Metastatic small cell osteosarcoma to the liver: a diagnostic pitfall for fine-needle aspiration cytology.


:We report the fine-needle aspiration cytology of a case of metastatic small cell osteosarcoma to the liver with rosette formation, originating from distal femur, in a 36-year-old female. The aspirate of the liver metastases revealed a relatively monomorphic population of mitotically active small blue round cells arranged in clusters with prominent rosette formation simulating a neuroendocrine carcinoma or other rosette-forming small round cell tumors such as Ewing sarcoma. No extracellular mineralized matrix material was present. Comparison of the liver aspirate with the biopsy from the distal femoral lesion was crucial in reaching the correct diagnosis of metastatic small cell osteosarcoma with rosette formation. This is a potential diagnostic pitfall, particularly if interpreted without the knowledge of a suspected primary bone tumor.


Diagn Cytopathol


Diagnostic cytopathology


Ali RH,Lee CH,Hayes MM




Has Abstract


2014-02-01 00:00:00












  • Immunoreactivity of prostate-specific antigen in male breast carcinomas: two examples of a diagnostic pitfall in discriminating a primary breast cancer from metastatic prostate carcinoma.

    abstract::Prostatic-specific antigen (PSA) is regarded as a specific marker secreted by normal and neoplastic acinar epithelial cells of the prostate gland; its detection by immunocytochemistry has been accepted as an indication of metastatic prostate cancer. This is ascribed to the commonly held belief that PSA is not found in...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Gupta RK

    更新日期:1999-09-01 00:00:00

  • Fine-needle aspiration cytology of ameloblastoma and malignant ameloblastoma: a study of 12 cases.

    abstract::Ameloblastoma is an odontogenic tumor with aggressive biological behavior, high recurrence rate, and a complex microscopic appearance with many different histologic patterns. Primary ameloblastoma is also described in extragnathic locations. Because of its wide morphologic spectrum, which is mirrored also in cytologic...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Klapsinou E,Stavros A,Smaragda A,Despoina P,Dimitra D

    更新日期:2013-03-01 00:00:00

  • Follicular lesions of the thyroid: a retrospective study of 1,348 fine needle aspiration biopsies.

    abstract::Fine needle aspiration (FNA) has proven to be an effective tool in management of patients with thyroid nodules. However, the diagnosis of follicular patterned lesions can be challenging. The surgical and cytopathology computer database at a large referral medical center was searched for cases that had both cytologic a...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Wu S,DeMay RM,Papas P,Yan B,Reeves W

    更新日期:2012-05-01 00:00:00

  • Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): diagnosis with fine-needle aspiration in a case with nodal and nasal involvement.

    abstract::Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare entity characterized by the proliferation of cells belonging to the macrophage-histiocyte family, but whose exact origin is unknown. A case of SHML occurring in a 62-yr-old female is described in which the diagnosis is initially suggested by fine-needle...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Alvarez Alegret R,Martinez Tello A,Ramirez T,Gállego P,Martinez D,García Julían G

    更新日期:1995-11-01 00:00:00

  • Metastatic melanoma of the uterine cervix diagnosed on cervical Pap smear: Case report and literature review.

    abstract::Metastatic cancer involving the uterine cervix is exceedingly rare, and accounts for less than 1% of cancer deaths. The cervix is an uncommon location for metastatic lesions due to its limited blood supply and fibrous stroma and metastatic melanoma of the cervix is particularly infrequent. To the best of our knowledge...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Shachner TR,Van Meter SE

    更新日期:2018-12-01 00:00:00

  • High-grade endometrial stromal sarcoma with smooth muscle and skeletal muscle differentiation: report of a case with cytomorphologic and immunocytologic analysis.

    abstract::We report a case of high-grade endometrial stromal sarcoma with cytological and immunocytochemical findings. Cytologically, major tumor cells showed round-to-short spindle shapes with round- to oval-shaped nuclei and moderately abundant delicate cytoplasm. Tumor cells with tapered shapes and eccentric nuclei were also...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Ohta Y,Suzuki T,Kojima T,Mikogami T,Omatsu M,Hamatani S,Shiokawa A,Kushima M,Ota H

    更新日期:2011-04-01 00:00:00

  • Applications of flow cytometric DNA analysis to diagnostic cytology.

