Utility of CD138 (syndecan-1) in distinguishing carcinomas from mesotheliomas.


:CD138 (Syndecan-1) is a transmembrane heparan sulfate proteoglycan present on the surface of plasma cells and epithelial cells. CD138 is also expressed in some hematopoietic neoplasms and has recently been observed in carcinomas. We characterized CD138 expression in cell-block preparations of fluids/effusions, focusing on the distinction between carcinoma and mesothelioma. One hundred formalin-fixed, paraffin-embedded cell-block sections of fluids/effusions consisting of 58 metastatic carcinomas, 24 mesotheliomas, 11 reactive mesothelial cell proliferations, 3 lymphomas, 3 metastatic sarcomas, and 1 metastatic melanoma were stained with a monoclonal antibody against CD138. CD138 staining was observed in 32/58 (55%) metastatic carcinomas and 2/24 (8%) mesotheliomas; all reactive mesothelial cells, lymphomas, sarcomas, and melanoma were negative. CD138 is a highly specific marker in the differential diagnosis of carcinoma vs. mesothelioma. Distinct membranous staining without background staining of most inflammatory cells makes CD138 an ideal marker for cell-block preparations of fluids/effusions. It should be an integral component of the epithelial-mesothelial antibody panel.


Diagn Cytopathol


Diagnostic cytopathology


Saqi A,Yun SS,Yu GH,Alexis D,Taub RN,Powell CA,Borczuk AC




Has Abstract


2005-08-01 00:00:00












  • Flow cytometric S-phase fraction as a complementary biological parameter for the cytological grading of non-Hodgkin's lymphoma.

    abstract::Fine-needle aspiration cytology (FNAC) is a technique that can overcome tissue-sampling disaggregation problems related to DNA flow cytometry analysis. The aim of this study, with long-term follow-up (median, 72 mo), was to investigate the prognostic value of DNA ploidy and S-phase fraction (SPF) in patients with non-...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Pinto AE,Cabeçadas J,Nóbrega SD,Mendonça E

    更新日期:2003-10-01 00:00:00

  • Cytological features of warthin-like papillary thyroid carcinoma: A case report with review of previous cytology cases.

    abstract::Warthin-like papillary thyroid carcinoma (WLPTC) is a rare morphological variant of papillary thyroid carcinoma which mimics various benign and malignant lesions on thyroid aspiration cytology. As correct cytological diagnosis is the cornerstone for appropriate patient management, awareness of the salient cytomorpholo...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: Vallonthaiel AG,Agarwal S,Jain D,Yadav R,Damle NA

    更新日期:2017-09-01 00:00:00

  • Metastatic pheochromocytoma to the pancreas diagnosed by endoscopic ultrasound-guided fine needle aspiration: A case report and review of literature.

    abstract::Pancreatic pheochromocytomas are rare and typically diagnosed by local resection. We present the first reported case of metastatic pheochromocytoma to the pancreas diagnosed by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and cytology. A 67-year-old female presented with 2 to 3 months of abdominal pai...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: Yang SX,Dogra VS,Kothari TH,Reyes MCD

    更新日期:2020-03-01 00:00:00

  • Pericardial effusion as primary manifestation of metastatic cutaneous adenoid cystic carcinoma: diagnostic cytopathology from an exfoliative sample.

    abstract::Adenoid cystic carcinoma (ACC) occurs not only as a tumor of salivary glands, but also in very unusual locations, such as in the skin. Only very few cases of primary cutaneous of ACC have metastasized to the lymph nodes and lungs. We present a 53-year-old man with metastasis of the pericardium from a primary cutaneous...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Benchetritt M,Butori C,Long E,Ilie M,Ferrari E,Hofman P

    更新日期:2008-05-01 00:00:00

  • Reproducibility of atypia of undetermined significance/follicular lesion of undetermined significance category using the bethesda system for reporting thyroid cytology when reviewing slides from different institutions: A study of interobserver variability

    abstract:BACKGROUND:The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) offers a six-tiered diagnostic scheme for thyroid Fine Needle Aspiration (FNA): Benign, Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance (AUS/FLUS), suspicious for follicular neoplasm, suspicious for malignancy...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Padmanabhan V,Marshall CB,Akdas Barkan G,Ghofrani M,Laser A,Tolgay Ocal I,David Sturgis C,Souers R,Kurtycz DF

    更新日期:2017-05-01 00:00:00

  • Diagnostic value of fine-needle aspiration in supraclavicular lymphadenopathy: a study of 106 patients and review of literature.

