Abstract：
BACKGROUND:Dermatofibrosarcoma protuberans with fibrosarcomatous differentiation (DFSP-FS) is a rare variant of DFSP with a more aggressive clinical course, characterized by higher rates of local recurrence, metastasis, and death. METHODS:We conducted a clinicopathologic review of all DFSP-FS cases that occurred in Alberta, Canada, from 1997 to 2007. RESULTS:Of the 75 DFSP cases reviewed, 4 demonstrated fibrosarcomatous differentiation. Three patients were female and one was male, and the age range was 25 to 76 years. Three tumors invaded to skeletal muscle, whereas one invaded to subcutaneous tissue only. Although perineural invasion was noted in all four cases, none exhibited lymphovascular space invasion. One local recurrence developed, and two of four tumors metastasized. Metastasis was associated with tumor size, tumor necrosis, grenz zone involvement, ulceration, thickness, and tumor grade. One patient died within 5 years of diagnosis. CONCLUSION:DFSP-FS represents a more aggressive subtype of DFSP. Several features of DFSP-FS may impart a higher risk of metastasis.
journal_name
J Cutan Med Surgjournal_title
Journal of cutaneous medicine and surgeryauthors
Kuzel P,Mahmood MN,Metelitsa AI,Salopek TGdoi
10.2310/7750.2014.13192subject
Has Abstractpub_date
2015-01-01 00:00:00pages
28-34issue
1eissn
1203-4754issn
1615-7109pii
19/1/28journal_volume
19pub_type
杂志文章abstract：BACKGROUND:Squamous cell carcinoma (SCC) is the second-most common form of non-melanoma skin cancer (NMSC). OBJECTIVE:To provide guidance to Canadian health care practitioners regarding management of SCCs. METHODS:Literature searches and development of graded recommendations were carried out as discussed in the accom...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,实务指引
doi：10.1177/1203475415582318
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Informed shared decision making is a mutual process engaging both doctor and patient and informed by best medical evidence and patient values and preferences. OBJECTIVE:Our aim was to identify the needs of psoriasis patients in decisions on selecting treatment. METHODS:Psoriasis subjects participated in an...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2010.09049
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND:Sarcoidosis is a systemic granulomatous disease of unknown etiology that affects multiple organ systems, including the pulmonary, lymphatic, skeletal, and integumentary systems. Improved understanding of the intrinsic immunology and molecular biology in sarcoidosis can be applied to the treatment of this dis...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2006.00063
更新日期：2006-11-01 00:00:00
abstract：BACKGROUND:Local skin reactions are common during imiquimod treatment of actinic keratosis (AK). Cyclical application of imiquimod may improve tolerability while maintaining efficacy. OBJECTIVE:To assess the tolerability of imiquimod and clearance rate of AK lesions after imiquimod application. METHODS:Imiquimod 5% c...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2008.07045
更新日期：2008-05-01 00:00:00
abstract：BACKGROUND:Sun-induced malignancies (basal cell and squamous cell carcinomas) are common in oculocutaneous albinism, however, the incidence of malignant melanoma is a topic of controversy. OBJECTIVE:We have reviewed the literature and report a case of a woman with oculocutaneous albinism with an amelanotic melanoma of...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/120347540000400307
更新日期：2000-07-01 00:00:00
abstract：BACKGROUND:The number of dermatology residency positions in Canada has not reflected the growing workforce shortage. Until 2005, all dermatology residents at the University of Ottawa were committed to return to their funding area at the completion of their training. This has left Eastern Ontario with a critical shortag...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2008.07071
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND:Acne affects a large proportion of the Canadian population and has psychosocial and financial consequences. OBJECTIVE:We provide cost information for treatments recommended by the Canadian acne guidelines. METHODS:Highest level recommendations were selected for 3-month usage cost. RESULTS:Three-month esti...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475416653735
更新日期：2016-11-01 00:00:00
abstract：:The Maintenance of Certification (MOC) Program administered by the Royal College of Physicians and Surgeons applies to all Fellows of the Royal College including dermatologists. It is mandatory for those who wish to maintain their fellowship in the Royal College and can be critical for maintaining licensure requiremen...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475417709194
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Major advances have been made in the understanding of the pathophysiology of psoriasis. OBJECTIVES:The authors review the role of interleukin (IL) 17 in the pathogenesis of psoriasis and provide updates on approved and investigational therapies targeting IL-17 and the IL-17 receptor. METHODS:A PubMed searc...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1177/1203475416651605
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Genital herpes is a very common sexually transmitted disease. Safe and effective therapies are needed for patients with frequent recurrences. OBJECTIVE:The aim of our study was to determine the efficacy and safety of famciclovir for suppression of herpes simplex virus (HSV) infection in patients with histor...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2003-11-01 00:00:00
abstract：BACKGROUND:We present a case of strongyloidiasis presenting as larva currens 38 years after potential exposure in a country with what is typically thought of as low epidemiologic risk. CONCLUSION:This case highlights several important features of strongyloidiasis, including its varied epidemiology, long incubation per...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/120347541201600613
更新日期：2012-11-01 00:00:00
abstract：:We present the extraordinary case of a 72-year-old man with a history of primary cutaneous peripheral T-cell lymphoma not otherwise specified (pcPTCL-NOS) previously controlled with topical agents who developed tumours in a sporotrichoid pattern. Culture of the tumours was negative, and histopathology showed findings ...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475417721425
更新日期：2017-11-01 00:00:00
abstract：:Leprosy reactions are acute inflammatory episodes that occur in the setting of Mycobacterium leprae infection. Precipitants of reactions can be pharmacologic and nonpharmacologic. Both type 1 and type 2 reactions typically occur before and during leprosy treatment but may also occur after treatment has been completed....
