Concomitant neuroendocrine tumor and gastrointestinal stromal tumor in a duodenal fine needle aspiration: A cytologic clue for neurofibromatosis type 1.

Abstract:

:The identification of two cell populations displaying different cytologic characteristics in the same fine needle aspiration (FNA), one with an epithelioid appearance and the other spindle cell morphology, is an extremely rare phenomenon and potentially represents a source of diagnostic confusion. Depending on the lineage and relationship of the two cell types, the differential diagnosis is broad and encompasses a wide spectrum of entities. The current case describes the presence of nests and clusters of neuroendocrine cells associated with rare spindle cell fragments of gastrointestinal stromal tumor (GIST) in the same fine needle aspiration of a duodenal mass. Our literature analysis revealed that such combined cytologic findings were hitherto never reported and the concurrence of well-differentiated neuroendocrine tumor (NET) and GIST is almost pathognomonic for neurofibromatosis type 1 (NF-1).

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Tran TAN,Rosales A,Arnoletti JP,Ouyang J,Hasan MK

doi

10.1002/dc.24579

subject

Has Abstract

pub_date

2021-02-01 00:00:00

pages

E45-E48

issue

2

eissn

8755-1039

issn

1097-0339

journal_volume

49

pub_type

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