Abstract:
BACKGROUND AND PURPOSE:Anxiety is potentially a pre-motor symptom of Parkinson's disease (PD). Our aim was to investigate the association between anxiety and subsequent PD risk in a population-based sample. METHODS:A total of 174 776 participants, who were free of prior PD, dementia and stroke, were enrolled from Taiwan National Health Insurance Research Database between 1 January 2005 and 31 December 2005. The association between anxiety at the beginning of the study and the incidence of PD was examined using a Cox regression model. Information regarding comorbidities, especially depression, and concomitant medication use was adjusted in the proportional hazards models. RESULTS:Over an average follow-up of 5.5 years, 2258 incident PD cases were diagnosed. After adjusting for age, sex, comorbidities and concomitant medication use, patients with anxiety were more likely to develop PD than subjects without anxiety [adjusted hazard ratio (HR) 1.38; 95% confidence interval (CI) 1.26-1.51]. Anxiety severity was dose-dependently associated with increased likelihood of PD: crude HR 1.27 (95% CI 1.11-1.44) for mild anxiety, 1.35 (95% CI 1.19-1.53) for moderate anxiety and 2.36 (95% CI 2.13-2.62) for severe anxiety (P < 0.0001). Results were similar after adjustment for age, sex, comorbid depression and other PD risk factors, and in the sensitivity analyses excluding participants with comorbid depression or with a PD diagnosis <3 years after anxiety diagnosis, and controlling for Charlson's scores. CONCLUSIONS:The likelihood of developing PD was greater amongst patients with anxiety than patients without anxiety, and the severity of anxiety correlated with risk of PD.
journal_name
Eur J Neuroljournal_title
European journal of neurologyauthors
Lin CH,Lin JW,Liu YC,Chang CH,Wu RMdoi
10.1111/ene.12740subject
Has Abstractpub_date
2015-09-01 00:00:00pages
1280-7issue
9eissn
1351-5101issn
1468-1331journal_volume
22pub_type
杂志文章abstract:BACKGROUND AND PURPOSE:Very-long-chain acyl-CoA dehydrogenase deficiency (VLCADD) is a hereditary disorder of mitochondrial long-chain fatty acid oxidation that has variable presentations, including exercise intolerance, cardiomyopathy and liver disease. The aim of this study was to describe the clinical and genetic ma...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14402
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Headache has been associated with various lifestyle and psychosocial factors, one of which is smoking. The aim of the present study was to investigate whether the association between smoking intensity and headache is likely to be causal. METHOD:A total of 58 316 participants from the Nord-Trønde...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13675
更新日期:2018-09-01 00:00:00
abstract::To determine the clinical features, prognostic factors, and therapeutic results of Guillain-Barré syndrome (GBS) in order to improve the therapeutic strategy for this disease. We retrospectively reviewed the electrodiagnostic study and medical records of patients with GBS admitted to Chang Gung Memorial Hospital, Kaoh...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2003.00683.x
更新日期:2003-11-01 00:00:00
abstract::We examined the peripheral-central sensory conduction by using somatosensory evoked potential (SEP) in a 48 year old diabetic patient with acute painful neuropathy. The sural, ulnar and median sensory nerve conduction and SEP elicited by wrist stimulation showed no abnormalities, nevertheless, the tibial nerve SEP rev...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.1996.tb00433.x
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Corticobasal syndrome (CBS) is a clinical entity characterized by higher cortical dysfunctions associated with asymmetric onset of levodopa-resistant parkinsonism, dystonia and myoclonus. One of the most typical and distressful features of CBS is limb apraxia, which affects patients in their ever...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12748
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Improved biomarkers are needed to facilitate clinical decision-making and as surrogate endpoints in clinical trials in multiple sclerosis (MS). We assessed whether neurodegenerative and neuroinflammatory markers in cerebrospinal fluid (CSF) at initial sampling could predict disease activity durin...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13274
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Charcot-Marie-Tooth (CMT) disease is a chronic, slowly progressing disorder. The lack of specific disease progression biomarkers limits the execution of clinical trials. However, neurofilament light chain (NfL) has been suggested as a potential biomarker for peripheral nervous system disorders. ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14689
更新日期:2020-12-19 00:00:00
