Papillary thyroid carcinoma with an adenoid cystic pattern: report of a case with fine-needle aspiration cytology and immunocytochemistry.

Abstract:

:Although fine-needle aspiration (FNA) cytologic features of conventional papillary thyroid carcinoma (PTC) and some of its variants have been documented in the literature, PTC with an adenoid cystic pattern has not so far been described. A 35-year-old woman presented with solitary cold nodule in the right lobe of thyroid. FNA smears from the nodule showed features of PTC such as papilliform clusters, monolayered sheets, psammoma bodies, increased frequency of nuclear grooves, and intranuclear cytoplasmic inclusions. In addition, there were areas of follicular formation and light-pink to deep-purple hyaline globules with a laminated appearance and surrounded by neoplastic cells, reminiscent of adenoid cystic carcinoma. These globules were present in 53% of the follicles. Immunocytochemical staining for thyroglobulin yielded positive cytoplasmic reaction in the neoplastic cells. Histopathology of the thyroidectomy specimen confirmed the cytodiagnosis of PTC. The hyaline globules were present focally and were light pink to deep purple with a laminated appearance resembling psamomma bodies. The colloid and follicular cells were positive for thyroglobulin but the hyaline globules were negative. Von Kossa staining for calcium revealed positive reaction in the psamomma bodies and some of the hyaline globules, indicating that the globules may be the beginning of psammoma bodies. Thus, FNA cytology was useful in diagnosing an unusual variant of PTC.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Haji BE,Ahmed MS,Prasad A,Omar MS,Das DK

doi

10.1002/dc.20063

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

418-21

issue

6

eissn

8755-1039

issn

1097-0339

journal_volume

30

pub_type

杂志文章
  • Lymphoepithelial cyst (LEC) of the pancreas: cytomorphology and differential diagnosis on fine-needle aspiration (FNA).

    abstract::Lymphoepithelial cyst (LEC) of the pancreas is an extremely rare benign entity. We describe the cytopathologic findings of such a lesion in a 49-yr-old woman who was examined for epigastric pain. A trans-esophageal ultrasound-guided fine-needle aspiration of a pancreatic mass disclosed an intimate mixture of squamous ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199906)20:6<371::aid-dc8>3

    authors: Mandavilli SR,Port J,Ali SZ

    更新日期:1999-06-01 00:00:00

  • Radiation-induced changes in the breast: a potential diagnostic pitfall on fine-needle aspiration.

    abstract::The authors report a case of fine-needle aspiration (FNA) of a breast mass in a 36-year-old woman with previous history of lumpectomy and therapeutic radiation for breast carcinoma. The changes seen were interpreted as recurrent carcinoma, while subsequent biopsy showed only radiation changes. Radiation-induced change...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840080117

    authors: Dornfeld JM,Thompson SK,Shurbaji MS

    更新日期:1992-01-01 00:00:00

  • Logistic regression analysis of myxoid sarcomas: a cytologic study.

    abstract::The objective of this study was to identify key diagnostic cytologic criteria for the most common myxoid sarcomas studied by fine-needle aspiration cytology. We reviewed 27 myxoid malignant fibrous histiocytomas, 8 chordomas, 16 chondrosarcomas, and 12 myxoid liposarcomas in which both cytologic specimens and final hi...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199811)19:5<355::aid-dc9>3

    authors: Layfield LJ,Liu K,Dodge RK

    更新日期:1998-11-01 00:00:00

  • Imprint cytology of strumal carcinoid of the ovary: A case report with immunocytochemical analysis.

    abstract::Strumal carcinoid is a rare ovarian tumor defined as carcinoid associated with struma ovarii. We report here the second cytological case of strumal carcinoid and performed immunocytochemical analysis for the first time. A 68-year-old Japanese female was found to have a solid tumor with small cystic components in the l...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24042

    authors: Ishida M,Arimoto T,Sandoh K,Okano K,Ebisu Y,Ito H,Matsumoto M,Mizokami T,Kita M,Okada H,Tsuta K

    更新日期:2019-03-01 00:00:00

  • Pilomyxoid astrocytoma of the pineal region: cytopathological features and differential diagnostic considerations by intraoperative smear preparation.

    abstract::Pilomyxoid astrocytoma (PMA) is a recently identified type of pilocytic astrocytoma (PA) with shorter progression-free and overall survival, higher rate of recurrence, and higher risk of leptomeningeal spread compared to pilocytic tumors (WHO grade 2 designation). A case is presented here in which intraoperative impri...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23133

    authors: Hayashi T,Haba R,Kushida Y,Katsuki N,Shibuya S,Kadota K,Matsunaga T,Miyake K,Tamiya T

