Abstract：
PURPOSE:We present the clinical, pathologic, and genetic findings of the first reported case of choroidal melanoma that developed a late recurrence and aggressive metastasis to the skull base without evidence of hepatic involvement. METHODS:Retrospective chart review and clinicopathologic correlation of ocular and brain tissue, including sequencing of BAP1 for mutations. RESULTS:A 55-year-old woman was diagnosed with choroidal melanoma and treated with proton radiotherapy. Six years later, she developed a rapidly growing local recurrence involving the ciliary body and iris. Upon enucleation, histopathology revealed an iris and ciliary body epithelioid melanoma that was contiguous with the previously treated, regressed spindle cell choroidal melanoma. Imaging was initially negative for brain involvement. Two months later, she developed cranial neuropathies and was found to have a large skull base lesion that required surgical debulking for pain palliation. Histopathology confirmed the lesion to be metastatic melanoma. Both ocular and brain tumor specimens were wild-type for BAP1. Throughout her course, she developed no hepatic metastases. CONCLUSIONS:Uveal melanoma may metastasize to the skull base. The present case was characterized by delayed onset and unusual aggressiveness of the metastatic disease, and lack of BAP1 mutation. The unusual course highlights a unique phenotype that may reflect an alternate molecular mechanism for metastatic disease.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Yonekawa Y,Kim IK,Gragoudas ES,Njauw CN,Tsao H,Jakobiec FA,Stacy RCdoi
10.5301/ejo.5000468subject
Has Abstractpub_date
2014-09-01 00:00:00pages
811-3issue
5eissn
1120-6721issn
1724-6016pii
9A1C2550-4FCB-4EA7-B9A7-263848076355journal_volume
24pub_type
杂志文章abstract：PURPOSE:To evaluate the choroidal vascularity index of eyes for acute and chronic central serous chorioretinopathy patients using swept-source optical coherence tomography generated en-face scans. METHODS:This was a retrospective study, in which slabs of en-face optical coherence tomography scans, at 5 μm intervals, s...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120908719
更新日期：2020-02-27 00:00:00
abstract：PURPOSE:To report a case of bilateral retinocytoma associated with calcified vitreous deposits. METHODS:Case report. RESULTS:On routine examination, a 35-year-old asymptomatic father of a child with bilateral retinoblastoma presented bilateral retinocytoma associated with vitreous calcifications, in the vicinity of t...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210601600227
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND:Lowe syndrome is a rare X-linked disease that is characterized by renal dysfunction, developmental delays, congenital cataracts and glaucoma. Mutations in the oculocerebral renal syndrome of Lowe (OCRL) gene are found in Lowe syndrome patients. Although loss of vision is a major concern for families and phys...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120920544
更新日期：2020-09-01 00:00:00
abstract：PURPOSE:To assess the relationship of ocular pulse amplitude (OPA), as measured by dynamic contour tonometry (DCT), with structural and functional damage in patients with open-angle glaucoma (OAG). METHODS:In this cross-sectional, observational study, 242 eyes of 139 patients with OAG underwent Goldmann applanation to...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000043
更新日期：2012-01-01 00:00:00
abstract：:The two most frequent sites of obstruction of the lacrimal pathways are under the lacrimal sac, in the ductus lacrimonasalis, and over the lacrimal sac, in the canaliculi. The obstruction of the first type already has a satisfactory solution with the different forms of dacryo-cysto-rhinostomies. Obstruction of the sec...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：PURPOSE:To verify the functional and anatomical results of retinal detachments related to choroidal coloboma. METHODS:Seven eyes with retinal detachment secondary to retinal breaks at the margin of or within a choroidal coloboma were analysed retrospectively. RESULTS:Scleral buckling was performed in five of the seve...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210201200408
更新日期：2002-07-01 00:00:00
abstract：AIM:To review published literature concerning cataract surgery and dry eye disease (DED). METHODS:A search was undertaken using the following: PubMed (all years), Web of Science (all years), Ovid MEDLINE(R) (1946 to 12 December 2019), Ovid MEDLINE(R) Daily Update 10 December 2019, MEDLINE and MEDLINE non-indexed items...