    abstract::Flow cytometry is a rapid method for measuring DNA content. Its high sensitivity and specificity in detecting transitional cell carcinomas in bladder washings should make it a routinely applied adjunct to cytology once universal laboratory standards are firmly established. Diagnostic and prognostic information on soli...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: Cibas ES

    更新日期:1995-08-01 00:00:00

  • Malignant mixed tumor (carcinosarcoma) of parotid gland diagnosed by fine-needle aspiration biopsy.

    abstract::True malignant mixed tumor (carcinosarcoma) of salivary gland is a very rare neoplasm. Only one brief account of the Fine-Needle Aspiration Biopsy (FNAB) cytologic findings of this tumor was found in the literature. The authors report a case of malignant mixed tumor (chondrosarcoma and epidermoid carcinoma) arising fr...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Granger JK,Houn HY

    更新日期:1991-01-01 00:00:00

  • Endoscopic ultrasonography-fine needle aspiration of solid pancreatic masses: Do we need the fourth pass? A prospective study.

    abstract:BACKGROUND:Endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) is important for the differential diagnosis of solid pancreatic lesions. Sample adequacy is related to the number of needle passes, and European guidelines recommend three to four needle passes with a standard EUS-FNA needle. We aimed to eval...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Teodorescu C,Gheorghiu M,Zaharie T,Rusu I,Pojoga C,Bolboacă SD,Seicean R,Petrusel L,Seicean A

    更新日期:2020-11-21 00:00:00

  • Sources of diagnostic discrepancies in fine-needle aspiration of the breast.

    abstract::Fine-needle aspiration (FNA) is a valuable technique to use in the evaluation of breast lesions; however, inadequate and discrepant diagnoses do occur. To identify the source and nature of inaccuracies related to the method we studied 39 cases in which FNA posed diagnostic problems. These problems could be attributed ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Scopa CD,Koukouras D,Androulakis J,Bonikos D

    更新日期:1991-01-01 00:00:00

  • Cytology of embryonal rhabdomyosarcoma: a cytologic, light microscopic, electron microscopic, and immunohistochemical study of seven cases.

    abstract::A correlated cytologic and histologic study of seven cases of embryonal rhabdomyosarcoma is presented. The diagnosis of rhabdomyosarcoma was established by light and electron microscopy and immunohistochemistry of the operative specimens. The cytologic appearance of the smears corresponded well with the histopathologi...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Seidal T,Walaas L,Kindblom LG,Angervall L

    更新日期:1988-01-01 00:00:00

  • Aluminum silicate-containing psammoma bodies in a cervicovaginal smear (Pap): cytological, ultrastructural, and radiographic microprobe studies.

    abstract::Psammoma body is a rare finding in a cervicovaginal smear and can be associated with either benign or malignant diseases. Here we report a case to illustrate the association of psammoma bodies with benign granulomatous reactions to a foreign material (aluminum silicate). ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Li S,Boudousquie AC,Baloch ZW,Minda JM,Gupta PK

    更新日期:1999-08-01 00:00:00

  • Cytological typing of primary lung cancer: study of 100 cases with autopsy confirmation.

    abstract::In order to assess the accuracy of bronchial aspiration cytology in typing lung cancer, tissue sections from 100 autopsy cases of lung cancer were compared with the cytology features observed in the same patients prior to death. There was 100% accuracy in the cytology of small-cell carcinoma; 90% in squamous-cell carc...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: DiBonito L,Colautti I,Patriarca S,Falconieri G,Barbazza R,Vielh P

    更新日期:1991-01-01 00:00:00

  • Pitfalls in the cytological diagnosis of tenosynovial giant cell tumor: An illustration of eight discordant cases.

    abstract::Tenosynovial giant cell tumor (TSGCT) is a highly recurrent benign tumor of the extremities. Wide local excision is usually sufficient to achieve its recurrence-free outcome. However, that needs a confident pre-operative cytological diagnosis as TSGCT. Aspirates from this tumor express the characteristic polymorphic c...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Mondal K,Mandal R,Khan K,Chakraborty J

    更新日期:2018-03-01 00:00:00

  • Cytologic diagnosis of true thymic hyperplasia by combined radiologic imaging and aspiration cytology: a case report including flow cytometric analysis.

