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The expression of NLRP3, NLRP1 and AIM2 in the gingival tissue of periodontitis patients: RT-PCR study and immunohistochemistry.

Abstract：

OBJECTIVE:Detecting the distribution and intensity of NLRP3, NLRP1 and AIM2 expression in different types of periodontitis gingival tissues. MATERIALS AND METHODS:A total of 65 gingival tissues were collected from clinic and been divided into three groups: patients with chronic periodontitis (CP), patients with generalized aggressive periodontitis (G-AgP) and healthy control subjects. Real-time polymerase chain reaction (RT-PCR) was performed to detect mRNA expression of NLRP3, NLRP1 and AIM2 in full-thickness tissue. In the meanwhile, immunohistochemistry was used to detect distribution of NLRP3, NLRP1 and AIM2 in the periodontal epithelium and in the connective tissue cells. RESULTS:The overall intensity of NLRP3 expression was significantly higher in CP or G-AgP than healthy tissue. A more significant difference was observed in the periodontal epithelium layer. NLRP1 was barely expressed in the healthy and periodontitis gingival tissues, whereas AIM2 was expressed at a higher level in the chronic periodontitis group than others. CONCLUSION:The NLRP3, NLRP1 and AIM2 proteins were differentially expressed in gingival tissues from patients with CP and G-AgP and may play vital roles in the progression of periodontal inflammation to different degrees. Our studies may provide a new direction for personalized periodontal treatment.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Xue F,Shu R,Xie Y

doi

10.1016/j.archoralbio.2015.03.005

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

948-58

issue

6

eissn

0003-9969

issn

1879-1506

pii

S0003-9969(15)00070-9

journal_volume

60

pub_type

杂志文章

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