    更新日期:2015-02-01 00:00:00

  • Motile ciliary microorganisms in peritoneal fluid.

    abstract::We report a patient with chronic renal failure and ciliocytophthoria or "detached ciliary tufts" identified from her peritoneal fluid. The recognition of these rare structures is critical to avoid misdiagnosing a presumed protozoan infection and embarking on further costly investigations and unnecessary treatments. ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21505

    authors: Vila M,Thompson K,Erdem G

    更新日期:2011-08-01 00:00:00

  • The diagnostic utility of cell block in fine needle aspiration cytology of palpable breast lesions in a Nigerian tertiary health institution.

    abstract:BACKGROUND:Although fine needle aspiration cytology (FNAC) is highly accurate for detecting breast malignancies, concerns remain among cytopathologists about false-positive and false-negative diagnoses. Cell block (CB) preparations have been advocated by some cytopathologists as one of the methods to improve and consol...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24576

    authors: Obiajulu FJN,Daramola AO,Anunobi CC,Ikeri NZ,Abdulkareem FB,Banjo AA

    更新日期:2020-12-01 00:00:00

  • Localized primary amyloid tumor associated with osseous metaplasia presenting as bilateral breast masses: cytologic and radiologic features.

    abstract::This report details the cytologic features of primary localized amyloid tumor of the breast presenting as bilateral breast masses in a 72-yr-old woman. Clinically and radiographically, the masses simulated metastatic or multifocal carcinoma. Fine-needle aspiration revealed irregular globules of acellular amorphous mat...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840090521

    authors: Lynch LA,Moriarty AT

    更新日期:1993-10-01 00:00:00

  • Aspiration cytology of neuroblastoma: light microscopy with transmission and scanning electron microscopic correlations.

    abstract::Fine-needle aspiration biopsies from three patients with neuroblastoma were studied by light microscopy, and the morphologic findings were correlated with those from transmission and scanning electron microscopy. Light microscopic examination of the aspiration smears from all three cases revealed small and large round...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840040410

    authors: Akhtar M,Ali MA,Sackey K,Sabbah R,Bakry M

    更新日期:1988-01-01 00:00:00

  • Paragonimiasis in a cystic breast mass: case report and implications for examination of aspirated cyst fluids.

    abstract::We report a case of paragonimiasis diagnosed by fine-needle aspiration of a breast mass in a middle-aged Korean female with a history of breast silicone injections. Although parasitoses have been discovered by aspiration of cyst fluid in otherwise sterile sites (i.e., liver and lung), the cystic presentation in the br...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840100308

    authors: Fogel SP,Chandrasoma PT

    更新日期:1994-01-01 00:00:00

  • Parathyroid fine-needle aspiration cytology in the evaluation of parathyroid adenoma: cytologic findings from 53 patients.

    abstract::This study was designed to assess the utility of fine-needle aspiration cytology (FNAC) in the preoperative localization of parathyroid adenoma (PA). Fifty-seven samples from fifty-three cases of PA (four patients had bilateral disease) were obtained by ultrasound (US)-guided fine-needle aspiration. Parathyroid hormon...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21020

    authors: Agarwal AM,Bentz JS,Hungerford R,Abraham D

    更新日期:2009-06-01 00:00:00

  • Epithelioid cell granulomas in urine cytology smears: Same cause, different implications.

    abstract::Tuberculosis of the urinary tract is usually secondary to tuberculosis of the kidney. Multinucleated giant cell histiocytes, often with peripheral nuclei (Langhans' cells), may be identified. Acid-fast bacilli on smear or positive urine cultures confirm the diagnosis. Similar findings can also be seen in patients trea...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21327

    authors: Arora SK,Gupta N,Nijhawan R,Mandal AK

    更新日期:2010-10-01 00:00:00

  • Progression of cervical lesions in HIV-seropositive women: a cytological study.

    abstract::It has been reported that cervical intraepithelial lesions have a more aggressive course in HIV-seropositive than in HIV-seronegative women. In the present investigation, the progression of these cervical lesions was studied in a group of HIV-seropositive women. Of 1,587 patients, 200 (12.6%) had a cytological diagnos...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/1097-0339(200102)24:2<117::aid-dc1021>3.0.

    authors: Calore EE,Pereira SM,Cavaliere MJ

    更新日期:2001-02-01 00:00:00

  • Signet-ring lymphoma: report of a case.

