Abstract:
:Age-related macular degeneration is a condition (a) characterized by accumulation of membranous debris on both sides of the retinal pigment epithelium (RPE) basement membrane. Clinical manifestations of drusen, atrophy of the RPE/choriocapillaris, RPE detachment, and choroidal new vessel (CNV) formation occur after age 50 years. A hypothetical pathogenic sequence of events consistent with known data is: 1) RPE dysfunction (e.g., precipitated by an inherited susceptibility and/or environmental exposure); 2) accumulation of intracellular material in the RPE (e.g., accumulation of normal substrate material that is not enzymatically degraded properly vs. abnormal substrate material); 3) abnormal accumulation of extracellular material (basal laminar and basal linear deposit); 4) change in Bruch's membrane composition (e.g., increased lipid deposition and protein crosslinking); 5) change in Bruch's membrane parmeability to nutrients (e.g., impaired diffusion of water soluble plasma constituents across Bruch's membrane); and 6) response of the RPE to metabolic distress (i.e., atrophy vs. CNV growth). Histopathological and clinical studies indicate that areas of choroidal ischemia often are seen near CNVs in AMD patients. In response to decreased oxygen delivery/metabolic "distress", the RPE may elaborate substances leading to CNV growth. Perhaps RPE atrophy, followed by choriocapillaris and photoreceptor atrophy, is a response to decreased nutrients/increasing metabolic abnormalities in areas of excessive accumulation of extracellular debris. Unanswered questions regarding AMD include: 1) is AMD an ocular manifestation of a systemic disease or purely an ocular disease?; 2) what determines whether CNVs vs. atrophy of the RPE-choriocapillaris-photoreceptors develops?; and 3) what induces the maturation of CNVs into an inactive scar, and what limits the growth of most CNVs to the area centralis?
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Zarbin MAsubject
Has Abstractpub_date
1998-10-01 00:00:00pages
199-206issue
4eissn
1120-6721issn
1724-6016journal_volume
8pub_type
杂志文章,评审abstract:PURPOSE:To compare glare disability test results in patients with hydrophilic and hydrophobic acrylic intraocular lenses (IOL). METHODS:Sixty eyes of 60 patients were studied in three groups of 20. Each eye in Group 1 had a single-piece hydrophilic acrylic (Bioacryl, Biotech, France) IOL implant, and each eye in Group...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210401400103
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:To compare diagnostic capabilities and agreement between Oculus-Spark perimetry and 3 procedures of glaucoma morphologic analysis. METHODS:A total of 102 normal eyes and 104 consecutive eyes with suspected or confirmed glaucoma (1 eye per subject) were analyzed in a prospective observational case-control study...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000233
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To investigate color perception and contrast sensitivity with and without additional glare in pseudophakic patients with a conventional intraocular lens (IOL) in one eye and a blue light-filtering IOL in the fellow eye. METHODS:Twenty-three bilaterally pseudophakic patients with a conventional IOL (AcrySof SA6...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210901900210
更新日期:2009-03-01 00:00:00
abstract::A 50-year-old white man complained of "inflammation" of his right eyelid since January 1989. In June 1990, he had undergone a gastrectomy for an adenocarcinoma of the stomach. In August 1990, his right eye showed a painless, firm infiltration of the upper and lower lid, ulceration and loss of eyelashes of the upper li...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:To evaluate whether the addition of cataract surgery to an intravitreal injection of triamcinolone acetonide markedly increases frequency and spectrum of complications. METHODS:The comparative nonrandomized clinical interventional investigation included a study group of 60 eyes (56 patients) undergoing catarac...
journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章
doi:10.1177/112067210501500303
更新日期:2005-05-01 00:00:00
abstract:PURPOSE:To investigate the early neurodegenerative changes of inner retina and choroid in type 1 and type 2 diabetic patients without retinopathy and with early-stage retinopathy. METHODS:In this observational cross-sectional study, 90 right eyes of 90 naive type 1 and 2 diabetic patients without diabetic retinopathy ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000887
更新日期:2017-05-11 00:00:00
abstract::We present an unusual case of Sturge-Weber syndrome whose main clinical manifestations were nevus flammeus, seizures, glaucoma, and acoria. To our knowledge, the combination of Sturge-Weber syndrome and acoria has not been previously reported. ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672118804795
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:We present the clinical, pathologic, and genetic findings of the first reported case of choroidal melanoma that developed a late recurrence and aggressive metastasis to the skull base without evidence of hepatic involvement. METHODS:Retrospective chart review and clinicopathologic correlation of ocular and bra...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000468
更新日期:2014-09-01 00:00:00
abstract:PURPOSE:To evaluate the efficiency and safety of refractive lens exchange for the correction of high myopia. METHODS:We made a prospective study of the results of refractive lens exchange in 72 eyes that had undergone this surgical procedure between January 1996 and January 2001. Lens extraction by phacoemulsification...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210201200507
更新日期:2002-09-01 00:00:00
abstract::Cone-rod dystrophy (CORD) is one of the inherited retinal diseases that result in central visual field deterioration and decreased visual acuity (VA). In CORD patients, impaired photoreceptor cells are observed as the disruption of ellipsoid zone (EZ) on optical coherence tomography (OCT) images. In the present study,...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672121990561
更新日期:2021-01-26 00:00:00
abstract:INTRODUCTION:To report the first case of bilateral ocular decompression retinopathy after uneventful non-perforating deep sclerectomy with mitomycin C in a child with tubulointerstitial nephritis and uveitis syndrome. CASE DESCRIPTION:An 8-year-old girl affected by tubulointerstitial nephritis and uveitis syndrome dev...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119832177
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:To compare the efficacy and safety of latanoprost monotherapy or dorzolamide and timolol in glaucoma patients inadequately controlled on adrenergic beta-receptor antagonist therapy. METHODS:A total of 164 patients with primary open-angle glaucoma, capsular glaucoma or ocular hypertension were included in a thr...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/EJO.2008.5687
更新日期:2000-07-01 00:00:00
abstract:PURPOSE:Ibopamine is a prodrug of N-methyldopamine that has a non-cycloplegic mydriatic action due to its alpha-adrenergic properties and is able to induce, when topically given, a transient increase of intraocular pressure (IOP) in eyes with hydrodynamic disorders. METHODS:This is a randomized, crossover, open-labele...
journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:2004-11-01 00:00:00
abstract:PURPOSE:To investigate the mean values of intraocular pressure (IOP) measured with noncontact tonometer (NCT) and evaluate the factors that may affect IOP. METHODS:A total of 850 subjects who were admitted to our clinic between March 2005 and February 2006 were recruited for the study. Subjects having blepharitis, con...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210901900109
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:To describe a technique for suturing a luxated intraocular lens (IOL) in the vitreous cavity directly to the ciliary sulcus using intraocular slipknot without IOL extraction. DESIGN:Noncomparative interventional case series. MATERIALS AND METHODS:A three-port vitrectomy was performed in all cases. According t...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210301300604
更新日期:2003-07-01 00:00:00
abstract:PURPOSE:Twenty-two people with a history of grass pollen allergic conjunctivitis were enrolled outside the pollen season in this study to compare the efficacy of 0.05% mequitazine eyedrops with topical 2% disodium cromoglycate. METHODS:This randomized, double-blind study compared right and left eyes. Subjects received...
journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/112067210001000103
更新日期:2000-01-01 00:00:00
abstract:PURPOSE:To determine the microbial contamination of the irrigating fluids at the time of phacoemulsification after the use of topical povidone-iodine and antibiotics prophylaxis. METHODS:A total of 119 patients undergoing cataract surgery were enrolled in this prospective study. All patients received 5 mg/mL levofloxa...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/EJO.2011.8434
更新日期:2012-03-01 00:00:00
abstract:PURPOSE:Fabry disease retinal vascular involvement has been widely reported, with narrowing of the retinal arterioles, dilation and irregularity of the retinal veins, and exaggerated tortuosity of the retinal vessels. We evaluated retinal vessel diameter in Fabry disease, by means of a dedicated software, aiming to pro...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119886985
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:To assess efficacy, safety, and predictability after refractive lens exchange (RLE) in patients who had bilateral implantation of an Acri.LISA 366D diffractive bifocal intraocular lens (IOL). METHODS:Sixty-six eyes of 33 consecutive patients were examined after RLE who had bilateral implantation of an Acri.LIS...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.2010.2991
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:To study the effect of deep sclerectomy (DS) in primary open-angle glaucoma (POAG) and exfoliative glaucoma (EXG). METHODS:We retrospectively analyzed the intraocular pressure (IOP)-lowering effect of DS in 235 consecutive eyes. Eyes were divided into 2 groups according to glaucoma subtype: POAG (127 eyes) and...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000762
更新日期:2016-11-04 00:00:00
abstract:PURPOSE:To verify the functional and anatomical results of retinal detachments related to choroidal coloboma. METHODS:Seven eyes with retinal detachment secondary to retinal breaks at the margin of or within a choroidal coloboma were analysed retrospectively. RESULTS:Scleral buckling was performed in five of the seve...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210201200408
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:To describe the impact that social media usage has on a group of retina specialists. MATERIALS AND METHODS:An anonymous online survey was sent to members of the Young Retina Forum who use the social media platform - Telegram. RESULTS:Of a total of 178 members, 100 responded (87 men and 13 wom...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119832186
更新日期:2020-07-01 00:00:00
abstract:PURPOSE:To evaluate and compare the glaucoma discrimination ability of macula, macular ganglion cell complex (mGCC), and peripapillary nerve fiber layer (ppNFL) thickness in Chinese patients using Fourier-domain optical coherence tomography (FD-OCT). METHODS:A total of 64 normal subjects (N), 47 glaucoma suspects (GS)...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000131
更新日期:2012-11-01 00:00:00
abstract:PURPOSE:To describe the long-term clinical course of patients with low-pressure glaucoma (LPG) and to assess the risk factors for disease progression. METHODS:The Wills Eye Glaucoma Research Center retrospectively reviewed the charts of LPG patients with documented follow-up of >8 years between 2000 and 2013. Medical ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000624
更新日期:2015-11-01 00:00:00
abstract:PURPOSE:To calculate the reliability of an eye-dedicated triaging system named Rome Eye Scoring System for Urgency and Emergency (RESCUE). METHODS:There were four coding parameters: pain, redness, loss of vision, and risk of open globe. Each parameter is assigned a score, the sum of which allows color coding. There we...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210801800321
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine the intra-session repeatability and inter-examiner reproducibility of the colour perimetry technique when assessing in vivo macular pigment optical density in age-related macular degeneration patients. METHODS:Age-related macular degeneration patients were classified i...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119870362
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:To document incidence of and risk factors for development of retinopathy of prematurity (ROP) in a population of low birthweight infants (< 1500 g). METHODS:The authors registered clinical characteristics (birthweight, gestational age (GA), Clinical Risk Index for Babies (CRIB), Apgar score, respiratory charac...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672103013009-1009
更新日期:2003-11-01 00:00:00
abstract:PURPOSE:Malignant melanoma associated with a blue nevus is a rare diagnosis. Additionally, only a handful of cases of malignant melanoma associated with blue nevi involving the ocular structures have been reported. We report a probable case of malignant melanoma associated with a blue nevus with metastasis to multiple ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/EJO.2011.6375
更新日期:2011-09-01 00:00:00
abstract:PURPOSE::To describe the optical coherence tomography angiography characteristics of myopic patients with choroidal neovascularization secondary to pathologic myopia during ranibizumab therapy. METHODS::Nineteen patients were enrolled in this prospective study (13 females, 6 males, mean age 55.25 ± 9.63 years) for a t...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672118785495
更新日期:2019-03-01 00:00:00
abstract:PURPOSE:To report a case of a combined branch retinal artery and vein occlusion in a patient with hepatitis C treated with interferon and ribavirin. METHODS:A 29-year-old man with a 1-week history of sudden visual field defect and decrease of central visual acuity was examined. RESULTS:Ophthalmoscopy and fluorescein ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/EJO.2008.4623
更新日期:2005-01-01 00:00:00