Plasticity of specialized metabolism as mediated by dynamic metabolons.

Abstract:

:The formation of specialized metabolites enables plants to respond to biotic and abiotic stresses, but requires the sequential action of multiple enzymes. To facilitate swift production and to avoid leakage of potentially toxic and labile intermediates, many of the biosynthetic pathways are thought to organize in multienzyme clusters termed metabolons. Dynamic assembly and disassembly enable the plant to rapidly switch the product profile and thereby prioritize its resources. The lifetime of metabolons is largely unknown mainly due to technological limitations. This review focuses on the factors that facilitate and stimulate the dynamic assembly of metabolons, including microenvironments, noncatalytic proteins, and allosteric regulation. Understanding how plants organize carbon fluxes within their metabolic grids would enable targeted bioengineering of high-value specialized metabolites.

journal_name

Trends Plant Sci

journal_title

Trends in plant science

authors

Laursen T,Møller BL,Bassard JE

doi

10.1016/j.tplants.2014.11.002

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

20-32

issue

1

eissn

1360-1385

issn

1878-4372

pii

S1360-1385(14)00289-1

journal_volume

20

pub_type

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