    abstract::True thymic hyperplasia (TH) is an age-dependent increase in size and weight of the thymus gland, which by definition maintains a normal histologic architecture. TH can mimic other important diseases, including lymphofollicular hyperplasia, thymoma, lymphoma, and germ-cell tumors. Traditionally, separating these entit...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Hoerl HD,Wojtowycz M,Gallagher HA,Kurtycz DF

    更新日期:2000-12-01 00:00:00

  • Fine-needle aspiration cytology of breast: its impact on surgical practice with an emphasis on the diagnosis of breast abnormalities in young women.

    abstract::Fine-needle aspiration cytology (FNAC) of the breast is a minimally invasive yet maximally diagnostic method, often precluding the need of an open biopsy. In young women, in whom breast cancer is a rare disorder, it is also important that carcinoma is recognized without delay so that an appropriate plan of management ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: Gupta RK,Naran S,Buchanan A,Fauck R,Simpson J

    更新日期:1988-01-01 00:00:00

  • Prognostic value of breast cancer cytologic grading: a retrospective study of 213 cases.

    abstract::The authors evaluate 213 consecutive breast cancer cases with positive fine-needle aspiration cytology. Cytologic smears were reviewed and classified according to a grading system. A correlation between cytologic grading and pathological stage (T and N category) was observed. Univariate analysis of 5-yr overall surviv...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Ciatto S,Bonardi R,Herd-Smith A,Cariaggi P,Confortini M,Bulgaresi P

    更新日期:1993-01-01 00:00:00

  • A prospective study of the diagnostic accuracy of cytological criteria in the FNAB diagnosis of breast papillomas.

    abstract::Seventy-four fine needle aspiration biopsies (FNAB) of breast were selected from the 133 cases with surgical biopsy follow up, from a total of 1,154 consecutive breast FNAB received in a 6-month-period. These 74 cases were reviewed and scored using all relevant cytological criteria for proliferative breast lesions use...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Field A,Mak A

    更新日期:2007-08-01 00:00:00

  • Pancreatic adenocarcinoma: regression analysis to identify improved cytologic criteria.

    abstract::The incidence of pancreatic adenocarcinoma is increasing and it is usually unresectable at the time of diagnosis. Consequently, fine-needle aspiration biopsy (FNAB) is being used more frequently for diagnosis. The reported sensitivity of diagnosing pancreatic adenocarcinoma by FNAB has varied between 50% and 100%. In ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Cohen MB,Egerter DP,Holly EA,Ahn DK,Miller TR

    更新日期:1991-01-01 00:00:00

  • Bladder-washing cytology of metastatic ovarian granulosa cell tumor.

    abstract::An 86-year-old Caucasian female presented with two weeks history of discomfort discharging urine, occasional hematuria, and suprapubic pain. The patient had a history of left salpingo-oophorectomy for an ovarian tumor, performed four years earlier. Ultrasound showed a solid mass surrounding the orifice of the left ure...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Vodovnik A

    更新日期:2002-06-01 00:00:00

  • Fine-needle aspiration cytomorphology of sebaceous lymphadenoma of the salivary gland.

    abstract::Sebaceous lymphadenoma (SLA) is a histologic variant of lymphadenoma or sebaceous adenoma of the salivary gland. The fine-needle aspiration (FNA) cytology of SLA has not been well-described. In this report, we reported a case that involved an 81-year-old male with a long-standing left parotid mass and was diagnosed on...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Vande Haar MA,DeFrias D,Lin X

    更新日期:2014-11-01 00:00:00

  • Papanicolaou's nebular cells are related to HPV infection and HSIL.

    abstract::Metaplastic cells with nebular cytoplasmic changes in the cervical smear are classified in the Dutch coding system for cervical screening as KOPAC O8 cells. Since these nebulated cells are already documented by Papanicolaou, we refer to these cells as Papanicolaou's nebular cells. We examined the simultaneous presence...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Roeters AM,Boon ME,van Haaften M,Vernooij F,Bontekoe TR,Heintz AP

    更新日期:2012-03-01 00:00:00

  • Progression of cervical lesions in HIV-seropositive women: a cytological study.

