Type 2 diabetes mellitus and microvascular complications 1 year after Roux-en-Y gastric bypass: a case-control study.

abstract：AIMS/HYPOTHESIS:This 52-week multinational, randomised, open-label, parallel-group, non-inferiority trial compared clinical outcomes following supplementation of oral glucose-lowering drugs with basal insulin analogues detemir and glargine in type 2 diabetic patients. METHODS:Insulin-naive adults (n=582, HbA(1c) 7.5-1...

journal_title：Diabetologia

authors： Rosenstock J,Davies M,Home PD,Larsen J,Koenen C,Schernthaner G

更新日期：2008-03-01 00:00:00

abstract：:Obesity, which has long since reached epidemic proportions worldwide, is associated with long-term stress to a variety of organs and results in diseases including type 2 diabetes. In the brain, overnutrition induces hypothalamic stress associated with the activation of several signalling pathways, together with centra...

journal_title：Diabetologia

authors： Nogueiras R,Sabio G

更新日期：2021-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:A natural cofactor of mitochondrial dehydrogenase complexes and a potent antioxidant, alpha-lipoic acid improves glucose metabolism in people with Type II (non-insulin-dependent) diabetes mellitus and in animal models of diabetes. In this study we investigated the cellular mechanism of action of alpha-l...

journal_title：Diabetologia

authors： Yaworsky K,Somwar R,Ramlal T,Tritschler HJ,Klip A

更新日期：2000-03-01 00:00:00

abstract：AIMS/HYPOTHESIS:Studies have identified an association between diabetes and breast cancer in postmenopausal women in Western countries. Such an association needs to be confirmed in an Asian population. The aim of this study was to evaluate the secular trend for breast cancer mortality in Taiwanese women in the general ...

journal_title：Diabetologia

authors： Tseng CH,Chong CK,Tai TY

更新日期：2009-02-01 00:00:00

abstract：:In perifused pancreatic islets, the fluorescence of oxidized flavoproteins (FAD) was recorded continuously. Elevation of glucose concentration in the medium form 0 or 5 mM to 20 mM led to decrease in FAD-fluorescence beginning 10 sec after change of medium. L-leucine (10 mM), (+/-)-B-BCH (20 mM) and alpha-ketoisocapro...

journal_title：Diabetologia

authors： Panten U,Ishida H

更新日期：1975-12-01 00:00:00

abstract：:The pO2 at which haemoglobin is half-saturated with oxygen (p50) was determined at fixed pCO2 (45 mmHg) and without altering the resulting pH and the level of organic phosphates in heparinized whole blood samples from 26 diabetic patients and 24 normal subjects of both sexes. Diabetic blood p50 was higher (29.79 +/- 1...

journal_title：Diabetologia

authors： Samaja M,Melotti D,Carenini A,Pozza G

更新日期：1982-11-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type I (insulin-dependent) diabetes mellitus is associated with an increased extracellular volume. Sodium restriction might seem a logical form of treatment but data on its renal effects is conflicting. We therefore studied the effects of sodium restriction on renal haemodynamics in uncomplicated Type I...

journal_title：Diabetologia

authors： Luik PT,Hoogenberg K,Van Der Kleij FG,Beusekamp BJ,Kerstens MN,De Jong PE,Dullaart RP,Navis GJ

更新日期：2002-04-01 00:00:00

abstract：:The characteristics of familial Type I (insulin-dependent) diabetes mellitus-that is Type I diabetes in a first degree relative were investigated for children diagnosed before the age of 15 years using data from an international network of population-based registries (the EURODIAB ACE network) and from a case-control ...

journal_title：Diabetologia

authors：

更新日期：1998-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:We aimed to examine risk factors for, and differences in, renal failure in diabetic patients from 10 centres. METHODS:Risk factors for renal failure were examined in 3,558 diabetic patients who did not have renal disease at baseline in the WHO Multinational Study of Vascular Disease in Diabetes (WHO MS...

journal_title：Diabetologia

authors： Colhoun HM,Lee ET,Bennett PH,Lu M,Keen H,Wang SL,Stevens LK,Fuller JH

更新日期：2001-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:The aim of this study was to study differences in the prevalence of the metabolic syndrome and its associations with prevalent CHD according to ethnicity and sex. METHODS:We performed a combined analysis of two population-based cross-sectional studies conducted between 1988 and 1991 that followed ident...

journal_title：Diabetologia

authors： Tillin T,Forouhi N,Johnston DG,McKeigue PM,Chaturvedi N,Godsland IF

更新日期：2005-04-01 00:00:00

abstract：:Isloated rat islets were maintained in vitro in a perifusion system, exposed to alloxan (20 mg/100 ml) for 5 minutes in the presence of agents which affect cAMP metabolism and subsequently stimulated with glucose. The rate of insulin secretion was monitored throughout the period of perifusion. Exposure to alloxan alon...

