Diagnosis of hairy cell leukaemia by fine needle aspiration cytology of lymph node.

Abstract:

BACKGROUND:Hairy cell leukaemia (HCL) is a rare lymphoproliferative disorder of B cell origin, and uncommonly it affects the lymph node. Fine needle aspiration cytology (FNAC) of lymph node of HCL has rarely been described. CASE DESCRIPTION AND DIAGNOSIS:A 41-year-old man presented with pallor, fever, tachycardia, generalized lymphadenopathy, and massive splenomegaly. The FNAC of the cervical lymph node was done. The smears showed many atypical lymphocytes with a plasmacytoid appearance. There were many large cells with round to reniform shaped nuclei having with hair-like cytoplasmic processes. Flow cytometry (FCM) revealed a clonal B cell population with light chain restriction and positive CD20, CD79b, CD22, CD11c, CD25, CD103, CD123, and CD200 markers. CONCLUSION:The characteristic cytological features such as atypical lymphoid cells, large cells with hairy projections along with FCM findings, are helpful in the diagnosis of HCL.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Suneel R,Rajasekaran S,Kaur H,Mallik N,Garg D,Jain A,Dey P

doi

10.1002/dc.24627

subject

Has Abstract

pub_date

2020-10-01 00:00:00

eissn

8755-1039

issn

1097-0339

pub_type

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