    abstract::It has been reported that cervical intraepithelial lesions have a more aggressive course in HIV-seropositive than in HIV-seronegative women. In the present investigation, the progression of these cervical lesions was studied in a group of HIV-seropositive women. Of 1,587 patients, 200 (12.6%) had a cytological diagnos...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Calore EE,Pereira SM,Cavaliere MJ

    更新日期:2001-02-01 00:00:00

  • Lipoblastoma presenting as a rapidly growing paravertebral mass and masquerading as myxoid liposarcoma on fine needle aspiration cytology.

    abstract::Lipoblastoma is a peculiar variant of lipoma occurring almost exclusively during infancy and early childhood. It is found most commonly in the upper and lower extremities; less common sites are head and neck, trunk, mediastinum, and retroperitoneum. It has a greater predilection for boys and commonly presents as a slo...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Kalaivani Selvi S,Pradhan P,Rajesh NG,Gochhait D,Barwad A

    更新日期:2016-05-01 00:00:00

  • Fine-needle aspiration as the initial diagnostic modality in malignant lung disease.

    abstract::Cytologic detection of lung cancer is accepted, accurate, and time-honored. Typically, cytologic workup of a radiologic abnormality proceeds sequentially from sputum to bronchoalveolar cytology, and, if necessary, to fine-needle aspiration biopsy (FNA). Initial use of FNA in lung cancer diagnosis is controversial, but...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Blumenfeld W,Singer M,Glanz S,Hon M

    更新日期:1996-05-01 00:00:00

  • Cytology of sclerosing epithelioid fibrosarcoma in pleural effusion.

    abstract::We report a case of sclerosing epithelioid fibrosarcoma focusing on its cytological features in pleural effusion. A 32-year-old man had noticed a tumor in his left buttock 5 years earlier but had not sought treatment because the tumor had been painless. He visited our hospital because the tumor had gradually increased...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Tsuchido K,Yamada M,Satou T,Otsuki Y,Shimizu S,Kobayashi H

    更新日期:2010-10-01 00:00:00

  • Diagnostic value of AgNOR method in thyroid cytopathology: correlation with morphometric measurements.

    abstract::A silver staining technique was applied to 51 thyroid smears. The numbers of silver-stained nucleolar organizer regions (AgNORs) were counted, and the mean AgNOR and nuclear area per cell were determined with an image analyzer. The mean AgNOR count per cell was significantly higher in malignant than in benign lesions,...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Solymosi T,Tóth V,Sápi Z,Bodó M,Gál I,Csanádi L

    更新日期:1996-03-01 00:00:00

  • Cytomorphologic features of small cell carcinoma of lung in effusion fluid using a liquid-based cytology technique.

    abstract:BACKGROUND:Liquid-based cytology (LBC) testing induces morphologic changes due to the use of specific fixatives and preparation techniques, and the cytologies of effusions determined in this manner differ morphologically from those of conventional cytopreparation (CCP) smear methods. We compared the cytologic features ...

    journal_title:Diagnostic cytopathology

    pub_type: 临床试验,杂志文章


    authors: Kim L,Choi SJ,Park IS,Han JY,Kim JM,Chu YC

    更新日期:2020-03-01 00:00:00

  • Cytological features of warthin-like papillary thyroid carcinoma: A case report with review of previous cytology cases.

    abstract::Warthin-like papillary thyroid carcinoma (WLPTC) is a rare morphological variant of papillary thyroid carcinoma which mimics various benign and malignant lesions on thyroid aspiration cytology. As correct cytological diagnosis is the cornerstone for appropriate patient management, awareness of the salient cytomorpholo...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: Vallonthaiel AG,Agarwal S,Jain D,Yadav R,Damle NA

    更新日期:2017-09-01 00:00:00

  • Sensitivity of fine-needle aspiration for papillary carcinoma of the thyroid correlates with tumor size.

    abstract::Fine-needle aspiration (FNA) of the thyroid for papillary carcinomas is highly sensitive. We sought to determine if the sensitivity of FNA for papillary carcinoma is correlated with the size of the tumor. We reviewed the results of thyroid resections for the last 12 years and correlated the findings with clinical and ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Renshaw AA

    更新日期:2011-07-01 00:00:00