Abstract:
:We have developed a novel, low-cost device designed to monitor and modulate locomotor activity in murine subjects. This technology has immediate application to the study of effects of physical exercise on various neurobiological endpoints, and will also likely be useful in the study of psychomotor sensitization and drug addiction. Here we demonstrate the capacity of these devices to establish locomotor activity as an operant response reinforced by food pellet presentations, and show that schedules of reinforcement can reliably control this behavior. Importantly, these data show that varying degrees of increased locomotor activity (in other words, "exercise") can be elicited and maintained in mice by manipulating the schedule of reinforcement. Our findings argue that the present technology might reduce the imposition of stress and motivational bias inherent in more traditional procedures for establishing exercise in laboratory rodents, while allowing for true random assignment to experimental groups. As interest in physical exercise as a modulating factor in numerous clinical conditions continues to grow, technologies like the one proposed here are likely to become critical in conducting future experiments along these lines.
journal_name
J Neurosci Methodsjournal_title
Journal of neuroscience methodsauthors
Fantegrossi WE,Xiao WR,Zimmerman SMdoi
10.1016/j.jneumeth.2012.10.020subject
Has Abstractpub_date
2013-01-30 00:00:00pages
338-43issue
2eissn
0165-0270issn
1872-678Xpii
S0165-0270(12)00445-1journal_volume
212pub_type
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