    abstract::Signet-ring lymphoma is a rare entity in which the synthesis or secretion of immunoglobulins is impaired, producing a signet-ring appearance to the lymphoma cells. A case of this type of lymphoma is described, and the cytologic aspects of the cells obtained from the fixative fluid are described. ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840020413

    authors: Manivel-Rodriguez JC,Monroy MN,Alonso-De Ruiz P,Larraza O,Orazco-Estevez H,Valenzuela Espinoza A

    更新日期:1986-12-01 00:00:00

  • Fine-needle aspiration of hepatocellular carcinoma: False-negative result due to epithelioid cells.

    abstract::The presence of epithelioid cells in fine-needle aspirations of a liver nodule is rare, but may complicate the diagnosis of the nodule. We report on a case of a liver nodule in hepatitis C cirrhosis. Results of fine-needle aspiration mainly revealed the presence of epithelioid cells, without any recognizable tumor cel...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.1087

    authors: Mourra N,Flejou JF

    更新日期:2001-06-01 00:00:00

  • Fine-catheter aspiration cytology of peritoneal cavity: a new system with potential for oncologic diagnosis.

    abstract::Fine-catheter aspiration cytology of the peritoneal cavity is a new system for obtaining a sample of peritoneal cells in the absence of fluid or the need for lavage. Its potential use in the diagnosis of peritoneal malignancy is illustrated by two case reports. ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.2840030417

    authors: Stewart RJ,Gupta RK

    更新日期:1987-12-01 00:00:00

  • PREPmate automated processor: comparison of automated and manual methods of liquid-based gynecologic sample preparation.

    abstract::The development of procedures for fully automated processing of liquid-based gynecologic samples has been the focus of considerable interest to the cytology laboratory. Liquid-based collection and processing technology has been shown to improve sample adequacy, resulting in an overall improvement in quality of sample ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.10193

    authors: Rowe LR,Marshall CJ,Bentz JS

    更新日期:2002-11-01 00:00:00

  • Distinguishing tall cell variant of papillary thyroid carcinoma from usual variant of papillary thyroid carcinoma in cytologic specimens.

    abstract::Tall cell variant (TCV) is an aggressive form of papillary thyroid carcinoma (PTC), usually associated with higher local recurrence and distant metastasis. Some authors have suggested that TCV can be effectively diagnosed on thyroid fine-needle aspiration (FNA); this diagnosis may help clinicians plan a more effective...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.10156

    authors: Solomon A,Gupta PK,LiVolsi VA,Baloch ZW

    更新日期:2002-09-01 00:00:00

  • Intraabdominal desmoplastic small round cell tumor: cytopathologic findings in two cases.

    abstract::Intraabdominal desmoplastic small round cell tumor (DSRCT) is an extremely rare entity. This study describes fine-needle aspiration, ascitic fluid, and touch imprint cytomorphology of DSRCT in 2 patients with extensive abdomino-pelvic disease. Cytopathologic features were unique and showed good morphologic correlation...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199806)18:6<449::aid-dc13>

    authors: Ali SZ,Nicol TL,Port J,Ford G

    更新日期:1998-06-01 00:00:00

  • Corpora amylacea in pleural effusion.

    abstract::Corpora amylacea are predominantly found in the brain, prostate, and lung. Recent characterizations of their components suggest an important role in protection and clearing. We report the presence of corpora amylacea in pleural effusion in a patient with lupus. The differential diagnoses and potential significance are...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24684

    authors: Mani H,Wang BG

    更新日期:2020-12-21 00:00:00

  • Fine-needle aspiration cytology with histological correlation of chordoma metastatic to the lung: a diagnostic dilemma.

    abstract::Chordoma is an uncommon tumor initially believed to be benign due to the rarity of its metastasis. Cytological, morphological, and immunohistochemical features of chordoma, relating to its origin from notochordal remnants, allows for its accurate diagnosis. A 75-year-old man with a known history of tuberculosis (TB) p...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.21548

    authors: Kanthan R,Senger JL

    更新日期:2011-12-01 00:00:00

  • Synovial sarcoma metastatic to the parotid gland: A possible pitfall in salivary gland fine needle aspiration cytology. Report of a case with immunocytochemical and fluorescence in situ hybridization findings.

    abstract::We report one case of metastatic synovial sarcoma (SS) to the parotid gland in a 93-year-old male. The patient had undergone upper left pulmonary lobectomy with mediastinal lymphadenectomy for SS of the lung 5 years before. The cytopathologic presentation and the immunocytochemical findings on the FNA sample were sugg...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.23725

    authors: Fulciniti F,Barizzi J,Martin V,Tarallo V,Ermanni S

    更新日期:2017-09-01 00:00:00

  • Epidermal growth factor receptor and Kras gene expression: reliability of mutational analysis on cytological samples.