journal_title：Diabetologia

authors： Lacy PE,McDaniel ML,Fink CJ,Roth C

更新日期：1975-12-01 00:00:00

abstract：:An incidence of 9.0 out of 100,000 children under 19 years of age with Type 1 (insulin-dependent) diabetes was detected in Toronto during a 2 year prospective study. An increased number of cases occurred in the winter months of one of the years but not of the other during the study. The annual incidence was the same i...

journal_title：Diabetologia

authors： Ehrlich RM,Walsh LJ,Falk JA,Middleton PJ,Simpson NE

更新日期：1982-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type 1 diabetes is an autoimmune disorder characterised by loss of insulin-producing beta cells of the pancreas. Progress in understanding the cellular and molecular mechanisms underlying the human disease has been hampered by a dearth of appropriate human experimental models. We previously reported the...

journal_title：Diabetologia

authors： Joshi K,Elso C,Motazedian A,Labonne T,Schiesser JV,Cameron F,Mannering SI,Elefanty AG,Stanley EG

更新日期：2019-12-01 00:00:00

abstract：AIMS/HYPOTHESIS:Results from animal models and some clinical work suggest a role for the central nervous system (CNS) in glucose regulation and type 2 diabetes pathogenesis by modulation of glucoregulatory hormones and the autonomic nervous system (ANS). The aim of this study was to characterise the neuroendocrine resp...

journal_title：Diabetologia

authors： Lundqvist MH,Almby K,Wiklund U,Abrahamsson N,Kamble PG,Pereira MJ,Eriksson JW

更新日期：2020-11-26 00:00:00

abstract：AIMS/HYPOTHESIS:The therapeutic benefit of physical activity to prevent and treat type 2 diabetes is commonly accepted. However, the impact of the disease on the acute metabolic response is less clear. To this end, we investigated the effect of type 2 diabetes on exercise-induced plasma metabolite changes and the muscu...

journal_title：Diabetologia

authors： Hansen JS,Zhao X,Irmler M,Liu X,Hoene M,Scheler M,Li Y,Beckers J,Hrabĕ de Angelis M,Häring HU,Pedersen BK,Lehmann R,Xu G,Plomgaard P,Weigert C

更新日期：2015-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:The enzyme hormone-sensitive lipase (HSL) is produced and is active in pancreatic beta cells. Because lipids are known to play a crucial role in normal control of insulin release and in the deterioration of beta cell function, as observed in type 2 diabetes, actions of HSL in beta cells may be critical....

journal_title：Diabetologia

authors： Fex M,Haemmerle G,Wierup N,Dekker-Nitert M,Rehn M,Ristow M,Zechner R,Sundler F,Holm C,Eliasson L,Mulder H

更新日期：2009-02-01 00:00:00

abstract：:A controlled trial of oral nicotinamide to prevent the onset of diabetes mellitus in high risk children was conducted in two centres. The selection criteria were age less than 16 years, islet cell antibody greater than or equal to 80 IUs, and first phase insulin release less than 5th percentile. All of eight untreated...

journal_title：Diabetologia

authors： Elliott RB,Chase HP

更新日期：1991-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:To determine whether the clinical heterogeneity observed in the development of Type I (insulin-dependent) diabetes mellitus correlates with immunohistochemical differences observed at diagnosis. METHODS:Patients (n = 17) with recent-onset diabetes clinically considered to be insulin dependent (Type I),...

journal_title：Diabetologia

authors： Imagawa A,Hanafusa T,Itoh N,Waguri M,Yamamoto K,Miyagawa J,Moriwaki M,Yamagata K,Iwahashi H,Sada M,Tsuji T,Tamura S,Kawata S,Kuwajima M,Nakajima H,Namba M,Matsuzawa Y

更新日期：1999-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Type I (insulin-dependent) diabetes mellitus is characterised by leucocyte infiltration of pancreatic islets and a progressive destruction of insulin-producing beta cells. As endothelial nitric oxide production is known to regulate adhesion molecule expression and leucocyte permeation, we examined the a...

journal_title：Diabetologia

authors： Suschek CV,Bonmann E,Kolb-Bachofen V

更新日期：1999-04-01 00:00:00

abstract：AIMS/HYPOTHESIS:In type 1 diabetes, selective beta cell loss occurs within the inflamed milieu of insulitic islets. This milieu is generated via the enhanced secretion of proinflammatory cytokines and by the loss of anti-inflammatory molecules such as IL-4 and IL-13. While the actions of proinflammatory cytokines have ...

journal_title：Diabetologia

authors： Leslie KA,Russell MA,Taniguchi K,Richardson SJ,Morgan NG

更新日期：2019-01-01 00:00:00

abstract：AIMS/HYPOTHESIS:Exposure to sunlight has the potential to suppress metabolic dysfunction and obesity. We previously demonstrated that regular exposure to low-doses of ultraviolet radiation (UVR) reduced weight gain and signs of diabetes in male mice fed a high-fat diet, in part via release of nitric oxide from skin. He...

