Pathophysiological mechanisms of brain edema development: role of tissue factors.

abstract：BACKGROUND AND PURPOSE:We demonstrated previously that treatment with selective kappa-opioid receptor (KOR) agonist BRL 52537 hydrochloride [(+/-)-1-(3,4-dichlorophenyl) acetyl-2-(1-pyrrolidinyl) methylpiperidine] (1) has a long therapeutic window for providing ischemic neuroprotection, and (2) attenuates ischemia-evok...

journal_title：Stroke

authors： Chen CH,Toung TJ,Hurn PD,Koehler RC,Bhardwaj A

更新日期：2005-07-01 00:00:00

abstract：:To assess the importance of occult atrial disorder with possible embolization as a cause of non-hemorrhagic stroke, 68 patients with neurologic symptoms lasting 24 hours or more and 18 patients with transient ischemic attacks were examined by long-term electrocardiographic recording (LTER). Lacking matched controls we...

journal_title：Stroke

authors： Abdon NJ,Zettervall O,Carlson J,Berglund S,Sterner G,Tejler L,Turesson I

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Brain atrophy can be regarded as an end-organ effect of cumulative cardiovascular risk factors. Accelerated brain atrophy is described following ischemic stroke, but it is not known whether atrophy rates vary over the poststroke period. Examining rates of brain atrophy allows the identification o...

journal_title：Stroke

authors： Brodtmann A,Khlif MS,Egorova N,Veldsman M,Bird LJ,Werden E

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke in young adults has a dramatic effect on life; therefore, we investigated the long-term functional outcome after transient ischemic attack, ischemic stroke, or intracerebral hemorrhage in adults aged 18 to 50 years. METHODS:We studied 722 young patients with first-ever stroke admitted bet...

journal_title：Stroke

authors： Synhaeve NE,Arntz RM,Maaijwee NA,Rutten-Jacobs LC,Schoonderwaldt HC,Dorresteijn LD,de Kort PL,van Dijk EJ,de Leeuw FE

更新日期：2014-04-01 00:00:00

abstract：:Background and Purpose- To test the hypothesis that covert brain infarcts (CBIs) are more likely to be located in noneloquent brain areas compared with clinical strokes and that CBI etiological subtypes carry a differential risk of vascular events compared with people without CBI. Methods- We used brain magnetic reson...

journal_title：Stroke

authors： Gutierrez J,Gil-Guevara A,Ramaswamy S,DeRosa J,Di Tullio MR,Cheung K,Rundek T,Sacco RL,Wright CB,Elkind MSV

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:When carotid artery tandem lesions are present, the benefits of carotid endarterectomy (CEA) to reduce recurrent stroke remain uncertain. The present retrospective cohort study aimed to determine the clinical outcomes of CEA for carotid artery tandem stenosis that was diagnosed by contrast-enhanc...

journal_title：Stroke

authors： Han Y,Park H,Kwon SU,Kang DW,Lee DH,Kwon H,Kwon TW,Cho YP,Kim GE

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The natural product baicalein is a specific inhibitor of 12/15-lipoxygenase, but it also has antioxidant properties. The current study was designed to test if the neuroprotective properties of baicalein are related to its lipoxygenase inhibition. METHODS:The presence of 12/15-lipoxygenase in the...

journal_title：Stroke

authors： van Leyen K,Kim HY,Lee SR,Jin G,Arai K,Lo EH

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Iron overload has been associated with greater oxidative stress and brain injury in experimental cerebral ischemia and reperfusion. This study investigates whether high serum ferritin levels, as an index of increased cellular iron stores, are associated with poor outcome, hemorrhagic transformati...

journal_title：Stroke

authors： Millan M,Sobrino T,Castellanos M,Nombela F,Arenillas JF,Riva E,Cristobo I,García MM,Vivancos J,Serena J,Moro MA,Castillo J,Dávalos A

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:In prehension tasks with objects placed within arm's reach, patients with hemiparesis caused by stroke use excessive trunk movement to compensate for arm motor impairments. Compensatory trunk movements may improve motor function in the short term but may limit arm recovery in the long term. Previ...

journal_title：Stroke

authors： Michaelsen SM,Levin MF

更新日期：2004-08-01 00:00:00

abstract：:Background and Purpose- We aimed to define the neuroimaging determinants of poststroke cognitive performance and their relative contributions among a spectrum of magnetic resonance imaging markers, including lesion burden and strategic locations. Methods- We prospectively included patients with stroke from the GRECogV...

journal_title：Stroke

authors： Puy L,Barbay M,Roussel M,Canaple S,Lamy C,Arnoux A,Leclercq C,Mas JL,Tasseel-Ponche S,Constans JM,Godefroy O,GRECogVASC Study Group.