    abstract::The simplicity and safety of the fine-needle aspiration (FNA) make it a useful procedure for the initial evaluation of supraclavicular lymphadenopathy. We analyzed data (106 patients) in combination with the data of three recently published studies (total 301 patients) to make the observations more meaningful. The use...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: Nasuti JF,Mehrotra R,Gupta PK

    更新日期:2001-12-01 00:00:00

  • Can glandular lesions be diagnosed in pap smear cytology?

    abstract::Many reports have been published on the accuracy of the cervical vaginal smear for squamous lesions, and the literature contains fewer reports on the accuracy of the cervical vaginal smear for glandular lesions. The sensitivity of glandular lesion diagnosis depends on the subtype of lesion. The diagnostic sensitivity ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: Raab SS

    更新日期:2000-08-01 00:00:00

  • Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): diagnosis with fine-needle aspiration in a case with nodal and nasal involvement.

    abstract::Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare entity characterized by the proliferation of cells belonging to the macrophage-histiocyte family, but whose exact origin is unknown. A case of SHML occurring in a 62-yr-old female is described in which the diagnosis is initially suggested by fine-needle...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Alvarez Alegret R,Martinez Tello A,Ramirez T,Gállego P,Martinez D,García Julían G

    更新日期:1995-11-01 00:00:00

  • Cytomorphologic manifestations of Alzheimer's disease using brain squash smears: an autopsy study with histology-cytology correlation.

    abstract::Alzheimer's disease (AD) is the most common form of dementia. The cardinal histopathologic features include senile plaques (SPs) and neurofibrillary tangles (NFTs), and in addition, granulovacuolar degeneration (GVD) and Hirano bodies (HBs) are frequently observed in the hippocampus. We studied hippocampal cytological...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Takei H,Kosarac O,Powell SZ

    更新日期:2009-09-01 00:00:00

  • Fine-needle aspiration cytology of non-small cell lung carcinoma: A paradigm shift.

    abstract::Lung carcinoma is one of the commonest causes of cancer related death. Fine-needle aspiration cytology (FNAC) is a well-established technique in the diagnosis of various malignant tumors. FNAC is now an important technique in classifying lung carcinomas and also detecting salient mutational changes in lung carcinomas....

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审


    authors: Dey P,Ghosh RK

    更新日期:2019-04-01 00:00:00

  • Enhancing the scope of conventional cervical cytology for detecting HPV infection.

    abstract::Cervical neoplasia is attributed to a persistent Human Papilloma Virus infection. The Pap smear being the mainstay of cervical cancer screening in low-resource settings, we studied the nonclassical features which might indicate HPV infection. These included abortive koilocytes, mild dyskeratosis, parakeratosis, mild n...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Nijhawan R,Mittal N,Suri V,Rajwanshi A

    更新日期:2010-09-01 00:00:00

  • Autofluorescence--an important ancillary technique for the detection of Mycobacterium tuberculosis: revisited.

    abstract::Tuberculosis is one of the oldest diseases known to affect humans and is caused by Mycobacterium tuberculosis. Lymph nodes are the most common site of extrapulmonary involvement. Tuberculous lymphadenitis can be presumptively diagnosed morphologically on fine-needle aspiration biopsy of lymph nodes. Additional tests l...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Joshi P,Singh M,Bhargava A,Singh M,Mehrotra R

    更新日期:2013-04-01 00:00:00

  • Cytologic features of sebaceous, lymphadenoma, and sebaceous lymphadenocarcinoma: Differential diagnostic considerations.

    abstract:BACKGROUND:Sebaceous lymphadenomas and sebaceous lymphadenocarcinomas are uncommon neoplasms occurring predominately within the parotid gland. Cytomorphology of these neoplasms is rarely reported. Occasional reports have discussed the cytomorphological features of these neoplasms but criteria distinguishing sebaceous l...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Vazmitsel M,Esebua M,Layfield LJ

    更新日期:2020-05-01 00:00:00

  • Are adjunctive markers useful in routine cervical cancer screening? Application of p16(INK4a) and HPV-PCR on ThinPrep samples with histological follow-up.

    abstract::The objectives of the study were to evaluate 1) the diagnostic sensitivity and specificity of p16(INK4a) as a marker for high-grade cervical lesions, 2) the results of a real-time polymerase chain reaction detecting high-risk human papillomavirus, and 3) the interobserver variability of the p16(INK4a) interpretation.A...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Schledermann D,Andersen BT,Bisgaard K,Dohse M,Ejersbo D,Hoelund B,Horal P,Lindh M,Ryd W

