Ingenol mebutate: a promising treatment for actinic keratoses and nonmelanoma skin cancers.

Abstract:

BACKGROUND:A new treatment for actinic keratoses, ingenol mebutate, was recently approved by the US Food and Drug Administration. OBJECTIVE:To review the mechanisms of action, efficacy and safety data, and practical recommendations for ingenol mebutate. METHODS:The PubMed and clinicaltrials.gov databases were searched in March/April 2012 using the terms PEP005, ingenol mebutate, and ingenol 3-angelate. The abstracts from the Annual Scientific Meeting of the Australian College of Dermatologists (2009-2011) and the Annual Meeting of the American Academy of Dermatology (2009-2012) were also searched. RESULTS:Due to its multiple mechanisms of action, ingenol mebutate treatment resulted in short- and long-term efficacy similar to other topical treatments for actinic keratoses in a shorter period of 2 or 3 days. This short therapy would reduce the duration of adverse events. Premarketing trials for treatment of nonmelanoma skin cancers also showed promising results for ingenol mebutate. CONCLUSION:Ingenol mebutate is a convenient, safe, and effective intervention for precancerous and cancerous skin conditions.

journal_name

J Cutan Med Surg

authors

Gupta AK,Paquet M

doi

10.2310/7750.2012.12050

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

173-9

issue

3

eissn

1203-4754

issn

1615-7109

journal_volume

17

pub_type

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