Cystathionine gamma-synthase and threonine synthase operate in concert to regulate carbon flow towards methionine in plants.

Abstract:

:The sulfur-containing amino acid methionine is a nutritionally important essential amino acid and is the precursor of several metabolites that regulate plant growth and responses to the environment. Methionine production is largely regulated by cystathionine gamma-synthase, the first specific enzyme for its synthesis. This enzyme competes in a complex manner with threonine synthase, the last enzyme in threonine biosynthesis, for their common substrate O-phosphohomoserine. New genetic and molecular data suggest that methionine synthesis and catabolism are coordinately regulated by novel post-transcriptional and post-translational mechanisms that are associated with a regulatory part within the N-terminal part of cystathionine gamma-synthase.

journal_name

Trends Plant Sci

journal_title

Trends in plant science

authors

Amir R,Hacham Y,Galili G

doi

10.1016/s1360-1385(02)02227-6

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

153-6

issue

4

eissn

1360-1385

issn

1878-4372

pii

S1360138502022276

journal_volume

7

pub_type

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