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475416644832
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Dabrafenib, a novel selective small-molecule inhibitor of BRAF, has been shown to increase overall survival in patients with unresectable metastatic melanoma harboring the BRAF V600E mutation. The development of resistance has led to combination therapy with selective MEK inhibitor trametinib. Compared with ...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475416670368
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Onychomycosis is a persistent fungal nail infection that is notoriously hard to treat. Approximately 20% to 25% of patients with onychomycosis do not respond to treatment, and 10% to 53% of patients relapse. As such, successful treatment is imperative for long-term disease management. OBJECTIVE:To identify ...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1177/1203475416653734
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Oral psychostimulant (PS) drugs, the pharmacologic treatment of choice for attention-deficit/hyperactivity disorder (ADHD), have been associated with diseases of abnormal sensitivity to cold (DASC) such as Raynaud phenomenon and acrocyanosis. OBJECTIVES:In a cohort of pediatric patients with DASC, we sought...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2014.14052
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:Elastosis perforans serpiginosa (EPS) is a rare skin disease in which abnormal elastic tissue fibers, other connective tissue elements, and cellular debris are expelled from the papillary dermis via transepithelial elimination. It is characterized by an eruption of small grouped hyperkeratotic papules in a s...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.2310/7750.2009.08064
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:In 1995, a Rosacea Awareness Program (RAP) was initiated in Canada to make available educational resources for physicians and rosacea patients. Material is in French or English, and is accessible though physician offices and by toll-free telephone. Information was communicated to the public via noncommercial...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/120347549900300403
更新日期：1999-04-01 00:00:00
abstract：BACKGROUND:Mast cells stimulate inflammation and itch sensation in the skin by releasing various mediators when they are activated. Stress exacerbates some skin diseases. We have reported that inhalation of certain odorants modulates immune reactions in the skin. OBJECTIVE:The possible usage of odorants in the regulat...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1007/s10227-002-0129-y
更新日期：2003-07-01 00:00:00
abstract：BACKGROUND:Forty-nine years ago the first complete and authoritative English text on the physiology and biochemistry of the skin was published by Stephen Rothman, an early basic researcher in dermatology. OBJECTIVE:The purpose of the article is to learn more about Stephen Rothman and his 1954 text, to learn more about...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 传,历史文章,杂志文章
doi：10.1007/s10227-005-0040-4
更新日期：2004-09-01 00:00:00
abstract：:Sarcoidosis is a multisystem inflammatory condition of unknown etiology. Variability in the cutaneous features of sarcoidosis is profound, and its protean manifestations affirm the condition's designation as one of dermatology's "great mimics." Cutaneous phenotypes of sarcoidosis include but are by no means limited to...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/1203475418763590
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:The gtring presence of dermatology platforms on Facebook has been acknowledged; however, little is known about the extent to which different types of content influence the level of engagement with online users. OBJECTIVE:To assess the level of public engagement with different types of content posted on Face...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2014.14119
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Vemurafenib is an oral BRAF inhibitor recently approved for the treatment of metastatic melanoma. Patients treated with this medication have been reported to have the occurrence of squamous cell carcinoma (SCC) and/or actinic keratosis (AK). OBJECTIVE:We report the case of a patient treated with vemurafenib...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2013.12092
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:In addition to corticosteroids, there are increasing numbers of anti-inflammatory agents that specifically target bioactive lipids generated from arachidonic acid. Knowledge of the diverse mechanisms of action of these different bioactive lipids holds promise in the therapy of a wide spectrum of cutaneous an...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章,评审
doi：10.1007/s10227-001-0047-4
更新日期：2002-05-01 00:00:00
abstract：BACKGROUND:Any scientific discipline needs a sharply defined set of words for exact and reproducible communication. Surprisingly this has never been a strong point in dermatological science, especially as regards the living gross pathology of skin disease. OBJECTIVE:This article briefly reviews the four editions of a ...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1007/s10227-001-0016-y
更新日期：2001-11-01 00:00:00
abstract：BACKGROUND:To date, there is no standard treatment of folliculitis decalvans (FD), a rare type of cicatricial alopecia. OBJECTIVE AND METHODS:The records of 23 patients with FD (1998-2012) were retrospectively analyzed, with added data review on the course and treatment of long-standing cases. RESULTS:Initial managem...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:The self-inflicted dermatoses such as acne excorieé and neurotic excoriations are often chronic, recurring, and resistant to standard dermatologic therapies. OBJECTIVE:We present a 28-year-old woman with longstanding acne excorieé, whose acne started at age 14 years and was followed by acne excorieé at age ...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1177/120347540100500106
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:Although betamethasone valerate (BMV) foam, 0.12% (Luxiq, Connectics Corporation, Palo Alto, CA) is approved by the Food and Drug Administration for the treatment of corticosteroid-responsive scalp dermatoses, no data are available for its use on nonscalp psoriasis. OBJECTIVE:We evaluated the safety and eff...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:Cytomegalovirus (CMV) infection usually remains asymptomatic in immunocompetent adults, and few cases of complicated disease in nonimmunosuppressed patients have been reported. Erythema multiforme (EM), an acute and self-limiting skin eruption characterized by a typical targetoid lesion that may also affect ...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.2310/7750.2011.10020
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND:Aquagenic pruritus is an intense prickling sensation that develops in affected individuals immediately after contact with water at any temperature. It is most commonly associated with polycythemia rubra vera. Common but often ineffective treatments include anticholinergics and antihistamines. Other moderatel...
journal_title：Journal of cutaneous medicine and surgery
pub_type： 杂志文章
doi：10.1007/s10227-005-0144-x
更新日期：2005-10-01 00:00:00