abstract:BACKGROUND:Peritumoral brain edema in glioblastoma patients is a frequently encountered phenomenon that strongly contributes to neurological signs and symptoms. The role of peritumoral edema as a prognostic factor is controversial. MATERIALS AND METHODS:This multi-centre clinical retrospective study included 110 patie...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2009.02613.x
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Many patients with multiple sclerosis (MS) present swallowing difficulties. Dysphagia is associated with significant morbidity and mortality, has a profound impact on the quality of life but is under-reported by patients. The objective was to investigate the psychometric properties of the Dysphag...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14219
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Migraine is a common neurological disorder. It can be divided into episodic migraine (EM) and chronic migraine (CM), based on headache frequency. Some studies have shown that insulin sensitivity is impaired in migraine; moreover, hypertension, diabetes and obesity are common in patients with CM. ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.12289
更新日期:2014-02-01 00:00:00
abstract::In recent years, a number of potential new therapeutic indications of botulinum toxin injections have emerged, amongst which sialorrhea has attracted considerable attention. Based on open-label and controlled studies, botulinum toxin can be used to improve sialorrhea in patients with Parkinson's disease, parkinsonian ...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/j.1468-1331.2006.01447.x
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Charcot-Marie-Tooth (CMT) 1C due to mutations in LITAF/SIMPLE is a rare subtype amongst the autosomal dominant demyelinating forms of CMT. Our objective was to report the clinical and electrophysiological characteristics of 18 CMT1C patients and compare them to 20 patients with PMP22 mutations: 1...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13239
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Paraprotein-associated neuropathies have heterogeneous clinical, neurophysiological, neuropathological and haematological features. Objectives. To prepare evidence-based and consensus guidelines on the clinical management of patients with both a demyelinating neuropathy and a paraprotein (paraproteinaemic de...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2006.01467.x
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The role of cardiovascular risk factors in the pathogenesis of cognitive impairment and dementia remains still unclear. We examined the impact of cardiovascular risk factors on cognitive function in a large longitudinal population study. METHODS:Subjects were 5033 stroke-free men and women who p...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2010.03263.x
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Several metabolic derangements associated with diabetes mellitus type 2 (DM) have been associated with a better outcome in amyotrophic lateral sclerosis (ALS), including hyperlipidemia and obesity. Here, we tested the hypothesis that DM would have a positive effect on the motor and cognitive findings of ALS....
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2009.02923.x
更新日期:2010-05-01 00:00:00
abstract::A recently symptomatic carotid artery stenosis carries a high risk of subsequent ischaemic events and thus requires rapid treatment. We investigated the influence of the time delay between the last symptomatic event of a carotid stenosis and subsequent carotid artery stenting (CAS) with respect to the combined 30-day ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2007.02002.x
更新日期:2008-01-01 00:00:00
abstract::There are at least seven clinically indistinguishable but genetically different types of autosomal dominant pure spastic paraplegia (ADPSP). In this study we investigated electrophysiological characteristics in patients with ADPSP linked to chromosome 2p (SPG4). Twelve patients from six different families with ADPSP l...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1046/j.1468-1331.2001.00249.x
更新日期:2001-07-01 00:00:00
abstract::The natural history of thymoma remains unpredictable because of the possibility of recurrence not infrequent after resection, but generally confined to the mediastinum Rufini et al. (1997). ...
journal_title:European journal of neurology
pub_type: 信件
doi:10.1046/j.1468-1331.2000.00023.x
更新日期:2000-01-01 00:00:00
abstract::Epilepsies are amongst the most frequent chronic neurological conditions. Patients suffer from spontaneously recurring seizures because of sudden extensive electrical gray matter discharges. Although the current drug therapy allows many patients at least some degree of a satisfying course of the disease, a substantial...
