expert opinion on drug delivery

authors： Cong VT,Gaus K,Tilley RD,Gooding JJ

更新日期：2018-09-01 00:00:00

abstract：INTRODUCTION:Many new drug substances have low aqueous solubility which can cause poor bioavailability after oral administration. The application of solid dispersions is a useful method to increase the dissolution rate of these drugs and thereby improve their bioavailability. So far, several methods have been developed...

journal_title：Expert opinion on drug delivery

authors： Srinarong P,de Waard H,Frijlink HW,Hinrichs WL

更新日期：2011-09-01 00:00:00

abstract：INTRODUCTION:Macromolecular therapeutics, including enzymes, transcription factors, siRNAs, peptides and large synthetic molecules, can potentially be used to treat human diseases by targeting intracellular molecular pathways and modulating biological responses. However, large macromolecules have no ability to enter ce...

journal_title：Expert opinion on drug delivery

authors： Lönn P,Dowdy SF

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:The treatment of hard tissue defects, especially those of bone and cartilage, induced by infections or tumors remains challenging. Traditional methods, including debridement with systematic chemotherapy, have shortcomings owing to their inability to eliminate infections and high systematic toxicity. AREA ...

journal_title：Expert opinion on drug delivery

authors： Hua L,Lei T,Qian H,Zhang Y,Hu Y,Lei P

更新日期：2021-01-19 00:00:00

abstract：OBJECTIVE:Test the hypothesis that pegylated meglumine antimoniate-containing liposomes (LMA) and their mixture with non-pegylated (conventional) LMA may be more effective than conventional LMA against visceral leishmaniasis (VL), because of wider drug distribution among different mononuclear phagocyte system (MPS) tis...

journal_title：Expert opinion on drug delivery

authors： Azevedo EG,Ribeiro RR,da Silva SM,Ferreira CS,de Souza LE,Ferreira AA,de Oliveira E Castro RA,Demicheli C,Rezende SA,Frézard F

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:Overactive bladder affects a significant portion of the population and results in prescribing of numerous medications for its treatment. Traditional drug delivery systems used in therapy are associated with multiple commonly reported side effects. Adherence rates with use of these medications are low. It i...

journal_title：Expert opinion on drug delivery

authors： Scott K,Dmochowski RR,Padmanabhan P

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Skin disorders will continue to cause complications in patients. At present, there is an expansion of research into dermatologic treatment due to a critical need for new treatment options to treat skin diseases. AREAS COVERED:The skin itself provides a natural barrier against particle penetration for topi...

journal_title：Expert opinion on drug delivery

authors： Gupta M,Agrawal U,Vyas SP

更新日期：2012-07-01 00:00:00

abstract：INTRODUCTION:Nanomedicine has emerged as a major field of academic research with direct impact on human health. While a first generation of products has been successfully commercialized and has significantly contributed to enhance patient's life, recent advances in material design and the emergence of new therapeutics ...

journal_title：Expert opinion on drug delivery

authors： Ragelle H,Danhier F,Préat V,Langer R,Anderson DG

更新日期：2017-07-01 00:00:00

abstract：INTRODUCTION:Carbohydrates are key participants in many biological processes including reproduction, inflammation, signal transmission and infection. Their biocompatibility and ability to be recognized by cell-surface receptors illustrate their potential therapeutic applications. αYet, they are not ideal candidates bec...

journal_title：Expert opinion on drug delivery

authors： Sunasee R,Adokoh CK,Darkwa J,Narain R

更新日期：2014-06-01 00:00:00

abstract：INTRODUCTION:Lymphatic vessels are the preferential route of most solid tumors to spread their metastases in the body. The onset of metastatic nests in draining lymph nodes (LNs) are a significant indicator of cancer progression and a dismaying sign of worsen staging. Therefore, the individuation and elimination of can...

journal_title：Expert opinion on drug delivery

authors： Obinu A,Gavini E,Rassu G,Maestri M,Bonferoni MC,Giunchedi P

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Efficient and minimally invasive vector systems appear to be the most appropriate for both gene therapy and drug delivery. Numerous viral and non-viral vectors have been developed. Each vector has its own advantages and limitations. OBJECTIVE:New vectors have been required for overcoming the limitations of ...