    更新日期:2008-07-01 00:00:00

  • Diagnostic accuracy of molecular testing with three molecular markers on thyroid fine-needle aspiration cytology with abnormal category.

    abstract:BACKGROUND:Cases with abnormal category, determined by thyroid fine-needle aspiration (FNA), frequently undergo surgical resection, despite the majority of cases being identified as benign after resection. Additional diagnostic markers are needed to guide the management of patients with abnormal thyroid nodules. MATER...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Seneldir H,Kir G,Soylemez T,Girgin RB,Ozbay N,Ozen F,Ankarali H,Bas G,Alimoglu O

    更新日期:2020-06-01 00:00:00

  • Urinary tract washing specimens containing atypical urothelial tissue fragments are significantly associated with urothelial neoplasia.

    abstract:BACKGROUND:We previously found that the presence of atypical urothelial tissue fragments (AUTF) was associated with an increased risk of high-grade urothelial carcinoma (HGUC) but not low-grade urothelial neoplasia (LGUN) in voided urine (VU) specimens. However, we subsequently found that patients with LGUN were more l...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Zhang ML,Zhou AG,Rosenthal DL,VandenBussche CJ

    更新日期:2017-09-01 00:00:00

  • Cytology, flow cytometry, image analysis, and interphase cytogenetics by fluorescence in situ hybridization in the diagnosis of transitional cell carcinoma in bladder washes: a comparative study.

    abstract::The diagnosis of transitional cell carcinoma (TCC) in bladder washes is a diagnostic challenge to cytology. This study assessed the role of flow cytometry (FCM), image analysis (IA), and interphase cytogenetics by fluorescence in situ hybridization (FISH) as adjuncts in the cytodiagnosis of TCC in bladder washes. Fort...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Cajulis RS,Haines GK 3rd,Frias-Hidvegi D,McVary K,Bacus JW

    更新日期:1995-10-01 00:00:00

  • Optimization of the peritoneal lavage.

    abstract::Review of 275 consecutive peritoneal lavages and concurrent histologic material from gynecologic operations suggested that cytologic evaluation was clinically indicated for only 60.7% of the lavages, representing 46% of the patients in the study. More than one concurrent lavage was received from 21.6% of all patients ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Walts AE

    更新日期:1998-04-01 00:00:00

  • Telecytology: Is it possible with smartphone images?

    abstract:INTRODUCTION:This study aimed to discuss smartphone usage in telecytology and determine intraobserver concordance between microscopic cytopathological diagnoses and diagnoses derived via static smartphone images. METHODS:The study was conducted with 172 cytologic material. A pathologist captured static images of the c...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Sahin D,Hacisalihoglu UP,Kirimlioglu SH

    更新日期:2018-01-01 00:00:00

  • A follow-up study on thyroid aspirates reported as atypia of undetermined significance/follicular lesion of undetermined significance and follicular neoplasm/suspicious for follicular neoplasm: A multicenter study from the Arabian Gulf region.

    abstract:OBJECTIVE:This is a multicenter study which was conducted to evaluate the follow-up on thyroid aspirate cases with atypia of undetermined significance/follicular cells of undetermined significance (AUS/FLUS) and follicular neoplasm or suspicious for follicular neoplasm (FN/SFN) using the Bethesda system for reporting t...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,多中心研究


    authors: Al-Abbadi MA,Shareef SQ,Yousef MM,Almasri NM,Mustafa HE,Aljawad H,Ali JA,Groves A,Alsaihati Y

    更新日期:2017-11-01 00:00:00

  • Cytologic features of sclerosing hemangioma of the lung on crush preparations.

    abstract::Sclerosing hemangioma of the lung is a rare benign neoplasm. The majority of the literature published on sclerosing hemangioma has focused on the histologic features, while only a few case reports have described the cytologic features. We report two additional cases of sclerosing hemangioma of the lung in which the cy...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Blanco LZ,Heagley DE,Montebelli F,Gabrielli E,Reddy V,Ghai R,Gattuso P

    更新日期:2013-03-01 00:00:00

  • The 1988 Bethesda System for reporting cervical/vaginal cytologic diagnoses: developed and approved at the National Cancer Institute workshop in Bethesda, MD, December 12-13, 1988.