journal_title:European journal of neurology
pub_type: 杂志文章,评审
doi:10.1111/j.1468-1331.2007.01706.x
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim was to study the prevalence of epilepsy in a hospital-based systemic lupus erythematosus (SLE) cohort and to investigate the relationship between epilepsy and other manifestations of neuropsychiatric SLE (NPSLE). METHODS:The study population consisted of 440 SLE patients recruited from 1...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14077
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Ataxia-telangiectasia (A-T) is a rare neurodegenerative disease, due to A-T mutated (ATM) gene mutations, which typically presents with signs of progressive neurological dysfunction, cerebellar ataxia and uncoordinated movements. A-T severely affects patients' quality of life. Successful treatmen...
journal_title:European journal of neurology
pub_type: 杂志文章,多中心研究
doi:10.1111/ene.13606
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE: Although fatigue is recognized as a common and debilitating symptom in patients with Parkinson's disease (PD), little is known on how and when this symptom emerges during disease progression. The aim of the study was to explore the presence and severity of fatigue in patients with PD at the tim...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2012.03663.x
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In multiple sclerosis (MS), disease-related factors and dysfunctional coping might favor the development of mental distress induced by COVID-19 containment measures. Aim of this study was exploring the relationship between disability, coping strategies, daily life reorganization and neuropsychiat...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.14580
更新日期:2020-10-11 00:00:00
abstract:BACKGROUND AND PURPOSE:Body mass index (BMI), hyperglycaemia and type 2 diabetes and their interactive effects are associated with brain volume atrophy in ageing. It remains to be established if these risk factors are particularly concerning in individuals with high or low brain volumes. METHODS:Demographics, venous b...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13780
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Blood pressure (BP) levels in acute intracerebral hemorrhage (ICH) and mortality have not been thoroughly studied in the young. METHODS:The relationship between BP and mortality was assessed in consecutive patients with first-ever, non-traumatic acute ICH at ≤50 years of age, enrolled in the Hel...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/ene.13662
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Patients with acute ischemic stroke are at high-risk for contracting COVID-19 infection. Additionally, healthcare professionals including neurovascular ultrasound providers are also at risk of being infected by SARS-CoV-2 virus. Yet, preparedness to continue to guarantee hyperacute treatment is v...
journal_title:European journal of neurology
pub_type: 杂志文章,实务指引
doi:10.1111/ene.14334
更新日期:2020-09-01 00:00:00
abstract::Treatment outcome in patients with neuropathic pain (NP) is often variable and disappointing. We tested the hypothesis that patients with clear evidence of nervous system lesion respond better to pharmacological treatment with documented effect on NP than patients with poor or no evidence of nervous system lesion. Fur...
journal_title:European journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1468-1331.2004.00843.x
更新日期:2004-08-01 00:00:00
abstract::The aim of this study was to compare the clinically based prevalence of myasthenia gravis (MG) with the prevalence of laboratory-confirmed cases. All patients with a diagnosis of MG living in Estonia as on 1 January 1997 were asked to participate in re-examination. The criteria for laboratory-supported MG were weaknes...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.2007.02038.x
更新日期:2008-03-01 00:00:00
abstract::Twelve patients with early Parkinson's disease (PD), none of whom had received any previous L-DOPA treatment, but using other antiparkinsonian drugs, were studied using transcranial magnetic stimulation (TMS). Contralateral and ipsilateral hemispheres were examined, with a focus on the more pronounced parkinsonian sym...
journal_title:European journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1046/j.1468-1331.2003.00610.x
更新日期:2003-07-01 00:00:00
abstract::Eur J Neurol 6:113 Copyright Lippincott Williams & Wilkins ...
journal_title:European journal of neurology
pub_type: 杂志文章
doi:10.1111/j.1468-1331.1999.tb00001.x
更新日期:1999-03-01 00:00:00