Viral suppressors of RNA silencing.

Abstract:

:The infection and replication of viruses in the host induce diverse mechanisms for combating viral infection. One of the best-studied antiviral defence mechanisms is based on RNA silencing. Consistently, several viral suppressors of RNA silencing (VSRs) have been identified from almost all plant virus genera, which are surprisingly diverse within and across kingdoms, exhibiting no obvious sequence similarities. VSRs efficiently inhibit host antiviral responses by interacting with the key components of cellular silencing machinery, often mimicking their normal cellular functions. Recent findings have revealed that the impact of VSRs on endogenous pathways is more complex and profound than had been estimated thus far. This review highlights the current understanding of and new insights into the mechanisms and functions of plant VSRs.

journal_name

Trends Plant Sci

journal_title

Trends in plant science

authors

Burgyán J,Havelda Z

doi

10.1016/j.tplants.2011.02.010

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

265-72

issue

5

eissn

1360-1385

issn

1878-4372

pii

S1360-1385(11)00045-8

journal_volume

16

pub_type

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