Abstract:
PURPOSE:To assess the efficacy of perioperative implantation of iridium-192 for stage I and II breast cancer. MATERIALS AND METHODS:The authors retrospectively reviewed findings from 655 patients with stage I and II cancer treated with conservative surgery and Ir-192 implantation between 1982 and 1992. Hollow plastic tubes were placed in the tumor bed as a single- or double-plane implant at lumpectomy. Ribbons with Ir-192 seeds were inserted into the tubes 4-6 hours later. The Ir-192 was left in place for approximately 50 hours. External-beam irradiation was given to the whole breast 10-14 days later. RESULTS:Follow-up ranged from 2 to 146 months. The local control at 10 years for stage I and II disease was 93% and 87%, respectively. The 10-year actuarial survival rate was 92% +/- 1 for stage I disease and 72% +/- 4 for stage II disease. The rate of survival with no evidence of disease for stage I and II disease combined was 82% +/- 1 at 5 years and 75% +/- 3 at 10 years. CONCLUSION:Perioperative implantation produced excellent local control equal to that with electron-beam therapy.
journal_name
Radiologyjournal_title
Radiologyauthors
Mansfield CM,Komarnicky LT,Schwartz GF,Rosenberg AL,Krishnan L,Jewell WR,Rosato FE,Moses ML,Barbot D,Cohn HEdoi
10.1148/radiology.192.1.8208960subject
Has Abstract,Author List Incompletepub_date
1994-07-01 00:00:00pages
33-6issue
1eissn
0033-8419issn
1527-1315journal_volume
192pub_type
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