更新日期：2018-11-01 00:00:00

abstract：:Regional cerebral blood flow, blood volume, fractional oxygen extraction, and oxygen consumption were measured by positron emission tomography in 4 stroke patients prior to and 6 months following omental transposition surgery. Preoperatively, 3 patients showed the typical picture of established infarction with a match...

journal_title：Stroke

authors： Herold S,Frackowiak RS,Neil-Dwyer G

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of this study was to investigate the periprocedural morbidity, mortality, and long-term clinical and angiographic follow-up using stent-assisted coiling and stenting alone for treatment of cranial fusiform dissecting and atherosclerotic aneurysms. METHODS:The Institutional Review Boa...

journal_title：Stroke

authors： Wakhloo AK,Mandell J,Gounis MJ,Brooks C,Linfante I,Winer J,Weaver JP

更新日期：2008-12-01 00:00:00

abstract：:As part of a prospective study of mood disorders in stroke patients, interviews were obtained from 37 patients at 1 year and 48 patients at 2 years follow-up. In-hospital evaluations for these 65 follow-up patients found that 9 patients (14%) had symptom clusters of major depression, 12 patients (18%) had symptom clus...

journal_title：Stroke

authors： Robinson RG,Bolduc PL,Price TR

更新日期：1987-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Spreading depressions (SDs) occur in experimental focal ischemia and contribute to lesion evolution. N-Methyl-D-aspartate (NMDA) antagonists inhibit SDs and reduce infarct size. The glycine site on the NMDA receptor complex offers a therapeutic target for acute focal ischemia, potentially devoid ...

journal_title：Stroke

authors： Tatlisumak T,Takano K,Meiler MR,Fisher M

更新日期：1998-01-01 00:00:00

abstract：:Background and Purpose- Cerebral small vessel disease (cSVD) is the major vascular cause of cognitive decline and dementia. The pathogenesis of cSVD remains largely unknown, although several studies suggest a role for systemic inflammation. In certain pathophysiological situations, monocytes can reprogram toward a lon...

journal_title：Stroke

authors： Noz MP,Ter Telgte A,Wiegertjes K,Joosten LAB,Netea MG,de Leeuw FE,Riksen NP

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The combination of low-dose aspirin and dipyridamole is more effective than aspirin alone in reducing the risk of recurrent stroke and other major cardiovascular events in patients with a recent transient ischemic attack or minor stroke. It is unknown whether this also applies to patients with a ...

journal_title：Stroke

authors： Dippel DW,Maasland L,Halkes P,Kappelle LJ,Koudstaal PJ,Algra A,ESPRIT Study Group and the ESPS-2 Investigators.

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Large pulse pressure associates with atherosclerosis, but it is unclear if it contributes to the development of atherosclerosis or if atherosclerosis leads to pulse pressure widening. We examined whether exposure to large pulse pressure in childhood predicts carotid artery intima-media thickness ...

journal_title：Stroke

authors： Raitakari OT,Juonala M,Taittonen L,Jula A,Laitinen T,Kähönen M,Viikari JS

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Apraxia of speech (AOS) is a motor speech disorder, which is clinically characterized by the combination of phonemic segmental changes and articulatory distortions. AOS has been believed to arise from impairment in motor speech planning/programming and differentiated from both aphasia and dysarth...

journal_title：Stroke

authors： Itabashi R,Nishio Y,Kataoka Y,Yazawa Y,Furui E,Matsuda M,Mori E

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Iron is an essential element for the human body. It has, however, been suggested that excessive iron stores may increase the risk of vascular disease. So far, epidemiologic studies on stroke are sparse. METHODS:We studied the association between iron status and stroke risk in a population-based ...

journal_title：Stroke

authors： van der A DL,Grobbee DE,Roest M,Marx JJ,Voorbij HA,van der Schouw YT

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Although cerebral penetrating arterioles are main regulators of the brain microcirculation, little is known about the effect of endothelium-derived relaxation factor on these vessels. This study examined the effects of nitric oxide synthase inhibitors on the spontaneous tone of isolated rat cereb...

journal_title：Stroke

authors： Kimura M,Dietrich HH,Dacey RG Jr

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke symptoms in the absence of recognized stroke are common, but potential associated dysfunctions have not been described. METHODS:We assessed quality-of-life measures using the Physical and Mental Component Summary scores of the Short Form 12 (PCS-12 and MCS-12) in the REasons for Geographi...

