Pancreatic adenocarcinoma: regression analysis to identify improved cytologic criteria.

Abstract:

:The incidence of pancreatic adenocarcinoma is increasing and it is usually unresectable at the time of diagnosis. Consequently, fine-needle aspiration biopsy (FNAB) is being used more frequently for diagnosis. The reported sensitivity of diagnosing pancreatic adenocarcinoma by FNAB has varied between 50% and 100%. In an attempt to increase the diagnostic sensitivity, we retrospectively reviewed a series of pancreatic FNABs. Fifteen cytologic criteria were evaluated in 78 patients who had pancreatic FNABs. Of these patients, 49 had primary adenocarcinomas and 29 had benign, non-neoplastic lesions. Using a stepwise logistic regression analysis we identified three key cytologic criteria for this diagnosis. Our study identified anisonucleosis (P = 0.001), large nuclei (P = .007), and nuclear molding (P = .03) as the significant cytologic features for diagnosing pancreatic adenocarcinoma. In combination, these three criteria had a sensitivity of 98% and a specificity of 100%.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Cohen MB,Egerter DP,Holly EA,Ahn DK,Miller TR

doi

10.1002/dc.2840070404

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

341-5

issue

4

eissn

8755-1039

issn

1097-0339

journal_volume

7

pub_type

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