Effect of interferon α2a in cystoid macular edema due to intraocular infection.

Abstract:

PURPOSE:Cystoid macular edema (CME) is a severe complication and a major cause of visual loss in patients with intraocular infection. In this type of CME, therapeutic strategies remain controversial. We aimed to investigate the efficacy and tolerability of interferon (IFN)-α2a in cystoid macular edema caused by intraocular infection. METHODS:In this retrospective, noncomparative, interventional case series, 5 patients (6 eyes) who were diagnosed with intraocular infection with chronic CME were included. Interferon-α2a (3 million units 3 times a week) was administered subcutaneously. Clinical observations were recorded before and after treatment. RESULTS:The average duration of CME before treatment with IFN-α was 26 months. According to the preset criteria, IFN-α2a therapy was shown to be effective in 2 patients (3 eyes), effective dose-dependent in 2 patients, and partly effective in 1 patient, and was well-tolerated in 4 patients. The most common side effect was flu-like symptoms. CONCLUSIONS:Interferon α-2a may be an effective alternative treatment for CME due to intraocular infection that is resistant to other treatment. Studies with larger sample sizes are required to confirm this conclusion.

journal_name

Eur J Ophthalmol

authors

Qian Z,Fardeau C,Cardoso JN,Jellab B,Fan X,LeHoang P

doi

10.5301/ejo.5000591

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

431-6

issue

5

eissn

1120-6721

issn

1724-6016

pii

4B63CD6B-2F25-4E50-AE11-60D946F7F59D

journal_volume

25

pub_type

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