journal_title：Diabetologia

authors： Dhamrait GK,Panchal K,Fleury NJ,Abel TN,Ancliffe MK,Crew RC,Croft K,Fernandez BO,Minnion M,Hart PH,Lucas RM,Mark PJ,Feelisch M,Weller RB,Matthews V,Gorman S

更新日期：2020-01-01 00:00:00

abstract：:Previous study have reported a significant improvement of peripheral neuropathy following combined pancreas and kidney transplantation attributed to improvement of blood glucose control by some authors and to elimination of uraemia by others. To asses the specific role of uraemia and hyperglycaemia in neuropathy, 16 d...

journal_title：Diabetologia

authors： Comi G,Galardi G,Amadio S,Bianchi E,Secchi A,Martinenghi S,Caldara R,Pozza G,Canal N

更新日期：1991-08-01 00:00:00

abstract：:The effect of interference with diacylglycerol metabolism was investigated in pancreatic mouse islets. In the presence of the diacylglycerol lipase inhibitor RHC 80,267, glucose-induced insulin secretion was reduced 50-60%; whereas carbacholin-induced insulin secretion was unaffected. Addition of the diacylglycerol ki...

journal_title：Diabetologia

authors： Capito K,Hansen SE,Hedeskov CJ,Thams P

更新日期：1989-02-01 00:00:00

abstract：AIMS/HYPOTHESIS:Highly active antiretroviral therapy (HAART) in patients infected with human immunodeficiency virus (HIV) is associated with a poorly understood lipodystrophic and hypertriglyceridaemic syndrome, which resembles Cushing's syndrome, but in which plasma cortisol is not elevated. We tested the hypothesis t...

journal_title：Diabetologia

authors： Sutinen J,Kannisto K,Korsheninnikova E,Nyman T,Ehrenborg E,Andrew R,Wake DJ,Hamsten A,Walker BR,Yki-Järvinen H

更新日期：2004-10-01 00:00:00

abstract：AIMS/HYPOTHESIS:Impaired glucose uptake in skeletal muscle is an important contributor to glucose intolerance in type 2 diabetes. The aspartate protease, beta-site APP-cleaving enzyme 1 (BACE1), a critical regulator of amyloid precursor protein (APP) processing, modulates in vivo glucose disposal and insulin sensitivit...

journal_title：Diabetologia

authors： Hamilton DL,Findlay JA,Montagut G,Meakin PJ,Bestow D,Jalicy SM,Ashford ML

更新日期：2014-08-01 00:00:00

abstract：AIMS/HYPOTHESIS:Although obesity is a major risk factor for diabetes, little is known about weight gain trajectories across adulthood, and whether they are differentially associated with metabolic markers of diabetes. METHODS:We used fasting blood samples and longitudinal weight data for 5,436 adults (5,734 observatio...

journal_title：Diabetologia

authors： Gordon-Larsen P,Koehler E,Howard AG,Paynter L,Thompson AL,Adair LS,Mayer-Davis EJ,Zhang B,Popkin BM,Herring AH

更新日期：2014-09-01 00:00:00

abstract：AIMS/HYPOTHESIS:Previous studies show that inflammatory cytokines play a part in the development of insulin resistance. Thiazolidinediones were developed as insulin-sensitizing drugs and are ligands for the peroxisome proliferator-activated receptory (PPARgamma). We hypothesized that the anti-diabetic mechanism of thia...

journal_title：Diabetologia

authors： Tanaka T,Itoh H,Doi K,Fukunaga Y,Hosoda K,Shintani M,Yamashita J,Chun TH,Inoue M,Masatsugu K,Sawada N,Saito T,Inoue G,Nishimura H,Yoshimasa Y,Nakao K

更新日期：1999-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Elevated circulating adipocyte fatty acid-binding protein (AFABP) levels have been found to correlate with diabetic nephropathy staging in cross-sectional studies. However, it remains unclear whether these higher serum levels reflect a role of AFABP in the development of diabetic kidney disease (DKD), o...

journal_title：Diabetologia

authors： Lee CH,Cheung CYY,Woo YC,Lui DTW,Yuen MMA,Fong CHY,Chow WS,Xu A,Lam KSL

更新日期：2019-01-01 00:00:00

abstract：:We describe a patient who had an anaphylactic reaction to highly purified pork insulin; he was not allergic however to beef insulin. The sensitivity to pork but not to beef insulin was confirmed by skin testing, radioallergosorbent test (RAST) and RAST inhibition. A scheme is suggested for the investigation of such pa...

journal_title：Diabetologia

authors： Carini C,Brostoff J,Kurtz AB

更新日期：1982-05-01 00:00:00

abstract：:Short- and long-term regulation of hepatic carbohydrate metabolism by insulin-like growth factor II was studied in primary cultures of adult rat hepatocytes and compared to the metabolic potency of insulin. Insulin-like growth factor II stimulated glycogen synthesis from [14C]glucose, uptake of [3H]aminoisobutyric aci...

journal_title：Diabetologia

authors： Hartmann H,Meyer-Alber A,Braulke T

更新日期：1992-03-01 00:00:00