Abstract:
PURPOSE:Ibopamine is a prodrug of N-methyldopamine that has a non-cycloplegic mydriatic action due to its alpha-adrenergic properties and is able to induce, when topically given, a transient increase of intraocular pressure (IOP) in eyes with hydrodynamic disorders. METHODS:This is a randomized, crossover, open-labeled, two- center study. Forty patients (20 open-angle glaucoma patients and 20 healthy subjects) were treated with ibopamine 2% eye drops and phenylephrine 10% eye drops. RESULTS:Ibopamine induced a significant increase in IOP only in glaucomatous eyes (p<0.001) without a significant hypertensive effect in normal eyes. Ibopamine and phenylephrine showed a similar mydriatic activity but ibopamine was able to induce an hypertensive effect only in glaucomatous eyes. CONCLUSIONS:The results confirm the use of ibopamine as provocative test in detection of hydrodynamic disorders.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Giuffrè I,Taverniti L,Di Staso Ssubject
Has Abstractpub_date
2004-11-01 00:00:00pages
508-13issue
6eissn
1120-6721issn
1724-6016journal_volume
14pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract:INTRODUCTION:The aim of the study was to evaluate complications of cataract surgery in eyes filled with silicone oil. METHODS:This retrospective, noncomparative, consecutive case series analyzed medical files of patients with eyes filled with silicone oil undergoing cataract surgery. Phacoemulsification with posterior...
journal_title:European journal of ophthalmology
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journal_title:European journal of ophthalmology
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journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
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