A clinicopathologic review of a case series of dermatofibrosarcoma protuberans with fibrosarcomatous differentiation.

Abstract:

BACKGROUND:Dermatofibrosarcoma protuberans with fibrosarcomatous differentiation (DFSP-FS) is a rare variant of DFSP with a more aggressive clinical course, characterized by higher rates of local recurrence, metastasis, and death. METHODS:We conducted a clinicopathologic review of all DFSP-FS cases that occurred in Alberta, Canada, from 1997 to 2007. RESULTS:Of the 75 DFSP cases reviewed, 4 demonstrated fibrosarcomatous differentiation. Three patients were female and one was male, and the age range was 25 to 76 years. Three tumors invaded to skeletal muscle, whereas one invaded to subcutaneous tissue only. Although perineural invasion was noted in all four cases, none exhibited lymphovascular space invasion. One local recurrence developed, and two of four tumors metastasized. Metastasis was associated with tumor size, tumor necrosis, grenz zone involvement, ulceration, thickness, and tumor grade. One patient died within 5 years of diagnosis. CONCLUSION:DFSP-FS represents a more aggressive subtype of DFSP. Several features of DFSP-FS may impart a higher risk of metastasis.

journal_name

J Cutan Med Surg

authors

Kuzel P,Mahmood MN,Metelitsa AI,Salopek TG

doi

10.2310/7750.2014.13192

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

28-34

issue

1

eissn

1203-4754

issn

1615-7109

pii

19/1/28

journal_volume

19

pub_type

杂志文章
  • Non-melanoma Skin Cancer in Canada Chapter 5: Management of Squamous Cell Carcinoma.

    abstract:BACKGROUND:Squamous cell carcinoma (SCC) is the second-most common form of non-melanoma skin cancer (NMSC). OBJECTIVE:To provide guidance to Canadian health care practitioners regarding management of SCCs. METHODS:Literature searches and development of graded recommendations were carried out as discussed in the accom...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,实务指引

    doi:10.1177/1203475415582318

    authors: Sapijaszko M,Zloty D,Bourcier M,Poulin Y,Janiszewski P,Ashkenas J,Canadian Non-melanoma Skin Cancer Guidelines Committee.

    更新日期:2015-05-01 00:00:00

  • Treatment decision needs of psoriasis patients: cross-sectional survey.

    abstract:BACKGROUND:Informed shared decision making is a mutual process engaging both doctor and patient and informed by best medical evidence and patient values and preferences. OBJECTIVE:Our aim was to identify the needs of psoriasis patients in decisions on selecting treatment. METHODS:Psoriasis subjects participated in an...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.2310/7750.2010.09049

    authors: Tan J,Stacey D,Fung K,Barankin B,Bissonnette R,Gulliver W,Lui H,Shear N,Jackson C,Zhang X

    更新日期:2010-09-01 00:00:00

  • Cutaneous sarcoidosis successfully treated with alefacept.

    abstract:BACKGROUND:Sarcoidosis is a systemic granulomatous disease of unknown etiology that affects multiple organ systems, including the pulmonary, lymphatic, skeletal, and integumentary systems. Improved understanding of the intrinsic immunology and molecular biology in sarcoidosis can be applied to the treatment of this dis...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.2310/7750.2006.00063

    authors: Garcia-Zuazaga J,Korman NJ

    更新日期:2006-11-01 00:00:00

  • Open-label study to assess the safety and efficacy of imiquimod 5% cream applied once daily three times per week in cycles for treatment of actinic keratoses on the head.

    abstract:BACKGROUND:Local skin reactions are common during imiquimod treatment of actinic keratosis (AK). Cyclical application of imiquimod may improve tolerability while maintaining efficacy. OBJECTIVE:To assess the tolerability of imiquimod and clearance rate of AK lesions after imiquimod application. METHODS:Imiquimod 5% c...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.2310/7750.2008.07045

    authors: Rivers JK,Rosoph L,Provost N,Bissonnette R

    更新日期:2008-05-01 00:00:00

  • Malignant melanoma in a patient with oculocutaneous albinism.

    abstract:BACKGROUND:Sun-induced malignancies (basal cell and squamous cell carcinomas) are common in oculocutaneous albinism, however, the incidence of malignant melanoma is a topic of controversy. OBJECTIVE:We have reviewed the literature and report a case of a woman with oculocutaneous albinism with an amelanotic melanoma of...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/120347540000400307

    authors: Streutker CJ,McCready D,Jimbow K,From L

    更新日期:2000-07-01 00:00:00

  • Canaries in the mineshaft: the dermatology workforce shortage in Eastern Ontario.