journal_title：Expert opinion on drug delivery

authors： Kaneda Y

更新日期：2008-02-01 00:00:00

abstract：:Many agents used to treat cancer are toxic to normal tissues. Thus, treatments delivering drug specifically to tumour, while minimising exposure to normal tissue, may be advantageous over non-targeted treatments. The exquisite specificity of the immune system has been used successfully to help develop targeted antican...

journal_title：Expert opinion on drug delivery

authors： Brumlik MJ,Daniel BJ,Waehler R,Curiel DT,Giles FJ,Curiel TJ

更新日期：2008-01-01 00:00:00

abstract：:Oral colon-targeted drug delivery systems have gained enormous attention among researchers in the last two decades. The significance of this site-specific drug delivery system can be measured by its usefulness for delivering a variety of therapeutic agents, both for the treatment of local diseases or for systemic ther...

journal_title：Expert opinion on drug delivery

authors： Patel MM

更新日期：2011-10-01 00:00:00

abstract：INTRODUCTION:Transdermal drug delivery has several known advantages over the oral route and hypodermic injections. The number of drugs that can be taken up transdermally is, however, limited owing to the innate barrier function of the skin. New transdermal drug candidates need to be tested extensively before being used...

journal_title：Expert opinion on drug delivery

authors： Van Gele M,Geusens B,Brochez L,Speeckaert R,Lambert J

更新日期：2011-06-01 00:00:00

abstract：INTRODUCTION:Respiratory infections and diseases are accompanied by or exhibit inflammation. Recent advances in nanoparticle engineering technology, together with the increased knowledge of inflammatory pathophysiology, have ignited interest in the pulmonary delivery of anti-inflammatory agents (AIAs) to achieve local ...

journal_title：Expert opinion on drug delivery

authors： Ali ME,McConville JT,Lamprecht A

更新日期：2015-06-01 00:00:00

abstract：INTRODUCTION:Macrophages are involved in the normal defense of the body; however, the varying phenotypes of macrophages and imbalance in their ratio lead to the impairment of immune response initiating the production of inflammation. As the role of macrophages in immunological disorders and their surface receptors modu...

journal_title：Expert opinion on drug delivery

authors： Mukhtar M,Ali H,Ahmed N,Munir R,Talib S,Khan AS,Ambrus R

更新日期：2020-09-01 00:00:00

abstract：:Among the strategies developed for drug delivery into the CNS, locally controlled drug release by the way of an implantable polymeric device has been developed in recent years. The first polymeric devices developed were macroscopic implants needing open surgery for implantation. Over the last few years, poly(lactide-c...

journal_title：Expert opinion on drug delivery

authors： Menei P,Montero-Menei C,Venier MC,Benoit JP

更新日期：2005-03-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:The prediction of the in vivo drug release characteristics of modified release (MR) oral dosage forms by in vitro dissolution tests is a prerequisite for successful product development. AREAS COVERED IN THIS REVIEW:To improve the predictive power of dissolution testing, the authors recently dev...

journal_title：Expert opinion on drug delivery

authors： Garbacz G,Klein S,Weitschies W

更新日期：2010-11-01 00:00:00

abstract：INTRODUCTION:Fueled by a growing global expectation of the health and medical fields, billions of dollars/euros/pounds are invested every year in the research of new biological and chemical entities. However, little interest is seen in the development of novel drug delivery systems. One such system, pre-filled syringe ...

journal_title：Expert opinion on drug delivery

authors： Ingle RG,Agarwal AS

更新日期：2014-09-01 00:00:00

abstract：INTRODUCTION:Recent developments in ultrasound imaging and ultrasound contrast agents (UCAs) improved diagnostic confidence in echography and set into motion their combined use as a tool for drug delivery and therapeutic monitoring. Non-invasive, precise and targeted delivery of drug molecules to pathological tissues b...

journal_title：Expert opinion on drug delivery

authors： Sennoga CA,Kanbar E,Auboire L,Dujardin PA,Fouan D,Escoffre JM,Bouakaz A

更新日期：2017-09-01 00:00:00