Abstract:
:Spleen cells from normal or preimmunized mice were exposed to graded doses of peak pions or 300-kVp x rays in vitro and then cultured in heavily irradiated mice to determine antibody production against sheep erythrocytes. The RBE for the primary antibody response was 1.46. Equal suppression of secondary responses was seen with both pions and x rays. When spleen cells were irradiated 1, 3, or 5 days after antigen injection, developing immune responses became less sensitive to pions than to x rays. Because T-cell activity (needed for the antibody response) is also implicated in tumor immunity, antitumor immune responses might not be more sensitive to pions than the response used; also, pions might not impair ongoing autochthonous immune responses more than conventional radiation modalities do.
journal_name
Radiologyjournal_title
Radiologyauthors
Carlson DEdoi
10.1148/126.3.803subject
Has Abstractpub_date
1978-03-01 00:00:00pages
803-6issue
3eissn
0033-8419issn
1527-1315journal_volume
126pub_type
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