    abstract:BACKGROUND:The number of dermatology residency positions in Canada has not reflected the growing workforce shortage. Until 2005, all dermatology residents at the University of Ottawa were committed to return to their funding area at the completion of their training. This has left Eastern Ontario with a critical shortag...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.2310/7750.2008.07071

    authors: Heughan C,Kanigsberg N,Amdemichael E,Fergusson D,Ammerman D

    更新日期:2008-09-01 00:00:00

  • Cost of Medications Recommended by Canadian Acne Clinical Practice Guidelines.

    abstract:BACKGROUND:Acne affects a large proportion of the Canadian population and has psychosocial and financial consequences. OBJECTIVE:We provide cost information for treatments recommended by the Canadian acne guidelines. METHODS:Highest level recommendations were selected for 3-month usage cost. RESULTS:Three-month esti...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/1203475416653735

    authors: Czilli T,Tan J,Knezevic S,Peters C

    更新日期:2016-11-01 00:00:00

  • Maintenance of Certification: What's to Know.

    abstract::The Maintenance of Certification (MOC) Program administered by the Royal College of Physicians and Surgeons applies to all Fellows of the Royal College including dermatologists. It is mandatory for those who wish to maintain their fellowship in the Royal College and can be critical for maintaining licensure requiremen...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/1203475417709194

    authors: Rich P

    更新日期:2017-07-01 00:00:00

  • The Role of IL-17 in the Pathogenesis of Psoriasis and Update on IL-17 Inhibitors for the Treatment of Plaque Psoriasis.

    abstract:BACKGROUND:Major advances have been made in the understanding of the pathophysiology of psoriasis. OBJECTIVES:The authors review the role of interleukin (IL) 17 in the pathogenesis of psoriasis and provide updates on approved and investigational therapies targeting IL-17 and the IL-17 receptor. METHODS:A PubMed searc...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1177/1203475416651605

    authors: AbuHilal M,Walsh S,Shear N

    更新日期:2016-11-01 00:00:00

  • Oral famciclovir for the suppression of recurrent genital herpes: the combined data from two randomized controlled trials.

    abstract:BACKGROUND:Genital herpes is a very common sexually transmitted disease. Safe and effective therapies are needed for patients with frequent recurrences. OBJECTIVE:The aim of our study was to determine the efficacy and safety of famciclovir for suppression of herpes simplex virus (HSV) infection in patients with histor...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s10227-002-0141-2

    authors: Tyring SK,Diaz-Mitoma F,Shafran SD,Locke LA,Sacks SL,Young CL

    更新日期:2003-11-01 00:00:00

  • Strongyloidiasis presenting as larva currens 38 years after presumed exposure.

    abstract:BACKGROUND:We present a case of strongyloidiasis presenting as larva currens 38 years after potential exposure in a country with what is typically thought of as low epidemiologic risk. CONCLUSION:This case highlights several important features of strongyloidiasis, including its varied epidemiology, long incubation per...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/120347541201600613

    authors: Showler A,Boggild AK

    更新日期:2012-11-01 00:00:00

  • Primary Cutaneous Peripheral T-Cell Lymphoma in a Sporotrichoid Pattern: A Case Report.

    abstract::We present the extraordinary case of a 72-year-old man with a history of primary cutaneous peripheral T-cell lymphoma not otherwise specified (pcPTCL-NOS) previously controlled with topical agents who developed tumours in a sporotrichoid pattern. Culture of the tumours was negative, and histopathology showed findings ...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/1203475417721425

    authors: Lewis DJ,Vin H,Hinojosa T,Tetzlaff MT,Dabaja BS,Duvic M

    更新日期:2017-11-01 00:00:00

  • Clinical Pearls: Leprosy Reactions.

    abstract::Leprosy reactions are acute inflammatory episodes that occur in the setting of Mycobacterium leprae infection. Precipitants of reactions can be pharmacologic and nonpharmacologic. Both type 1 and type 2 reactions typically occur before and during leprosy treatment but may also occur after treatment has been completed....