journal_title：Stroke

authors： Howard G,Safford MM,Meschia JF,Moy CS,Howard VJ,Pulley L,Gomez CR,Crowther M

更新日期：2007-09-01 00:00:00

abstract：:Brief episodes of ischemia can protect against subsequent damaging ischemic events; however, the molecular mechanisms responsible for protection are poorly understood. Identifying genes involved in this process could provide insight into cell survival and treatment of stroke. We developed a murine model of ischemic pr...

journal_title：Stroke

authors： Stenzel-Poore MP,Stevens SL,Simon RP

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To evaluate the impact of proximal flow control on efficacy and safety of mechanical thrombectomy in an in vitro middle cerebral artery occlusion. METHODS:Three independent variables, including clot type, device (Merci Retriever, Solitaire FR, and Trevo devices), and use of a balloon guide cathe...

journal_title：Stroke

authors： Chueh JY,Kühn AL,Puri AS,Wilson SD,Wakhloo AK,Gounis MJ

更新日期：2013-05-01 00:00:00

abstract：:Background and Purpose- This ARISTOPHANES study (Anticoagulants for Reduction in Stroke: Observational Pooled Analysis on Health Outcomes and Experience of Patients) used multiple data sources to compare stroke/systemic embolism (SE) and major bleeding (MB) among a large number of nonvalvular atrial fibrillation patie...

journal_title：Stroke

authors： Lip GYH,Keshishian A,Li X,Hamilton M,Masseria C,Gupta K,Luo X,Mardekian J,Friend K,Nadkarni A,Pan X,Baser O,Deitelzweig S

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ischemic injury triggers multiple pathological responses in the brain tissue, including spreading depolarizations across the cerebral cortex (cortical spreading depolarizations [CSD]). Microglia have been recently shown to play a significant role in the propagation of CSD. However, the intracellu...

journal_title：Stroke

authors： Liu L,Kearns KN,Eli I,Sharifi KA,Soldozy S,Carlson EW,Scott KW,Sluzewski MF,Acton ST,Stauderman KA,Kalani MYS,Park M,Tvrdik P

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The Emergency Medical Services field triage to stroke centers has gained considerable complexity with the recent demonstration of clinical benefit of endovascular treatment for acute ischemic stroke. We sought to describe a new smartphone freeware application designed to assist Emergency Medical ...

journal_title：Stroke

authors： Nogueira RG,Silva GS,Lima FO,Yeh YC,Fleming C,Branco D,Yancey AH,Ratcliff JJ,Wages RK,Doss E,Bouslama M,Grossberg JA,Haussen DC,Sakano T,Frankel MR

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A previous systematic review of randomized trials suggested a positive effect of antiplatelet therapy in patients with aneurysmal subarachnoid hemorrhage (SAH). We performed a randomized controlled trial to assess whether acetylsalicylic acid (ASA) reduces the risk of delayed ischemic neurologica...

journal_title：Stroke

authors： van den Bergh WM,MASH Study Group.,Algra A,Dorhout Mees SM,van Kooten F,Dirven CM,van Gijn J,Vermeulen M,Rinkel GJ

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of this study was to further analyze the temporal patterns of onset of intracerebral hemorrhage (ICH) and to determine whether or not subgroups with specific clinical characteristics exhibit different patterns of onset. METHODS:The daily, weekly, and yearly variations in occurrence o...

journal_title：Stroke

authors： Passero S,Reale F,Ciacci G,Zei E

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Growth of an intracranial aneurysm occurs in around 10% of patients at 2-year follow-up imaging and may be associated with aneurysm rupture. We investigated whether PHASES, a score providing absolute risks of aneurysm rupture based on 6 easily retrievable risk factors, also predicts aneurysm grow...

journal_title：Stroke

authors： Backes D,Vergouwen MD,Tiel Groenestege AT,Bor AS,Velthuis BK,Greving JP,Algra A,Wermer MJ,van Walderveen MA,terBrugge KG,Agid R,Rinkel GJ

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Stroke-induced neuroinflammation and white matter damage are associated with neurological deficits. Whether D-4F, an apolipoprotein A-I mimetic peptide, treatment of stroke decreases neuroinflammation and white matter damage and improves functional outcome has not been investigated. METHODS:Adul...

journal_title：Stroke

authors： Cui X,Chopp M,Zacharek A,Cui C,Yan T,Ning R,Chen J

更新日期：2016-01-01 00:00:00