Abstract:
:Juvenile xanthogranuloma (JXG) is a rare lesion of the skin and deep tissues whose cytologic features have not previously been published. We report on 2 cases of JXG in patients aged 5 days and 5 yr who presented with an axillary mass and enlarged supraclavicular lymph node, respectively. Fine-needle aspiration and touch imprints made from the surgical biopsies yielded cellular specimens composed of histiocytes, multinucleated Touton-type giant cells, and variable admixtures of lymphocytes and eosinophils. One lesion was composed primarily of benign-appearing histiocytes with admixed multinucleated giant cells and a few lymphocytes. The second lesion consisted of a few histiocytes, occasional Touton giant cells, many lymphocytes, and scattered fibroblasts. The histiocytes were CD68-positive and S100-negative. Histologic follow-up confirmed the diagnosis of juvenile xanthogranuloma. One patient was lost to follow-up; the other is alive without evidence of recurrence 1 yr after surgery. We conclude that deep JXG has characteristic and diagnostic cytologic features.
journal_name
Diagn Cytopatholjournal_title
Diagnostic cytopathologyauthors
Grenko RT,Sickel JZ,Abendroth CS,Cilley REdoi
10.1002/(SICI)1097-0339(199611)15:4<329::AID-DC15>subject
Has Abstractpub_date
1996-11-01 00:00:00pages
329-33issue
4eissn
8755-1039issn
1097-0339pii
10.1002/(SICI)1097-0339(199611)15:4<329::AID-DC15>journal_volume
15pub_type
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