    abstract::Epidermal growth factor receptor (EGFR) and Kras gene mutations are crucial for discriminating patients responsive to anti-EGFR drugs in non-small cell lung cancer (NSCLC) and colorectal cancer (CRC), respectively. The majority of NSCLCs come to clinical attention at an advanced stage when surgery is no longer recomme...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.22905

    authors: Bozzetti C,Negri FV,Azzoni C,Naldi N,Nizzoli R,Bortesi B,Zobbi V,Bottarelli L,Tiseo M,Silini EM,Ardizzoni A

    更新日期:2013-07-01 00:00:00

  • Use of cytology centrifuged supernatants improves cost and turnaround time for targeted next generation sequencing.

    abstract:BACKGROUND:Molecular testing is an essential step in providing patients with advanced non-small-cell lung cancer (NSCLC), the most appropriate front-line targeted therapies. We recently implemented targeted NGS on previously discarded cytology centrifuged supernatant (CCS). METHODS:In this study, we reviewed our imple...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24548

    authors: Gokozan H,Harbhajanka A,Bomeisl P,Michael CW,Sadri N

    更新日期:2020-12-01 00:00:00

  • Cytologic diagnosis of pseudomyxoma peritonei: common and uncommon causes.

    abstract::Pseudomyxoma peritonei (PP) refers to accumulation of mucus in the peritoneal cavity, regardless of cause or pathogenesis. We have reviewed 8 cases of PP diagnosed in our institution over the past 5 years. Pertinent cytologic features include a mucinous background with mesothelial cells and histiocytes. Two cases cont...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0339(199602)14:1<10::AID-DC3>3.

    authors: Pisharodi LR,Bedrossian CW

    更新日期:1996-02-01 00:00:00

  • Atypical squamous cells of undetermined significance: A cytohistological study in a colposcopy clinic.

    abstract::Cytohistologic correlation was performed by 3 observers on 100 atypical squamous cells of undetermined significance (ASCUS) cases from a colposcopy clinic. Our objectives were to: 1) subclassify ASCUS cases and determine their clinical significance; 2) assess the independent predictive value of different cytologic par...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0339(199909)21:3<211::aid-dc14>

    authors: Ettler HC,Joseph MG,Downing PA,Suskin NG,Wright VC

    更新日期:1999-09-01 00:00:00

  • The application of immunocytochemistry to direct smears in the diagnosis of effusions.

    abstract::Metastatic malignancy represents a common cause of effusions. Immunocytochemistry (ICC) is useful in confirming malignancy and gaining insight into the site of origin. Cell blocks are commonly utilized for this purpose; nonetheless, when the malignant cells are sparse, they may not be represented in cell blocks thereb...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.22852

    authors: Knoepp SM,Placido J,Fields KL,Thomas D,Roh MH

    更新日期:2013-05-01 00:00:00

  • Pleomorphic adenoma with bizarre myoepithelial cells: A diagnostic challenge on cytologic smear.

    abstract::The diagnosis on fine needle aspiration of salivary gland tumors with a myoepithelial component is challenging because myoepithelial cells can have a wide cytomorphologic spectrum. The authors report a case of a pleomorphic adenoma of the parotid gland that expands the spectrum of appearances that myoepithelial cells ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.24301

    authors: Taweevisit M,Thorner PS

    更新日期:2019-12-01 00:00:00

  • The cytopathology of mycobacterial infection.

    abstract::Mycobacterial infection, tuberculosis (TB) in particular, remains one of the world's deadliest communicable diseases in adults and particularly in children, in low and middle income countries. The combination of human immunodeficiency virus (HIV) and TB is often lethal with TB accounting for 25% of deaths in the HIV p...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章,评审

    doi:10.1002/dc.23410

    authors: Michelow P,Omar T,Field A,Wright C

    更新日期:2016-03-01 00:00:00

  • The utility of SMAD4 as a diagnostic immunohistochemical marker for pancreatic adenocarcinoma, and its expression in other solid tumors.

    abstract::Pancreatic adenocarcinoma is a genetic disease showing somatic mutations of multiple genes, including SMAD4. SMAD4 is a tumor suppressor gene that is inactivated in a sub-set of pancreatic adenocarcinoma, either by the intragenic mutation of one allele in combination with the loss of the other allele or by homozygous ...

    journal_title:Diagnostic cytopathology

    pub_type: 杂志文章

    doi:10.1002/dc.20715

    authors: Ali S,Cohen C,Little JV,Sequeira JH,Mosunjac MB,Siddiqui MT

    更新日期:2007-10-01 00:00:00