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A novel zernike application to differentiate between three-dimensional corneal thickness of normal corneas and corneas with keratoconus.

Abstract：

PURPOSE:To evaluate a novel Zernike algorithm to differentiate 3-dimensional (3-D) corneal thickness distribution of corneas with keratoconus (KC) from normal corneas. DESIGN:A retrospective development and evaluation of a diagnostic approach. METHODS:Corneal tomography with Scheimpflug imaging was performed in normal (43 eyes) and KC (85 eyes) corneas. Axial and tangential cone location magnitude index (axial CLMI and tangential CLMI, respectively) of the anterior and posterior surface were calculated. The aberrations of the anterior corneal surface were analyzed with Zernike polynomials. Pachymetric Zernike analyses (PZA) were used to map the 3-D thickness distribution of the cornea. Logistic regression was performed to develop a diagnostic procedure for KC using CLMI, PZA, and aberrations. A receiver operating characteristic curve was constructed for each regression model. Corneal volume was also compared between normal and KC corneas. Only the central 5 mm zone was used for all analyses. RESULTS:Among the PZA coefficients, second- and third-order root mean squares of PZA coefficients were the best predictors of KC corneas (P < .0001). Among the CLMI variables, axial CLMI of anterior and tangential CLMI of posterior surface were the best predictors of KC (P < .0001). Among the Zernike corneal aberration coefficients, second- and third-order root mean squares of coefficients were the best predictors of KC (P < .0001). Sensitivity and specificity of Zernike corneal aberrations, CLMI, and PZA logistic regression model were similar (P > .05). CONCLUSIONS:The entire 3-D corneal thickness was mapped with Zernike. The PZA method was comparable to CLMI and anterior corneal wavefront aberrations in detecting KC.

journal_name

Am J Ophthalmol

journal_title

American journal of ophthalmology

authors

Shetty R,Matalia H,Srivatsa P,Ghosh A,Dupps WJ Jr,Sinha Roy A

doi

10.1016/j.ajo.2015.06.001

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

453-462.e2

issue

eissn

0002-9394

issn

1879-1891

pii

S0002-9394(15)00340-2

journal_volume

160

pub_type

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A novel zernike application to differentiate between three-dimensional corneal thickness of normal corneas and corneas with keratoconus.