MicroProteins: small size-big impact.

Abstract:

:MicroProteins (miPs) are short, usually single-domain proteins that, in analogy to miRNAs, heterodimerize with their targets and exert a dominant-negative effect. Recent bioinformatic attempts to identify miPs have resulted in a list of potential miPs, many of which lack the defining characteristics of a miP. In this opinion article, we clearly state the characteristics of a miP as evidenced by known proteins that fit the definition; we explain why modulatory proteins misrepresented as miPs do not qualify as true miPs. We also discuss the evolutionary history of miPs, and how the miP concept can extend beyond transcription factors (TFs) to encompass different non-TF proteins that require dimerization for full function.

journal_name

Trends Plant Sci

journal_title

Trends in plant science

authors

Eguen T,Straub D,Graeff M,Wenkel S

doi

10.1016/j.tplants.2015.05.011

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

477-82

issue

8

eissn

1360-1385

issn

1878-4372

pii

S1360-1385(15)00140-5

journal_volume

20

pub_type

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