Bacteriophages and bacteriophage-derived endolysins as potential therapeutics to combat Gram-positive spore forming bacteria.

Abstract:

:Since their discovery in 1915, bacteriophages have been routinely used within Eastern Europe to treat a variety of bacterial infections. Although initially ignored by the West due to the success of antibiotics, increasing levels and diversity of antibiotic resistance is driving a renaissance for bacteriophage-derived therapy, which is in part due to the highly specific nature of bacteriophages as well as their relative abundance. This review focuses on the bacteriophages and derived lysins of relevant Gram-positive spore formers within the Bacillus cereus group and Clostridium genus that could have applications within the medical, food and environmental sectors.

journal_name

J Appl Microbiol

authors

Nakonieczna A,Cooper CJ,Gryko R

doi

10.1111/jam.12881

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

620-31

issue

3

eissn

1364-5072

issn

1365-2672

journal_volume

119

pub_type

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