journal_title：European journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.1177/1120672120929958
更新日期：2020-09-01 00:00:00
abstract：PURPOSE::To describe the patterns of regression of choroidal melanoma after treatment with plaque brachytherapy. METHODS::Retrospective interventional case series including 170 consecutive patients treated with 103Pd eye plaque radiation for choroidal melanoma. Outcome measures were changes in tumor thickness, surface...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672118776146
更新日期：2018-11-01 00:00:00
abstract：PURPOSE:To compare the efficacy of selective laser trabeculoplasty (SLT) to argon laser trabeculoplasty (ALT) as treatment and retreatment to lower intraocular pressure (IOP) in patients with uncontrolled open-angle glaucoma (OAG) on maximally tolerated medication therapy with a follow-up of 12 months. METHODS:A total...
journal_title：European journal of ophthalmology
pub_type： 杂志文章,随机对照试验
doi：10.1177/112067210901900317
更新日期：2009-05-01 00:00:00
abstract：PURPOSE:To prospectively compare the clinical results of two cataract surgery procedures through a 4.0-mm incision, differing only in the wound location (superior or lateral). METHODS:168 eyes with cataract were randomly assigned to either procedure. Except for incision location, surgical methods were identical. Uncor...
journal_title：European journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-10-01 00:00:00
abstract：PURPOSE:To report a case of monolateral preretinal fibrovascularproliferations in a young adult woman, who had suffered from incontinentia pigmenti (IP) during her first month of life. METHODS:Case report. RESULTS:Circumscribed preretinal fibrovascular proliferations, adjacent to a mid-peripheral area of snail track ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210201200418
更新日期：2002-07-01 00:00:00
abstract：PURPOSE:To evaluate optical coherence tomography (OCT) modifications of outer retinal layers as determinants for functional recovery after surgery for idiopathic macular hole (IMH). METHODS:This prospective study included 23 eyes of 23 consecutive patients who underwent vitreoretinal surgery for IMH. We excluded patie...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000905
更新日期：2017-03-10 00:00:00
abstract：PURPOSE:To report clinical findings and surgical management of 4 patients with congenital nystagmus who presented with a new or reversal of their original horizontal compensatory head posture (CHP) after Anderson-Kestenbaum (A-K) surgery. METHOD:Retrospective chart review. RESULTS:All 4 patients demonstrated a 40°-45...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/EJO.2011.8356
更新日期：2012-03-01 00:00:00
abstract：PURPOSE:To determine the safety and efficacy of photodynamic therapy with verteporfin (V-PDT) in the treatment of exudative idiopathic polypoidal choroidal vasculopathy (IPCV) lesions that were not suitable for laser photocoagulation. METHODS:This was a prospective, open label study in two centers involving 30 consecu...
journal_title：European journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.1177/112067210601600506
更新日期：2006-09-01 00:00:00
abstract：PURPOSE:To evaluate the effect and safety of fovea-sparing internal limiting membrane (ILM) peeling (FSIP) for myopic traction maculopathy comparing with that of total ILM peeling (TP). METHODS:PubMed, Web of science, Embase, Cochrane, EBSCO and CNKI, published until January 2020, were searched. Postoperative best-cor...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672120970111
更新日期：2020-11-03 00:00:00
abstract：:In renal failure the incidence of pingueculae is significantly higher than in a comparable control group but there is no evidence that the calcific precipitation in renal failure is of a dystrophic nature. The lime salts are not located within the area of elastotic degeneration, a prerequisite for dystrophic degenerat...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：PURPOSE:The aim of this study is to evaluate the incidence, natural course, and distribution pattern of superficial punctate keratopathy and describe the changes in signs and symptoms of dry eye after cataract surgery. SETTING:The setting of this study is University Hospital Rio Hortega and Instituto Universitario de ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672119896427
更新日期：2020-11-01 00:00:00
abstract：PURPOSE:To describe the management with intracameral recombinant tissue plasminogen activator (rtPA) of severe fibrin effusion after phacoemulsification, and its prevention with sustained-release dexamethasone intravitreal implant. METHODS:A 59-year-old man with chronic HLA-B27-associated uveitis underwent phacoemulsi...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000442
更新日期：2014-07-01 00:00:00
abstract：PURPOSE:To evaluate the safety and efficacy of intravitreal injections of crystalline triamcinolone acetonide as an adjunctive procedure in pars plana vitrectomy for proliferative diabetic retinopathy. METHODS:This nonrandomized comparative study included 30 patients (32 eyes) who underwent standardized pars plana vit...
