Immunocytochemical typification of mesothelial cells in effusions: in vivo and in vitro models.

Abstract:

:We have performed immunocytochemical, immunoelectron microscopy, Western blot, and culture techniques using monoclonal antibodies against cytokeratin, vimentin, and desmin on 17 benign and 20 malignant effusions of pleural and ascitic origin. Triple coexpression of these three antigens was observed in benign reactive mesothelial cells as well as in one case of mesothelioma. All metastatic adenocarcinoma cells were consistently negative to desmin and positive to cytokeratin and vimentin. Present results were helpful to distinguish reactive and malignant mesothelioma from metastatic carcinoma cells in effusions.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Ferrandez-Izquierdo A,Navarro-Fos S,Gonzalez-Devesa M,Gil-Benso R,Llombart-Bosch A

doi

10.1002/dc.2840100313

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

256-62

issue

3

eissn

8755-1039

issn

1097-0339

journal_volume

10

pub_type

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