A clinicopathologic review of a case series of dermatofibrosarcoma protuberans with fibrosarcomatous differentiation.


BACKGROUND:Dermatofibrosarcoma protuberans with fibrosarcomatous differentiation (DFSP-FS) is a rare variant of DFSP with a more aggressive clinical course, characterized by higher rates of local recurrence, metastasis, and death. METHODS:We conducted a clinicopathologic review of all DFSP-FS cases that occurred in Alberta, Canada, from 1997 to 2007. RESULTS:Of the 75 DFSP cases reviewed, 4 demonstrated fibrosarcomatous differentiation. Three patients were female and one was male, and the age range was 25 to 76 years. Three tumors invaded to skeletal muscle, whereas one invaded to subcutaneous tissue only. Although perineural invasion was noted in all four cases, none exhibited lymphovascular space invasion. One local recurrence developed, and two of four tumors metastasized. Metastasis was associated with tumor size, tumor necrosis, grenz zone involvement, ulceration, thickness, and tumor grade. One patient died within 5 years of diagnosis. CONCLUSION:DFSP-FS represents a more aggressive subtype of DFSP. Several features of DFSP-FS may impart a higher risk of metastasis.


J Cutan Med Surg


Kuzel P,Mahmood MN,Metelitsa AI,Salopek TG




Has Abstract


2015-01-01 00:00:00














  • Non-melanoma Skin Cancer in Canada Chapter 5: Management of Squamous Cell Carcinoma.

    abstract:BACKGROUND:Squamous cell carcinoma (SCC) is the second-most common form of non-melanoma skin cancer (NMSC). OBJECTIVE:To provide guidance to Canadian health care practitioners regarding management of SCCs. METHODS:Literature searches and development of graded recommendations were carried out as discussed in the accom...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章,实务指引


    authors: Sapijaszko M,Zloty D,Bourcier M,Poulin Y,Janiszewski P,Ashkenas J,Canadian Non-melanoma Skin Cancer Guidelines Committee.

    更新日期:2015-05-01 00:00:00

  • Treatment decision needs of psoriasis patients: cross-sectional survey.

    abstract:BACKGROUND:Informed shared decision making is a mutual process engaging both doctor and patient and informed by best medical evidence and patient values and preferences. OBJECTIVE:Our aim was to identify the needs of psoriasis patients in decisions on selecting treatment. METHODS:Psoriasis subjects participated in an...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Tan J,Stacey D,Fung K,Barankin B,Bissonnette R,Gulliver W,Lui H,Shear N,Jackson C,Zhang X

    更新日期:2010-09-01 00:00:00

  • Cutaneous sarcoidosis successfully treated with alefacept.

    abstract:BACKGROUND:Sarcoidosis is a systemic granulomatous disease of unknown etiology that affects multiple organ systems, including the pulmonary, lymphatic, skeletal, and integumentary systems. Improved understanding of the intrinsic immunology and molecular biology in sarcoidosis can be applied to the treatment of this dis...

    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Garcia-Zuazaga J,Korman NJ

    更新日期:2006-11-01 00:00:00

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    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Rivers JK,Rosoph L,Provost N,Bissonnette R

    更新日期:2008-05-01 00:00:00

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    pub_type: 杂志文章


    authors: Czilli T,Tan J,Knezevic S,Peters C

    更新日期:2016-11-01 00:00:00

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    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


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    更新日期:2017-07-01 00:00:00

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    更新日期:2016-11-01 00:00:00

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    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Showler A,Boggild AK

    更新日期:2012-11-01 00:00:00

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    更新日期:2017-11-01 00:00:00

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    更新日期:2016-09-01 00:00:00

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    journal_title:Journal of cutaneous medicine and surgery

    pub_type: 杂志文章


    authors: Lacroix JP,Wang B

    更新日期:2017-01-01 00:00:00

  • Improving Cure Rates in Onychomycosis.

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    authors: Coulombe J,Powell J,Hatami A,McCuaig C,Renet S,Marcoux D

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    authors: Humphrey S,Hemmati I,Randhawa R,Crawford RI,Hong CH

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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