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A systematic approach to selecting task relevant neurons.

Abstract：

BACKGROUND:Since task related neurons cannot be specifically targeted during surgery, a critical decision to make is to select which neurons are task-related when performing data analysis. Including neurons unrelated to the task degrade decoding accuracy and confound neurophysiological results. Traditionally, task-related neurons are selected as those with significant changes in firing rate when a stimulus is applied. However, this assumes that neurons' encoding of stimuli are dominated by their firing rate with little regard to temporal dynamics. NEW METHOD:This paper proposes a systematic approach for neuron selection, which uses a likelihood ratio test to capture the contribution of stimulus to spiking activity while taking into account task-irrelevant intrinsic dynamics that affect firing rates. This approach is denoted as the model deterioration excluding stimulus (MDES) test. RESULTS:MDES is compared to firing rate selection in four case studies: a simulation, a decoding example, and two neurophysiology examples. COMPARISON WITH EXISTING METHODS:The MDES rankings in the simulation match closely with ideal rankings, while firing rate rankings are skewed by task-irrelevant parameters. For decoding, 95% accuracy is achieved using the top 8 MDES-ranked neurons, while the top 12 firing-rate ranked neurons are needed. In the neurophysiological examples, MDES matches published results when firing rates do encode salient stimulus information, and uncovers oscillatory modulations in task-related neurons that are not captured when neurons are selected using firing rates. CONCLUSIONS:These case studies illustrate the importance of accounting for intrinsic dynamics when selecting task-related neurons and following the MDES approach accomplishes that. MDES selects neurons that encode task-related information irrespective of these intrinsic dynamics which can bias firing rate based selection.

journal_name

J Neurosci Methods

journal_title

Journal of neuroscience methods

authors

Kahn K,Saxena S,Eskandar E,Thakor N,Schieber M,Gale JT,Averbeck B,Eden U,Sarma SV

doi

10.1016/j.jneumeth.2015.02.020

subject

Has Abstract

pub_date

2015-04-30 00:00:00

pages

156-68

eissn

0165-0270

issn

1872-678X

pii

S0165-0270(15)00072-2

journal_volume

245

pub_type

杂志文章

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A systematic approach to selecting task relevant neurons.