journal_title：European journal of ophthalmology
pub_type： 临床试验,杂志文章
doi：10.1177/112067210301300508
更新日期：2003-06-01 00:00:00
abstract：PURPOSE:To illustrate the successful outcome of pars plana vitrectomy (PPV) with melphalan irrigation for vitreous hemorrhage (VH) with suspected viable retinoblastoma. Despite the high risk of intraocular surgery, it was performed to preserve the only potentially seeing eye with treated retinoblastoma. METHODS:Vitreo...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000683
更新日期：2015-12-01 00:00:00
abstract：PURPOSE:Parry-Romberg syndrome (PRS) is a rare disease of unknown etiology and pathogenesis, characterized by progressive hemifacial atrophy. Diverse ocular manifestations were reported in association with PRS, including enophthalmos, lid retraction, blepharoptosis, restrictive strabismus, ocular motor nerve dysfunctio...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067211002000132
更新日期：2010-01-01 00:00:00
abstract：PURPOSE:To report on a case of episcleral hemangioma in a child. METHODS:A 3-year-old boy presented with a 4-week history of limbal mass in the left eye and had an excision of that mass. RESULTS:There was an 8 x 7 mm oval lesion, 3-4 mm below the inferior limbus. It was reddish, sharply elevated with smooth surface, ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210901900220
更新日期：2009-03-01 00:00:00
abstract：OBJECTIVE:To investigate the potential correlation between complement factor B polymorphisms and age-related macular degeneration. METHODS:We retrieved relevant articles systematically by searching PubMed and Web of Science databases. The pooled odds ratios and 95% confidence intervals were calculated for five complem...
journal_title：European journal of ophthalmology
pub_type： 杂志文章,meta分析
doi：10.1177/1120672119840245
更新日期：2020-07-01 00:00:00
abstract：PURPOSE:To evaluate the safety of a foldable acrylic single-piece intraocular lens (IOL) in cases of complicated cataract surgery and sulcus implantation. The setting was University and private anterior segment surgery practices. METHODS:In this observational case series study, 13 eyes of 13 patients were included aft...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/ejo.5000160
更新日期：2012-11-01 00:00:00
abstract：PURPOSE:To describe a clinical case of corneoscleral xanthogranuloma, a rare manifestation of juvenile xanthogranuloma, and xanthoma disseminatum, which responded well to chemotherapy. METHODS:Interventional case report and literature search. RESULTS:A 9-year-old female patient with a disseminated disease showed comp...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672119832187
更新日期：2020-03-01 00:00:00
abstract：PURPOSE:To report the off-label use of systemic bevacizumab in a patient with stage 3 retinal angiomatous proliferation (RAP) associated with a vascularized pigmented epithelium detachment (PED). METHODS:Interventional case report. RESULTS:The patient was treated with systemic bevacizumab after obtaining fully inform...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/112067210701700621
更新日期：2007-11-01 00:00:00
abstract：PURPOSE:To compare the IOP readings of an ocular blood flow (OBF) tonograph (OBF Labs UK Ltd) with Goldmann applanation tonometry. METHODS:194 patients were studied. In group 1, the software version 8.2 of the OBF tonograph was used in 214 eyes of 107 patients and in group 2, the 11.2 version of the tonograph was used...
journal_title：European journal of ophthalmology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1998-07-01 00:00:00
abstract：PURPOSE:To report a case of a combined branch retinal artery and vein occlusion in a patient with hepatitis C treated with interferon and ribavirin. METHODS:A 29-year-old man with a 1-week history of sudden visual field defect and decrease of central visual acuity was examined. RESULTS:Ophthalmoscopy and fluorescein ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.5301/EJO.2008.4623
更新日期：2005-01-01 00:00:00
abstract：PURPOSE::To evaluate the predictive value of magnetic resonance imaging in retinoblastoma for the likelihood of high-risk pathologic features. METHODS::A retrospective study of 64 eyes enucleated from 60 retinoblastoma patients. Contrast-enhanced magnetic resonance imaging was performed before enucleation. Main outcom...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：10.1177/1120672118781200
更新日期：2019-03-01 00:00:00
abstract：PURPOSE:The purpose of this study was to assess indications and outcome of carotid Doppler ultrasound requested by ophthalmologists from an eye hospital over a period of three years. METHODS:This retrospective study was designed to analyse data for all patients referred to have carotid Doppler ultrasound from 1999 to ...
journal_title：European journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：2004-05-01 00:00:00