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/1203475416644832

    authors: Wu J,Boggild AK

    更新日期:2016-09-01 00:00:00

  • Prospective Case Series of Cutaneous Adverse Effects Associated With Dabrafenib and Trametinib.

    abstract:BACKGROUND:Dabrafenib, a novel selective small-molecule inhibitor of BRAF, has been shown to increase overall survival in patients with unresectable metastatic melanoma harboring the BRAF V600E mutation. The development of resistance has led to combination therapy with selective MEK inhibitor trametinib. Compared with ...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/1203475416670368

    authors: Lacroix JP,Wang B

    更新日期:2017-01-01 00:00:00

  • Improving Cure Rates in Onychomycosis.

    abstract:BACKGROUND:Onychomycosis is a persistent fungal nail infection that is notoriously hard to treat. Approximately 20% to 25% of patients with onychomycosis do not respond to treatment, and 10% to 53% of patients relapse. As such, successful treatment is imperative for long-term disease management. OBJECTIVE:To identify ...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1177/1203475416653734

    authors: Gupta AK,Cernea M,Foley KA

    更新日期:2016-11-01 00:00:00

  • Diseases of abnormal sensitivity to cold in children on psychostimulant drugs.

    abstract:BACKGROUND:Oral psychostimulant (PS) drugs, the pharmacologic treatment of choice for attention-deficit/hyperactivity disorder (ADHD), have been associated with diseases of abnormal sensitivity to cold (DASC) such as Raynaud phenomenon and acrocyanosis. OBJECTIVES:In a cohort of pediatric patients with DASC, we sought...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.2310/7750.2014.14052

    authors: Coulombe J,Powell J,Hatami A,McCuaig C,Renet S,Marcoux D

    更新日期:2015-03-01 00:00:00

  • Elastosis perforans serpignosa: treatment with liquid nitrogen cryotherapy and review of the literature.

    abstract:BACKGROUND:Elastosis perforans serpiginosa (EPS) is a rare skin disease in which abnormal elastic tissue fibers, other connective tissue elements, and cellular debris are expelled from the papillary dermis via transepithelial elimination. It is characterized by an eruption of small grouped hyperkeratotic papules in a s...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.2310/7750.2009.08064

    authors: Humphrey S,Hemmati I,Randhawa R,Crawford RI,Hong CH

    更新日期:2010-01-01 00:00:00

  • Needs survey of Canadian rosacea patients.

    abstract:BACKGROUND:In 1995, a Rosacea Awareness Program (RAP) was initiated in Canada to make available educational resources for physicians and rosacea patients. Material is in French or English, and is accessible though physician offices and by toll-free telephone. Information was communicated to the public via noncommercial...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/120347549900300403

    authors: Shear NH,Levine C

    更新日期:1999-04-01 00:00:00

  • Regulation of plasma substance P and skin mast cells by odorants.

    abstract:BACKGROUND:Mast cells stimulate inflammation and itch sensation in the skin by releasing various mediators when they are activated. Stress exacerbates some skin diseases. We have reported that inhalation of certain odorants modulates immune reactions in the skin. OBJECTIVE:The possible usage of odorants in the regulat...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1007/s10227-002-0129-y

    authors: Hosoi J,Tanida M,Tsuchiya T

    更新日期:2003-07-01 00:00:00

  • Stephen Rothman's text on physiology and biochemistry of the skin.

    abstract:BACKGROUND:Forty-nine years ago the first complete and authoritative English text on the physiology and biochemistry of the skin was published by Stephen Rothman, an early basic researcher in dermatology. OBJECTIVE:The purpose of the article is to learn more about Stephen Rothman and his 1954 text, to learn more about...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 传,历史文章,杂志文章

    doi:10.1007/s10227-005-0040-4

    authors: Jackson R

    更新日期:2004-09-01 00:00:00

  • Filiform Verrucous Sarcoidosis of the Face: A Warty Report.

    abstract::Sarcoidosis is a multisystem inflammatory condition of unknown etiology. Variability in the cutaneous features of sarcoidosis is profound, and its protean manifestations affirm the condition's designation as one of dermatology's "great mimics." Cutaneous phenotypes of sarcoidosis include but are by no means limited to...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/1203475418763590

    authors: Hudson AD,Klimas NK,Stetson CL

    更新日期:2018-07-01 00:00:00

  • Public Engagement with Dermatology Contents on Facebook.

    abstract:BACKGROUND:The gtring presence of dermatology platforms on Facebook has been acknowledged; however, little is known about the extent to which different types of content influence the level of engagement with online users. OBJECTIVE:To assess the level of public engagement with different types of content posted on Face...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.2310/7750.2014.14119

    authors: Kim WB,Marinas JE,Vender RB

    更新日期:2015-05-01 00:00:00

  • Eruptive squamous cell carcinomas after vemurafenib therapy.