    abstract::The Bethesda System for reporting cervical/vaginal diagnoses, introduced in this article, is a flexible guideline and can be modified as appropriate to meet the needs of cytopathologists, referring physicians, and patients. ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章



    更新日期:1989-01-01 00:00:00

  • Epithelioid variant of gastrointestinal stromal tumor: Diagnosis by fine-needle aspiration.

    abstract::Epithelioid gastrointestinal stromal tumors (GISTs) may cause significant diagnostic confusion on fine-needle aspiration (FNA) with carcinomas, neuroendocrine tumors, and melanoma, particularly when metastatic. This study characterizes the cytologic features of nine cases of epithelioid GISTs that were obtained by com...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Dong Q,McKee G,Pitman M,Geisinger K,Tambouret R

    更新日期:2003-08-01 00:00:00

  • Plasmablastic lymphoma of the cecum: report of a case with cytologic findings.

    abstract::Plasmablastic lymphoma (PBL) is a rare lymphoma that is characterized by a diffuse proliferation of large neoplastic cells resembling B immunoblasts, but shows the immunophenotype of plasma cells. PBL is most commonly seen in the oral cavity of human immunodeficiency virus (HIV)-positive patients. Epstein-Barr virus (...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Hatanaka K,Nakamura N,Kishimoto K,Sugino K,Uekusa T

    更新日期:2011-04-01 00:00:00

  • Fine-needle aspiration cytology of seminoma: a review of 16 cases.

    abstract::We report the cytomorphologic features of 16 fine-needle aspiration (FNA) biopsies of seminoma obtained from 16 male patients. The aspirates included two primary gonadal tumors (one occurring in a cryptorchid testis), two primary mediastinal tumors, and 12 metastases (two with unknown primaries). Analysis of the aspir...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Caraway NP,Fanning CV,Amato RJ,Sneige N

    更新日期:1995-06-01 00:00:00

  • Hyaluronic acid induced foreign body reaction mimicking neoplastic parotid cytology.

    abstract::Masses near the angle of the mandible containing extracellular matrix or mucin on cytology raise concern for various benign and malignant parotid gland neoplasms. Here a 76-year-old female with a history of cosmetic hyaluronic acid (HA) filler injections presented with a painless 6 mm left sided facial mass. Injection...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Davis A,Basu D,Suyash M,Jalaly JB

    更新日期:2019-09-01 00:00:00

  • Bleeding from Wharton's duct after fine-needle aspiration biopsy on submandibular gland.

    abstract::The case of a fine-needle aspiration biopsy (FNAB) of the patient's salivary gland lesions is considered a rapid, simple, reliable, minimal invasive procedure with markedly rare complications. Herein, we report a case of bleeding from the region of the Wharton's duct after a procedure of a FNAB on the patient's subman...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Lee DH,Yoon TM,Lee JK,Lim SC

    更新日期:2018-11-01 00:00:00

  • Parathyroid hormone assay in fine-needle aspirate is useful in differentiating inadvertently sampled parathyroid tissue from thyroid lesions.

    abstract::To assess the utility of chemical analysis for parathyroid hormone in the rinse (PTH-r) obtained via fine-needle aspiration (FNA) in the setting of inadvertently sampled parathyroid tissue or lesions (PTL) during "thyroid" or "neck" FNA, the authors review their experience at a large, tertiary care academic medical ce...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Owens CL,Rekhtman N,Sokoll L,Ali SZ

    更新日期:2008-04-01 00:00:00

  • A prospective study of the diagnostic accuracy of cytological criteria in the FNAB diagnosis of breast papillomas.

    abstract::Seventy-four fine needle aspiration biopsies (FNAB) of breast were selected from the 133 cases with surgical biopsy follow up, from a total of 1,154 consecutive breast FNAB received in a 6-month-period. These 74 cases were reviewed and scored using all relevant cytological criteria for proliferative breast lesions use...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Field A,Mak A

    更新日期:2007-08-01 00:00:00

  • Improving ROSE: Discrepant touch preparation and histology findings in cytology of renal masses: A 10-year retrospective review.

    abstract:BACKGROUND:The number of "renal incidentalomas" is on the rise due to increasing use of radiologic studies. Image-guided core needle biopsies (CNB) with touch preparations are performed to guide specimen collection and triage of sample for additional studies. Results allow the clinical team to make appropriate treatmen...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章


    authors: Shachner TR,Nodit L,Hubbard E,Van Meter S

    更新日期:2019-10-01 00:00:00