Identifying the molecular basis of QTLs: eQTLs add a new dimension.

Abstract:

:Natural genetic variation within plant species is at the core of plant science ranging from agriculture to evolution. Whereas much progress has been made in mapping quantitative trait loci (QTLs) controlling this natural variation, the elucidation of the underlying molecular mechanisms has remained a bottleneck. Recent systems biology tools have significantly shortened the time required to proceed from a mapped locus to testing of candidate genes. These tools enable research on natural variation to move from simple reductionistic studies focused on individual genes to integrative studies connecting molecular variation at multiple loci with physiological consequences. This review focuses on recent examples that demonstrate how expression QTL data can be used for gene discovery and exploited to untangle complex regulatory networks.

journal_name

Trends Plant Sci

journal_title

Trends in plant science

authors

Hansen BG,Halkier BA,Kliebenstein DJ

doi

10.1016/j.tplants.2007.11.008

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

72-7

issue

2

eissn

1360-1385

issn

1878-4372

pii

S1360-1385(08)00024-1

journal_volume

13

pub_type

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