    abstract:BACKGROUND:Vemurafenib is an oral BRAF inhibitor recently approved for the treatment of metastatic melanoma. Patients treated with this medication have been reported to have the occurrence of squamous cell carcinoma (SCC) and/or actinic keratosis (AK). OBJECTIVE:We report the case of a patient treated with vemurafenib...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.2310/7750.2013.12092

    authors: Mays R,Curry J,Kim K,Tsai K,Arora A,Khan F,Ramirez-Fort M,Ciurea A

    更新日期:2013-11-01 00:00:00

  • Arachidonic acid-derived bioactive lipids: their role and the role for their inhibitors in dermatology.

    abstract:BACKGROUND:In addition to corticosteroids, there are increasing numbers of anti-inflammatory agents that specifically target bioactive lipids generated from arachidonic acid. Knowledge of the diverse mechanisms of action of these different bioactive lipids holds promise in the therapy of a wide spectrum of cutaneous an...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,评审

    doi:10.1007/s10227-001-0047-4

    authors: Smith KJ,Skelton H

    更新日期:2002-05-01 00:00:00

  • What's in a name? Comments on the dermatological dictionary by Ledier, Rosenblum, and Carter.

    abstract:BACKGROUND:Any scientific discipline needs a sharply defined set of words for exact and reproducible communication. Surprisingly this has never been a strong point in dermatological science, especially as regards the living gross pathology of skin disease. OBJECTIVE:This article briefly reviews the four editions of a ...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1007/s10227-001-0016-y

    authors: Jackson R

    更新日期:2001-11-01 00:00:00

  • Retrospective Review of Folliculitis Decalvans in 23 Patients with Course and Treatment Analysis of Long-standing Cases.

    abstract:BACKGROUND:To date, there is no standard treatment of folliculitis decalvans (FD), a rare type of cicatricial alopecia. OBJECTIVE AND METHODS:The records of 23 patients with FD (1998-2012) were retrospectively analyzed, with added data review on the course and treatment of long-standing cases. RESULTS:Initial managem...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:

    authors: Bunagan MJ,Banka N,Shapiro J

    更新日期:2014-10-01 00:00:00

  • Olanzapine may be an effective adjunctive therapy in the management of acne excoriée: a case report.

    abstract:BACKGROUND:The self-inflicted dermatoses such as acne excorieé and neurotic excoriations are often chronic, recurring, and resistant to standard dermatologic therapies. OBJECTIVE:We present a 28-year-old woman with longstanding acne excorieé, whose acne started at age 14 years and was followed by acne excorieé at age ...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1177/120347540100500106

    authors: Gupta MA,Gupta AK

    更新日期:2001-01-01 00:00:00

  • Betamethasone valerate foam for treatment of nonscalp psoriasis.

    abstract:BACKGROUND:Although betamethasone valerate (BMV) foam, 0.12% (Luxiq, Connectics Corporation, Palo Alto, CA) is approved by the Food and Drug Administration for the treatment of corticosteroid-responsive scalp dermatoses, no data are available for its use on nonscalp psoriasis. OBJECTIVE:We evaluated the safety and eff...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s10227-001-0006-0

    authors: Stein LF,Sherr A,Solodkina G,Gottlieb AB,Chaudhari U

    更新日期:2001-07-01 00:00:00

  • Erythema multiforme major associated with CMV infection in an immunocompetent patient.

    abstract:BACKGROUND:Cytomegalovirus (CMV) infection usually remains asymptomatic in immunocompetent adults, and few cases of complicated disease in nonimmunosuppressed patients have been reported. Erythema multiforme (EM), an acute and self-limiting skin eruption characterized by a typical targetoid lesion that may also affect ...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.2310/7750.2011.10020

    authors: Vitiello M,Echeverria B,Elgart G,Kerdel F

    更新日期:2011-03-01 00:00:00

  • Successful treatment of refractory aquagenic pruritus with naltrexone.

    abstract:BACKGROUND:Aquagenic pruritus is an intense prickling sensation that develops in affected individuals immediately after contact with water at any temperature. It is most commonly associated with polycythemia rubra vera. Common but often ineffective treatments include anticholinergics and antihistamines. Other moderatel...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章

    doi:10.1007/s10227-005-0144-x

    authors: Ingber S,Cohen PD

    更新日期:2005-10-01 00:00:00