Abstract:
PURPOSE:To characterize early changes in cardiac anatomy and function for lamin A/C gene (LMNA) mutation carriers by using magnetic resonance (MR) imaging and to develop tools to analyze and visualize the findings. MATERIALS AND METHODS:The ethical review board of the institution approved the study, and informed written consent was obtained. The patient group consisted of 12 subjects, seven women (mean age, 36 years; age range, 18-54 years) and five men (mean age, 28 years; age range, 18-39 years) of Finnish origin, who were each heterozygotes with one LMNA mutation that may cause familial dilated cardiomyopathy (DCM). All the subjects were judged to be healthy with transthoracic echocardiography. The control group consisted of 14 healthy subjects, 11 women (mean age, 41 years; range, 23-54 years) and three men (mean age, 45 years; range, 34-57 years), of Finnish origin. Cine steady state free precession MR imaging was performed with a 1.5-T system. The volumes, wall thickness, and wall motion of both left ventricle (LV) and right ventricle were assessed. A method combining multiple MR image parameters was used to generate a global cardiac function index, the disease state parameter (DSP). A visual fingerprint was generated to assess the severity of familial DCM. RESULTS:The mean DSP of the patient group (0.69 +/- 0.15 [standard deviation]) was significantly higher than that of the control group (0.32 +/- 0.13) (P = .00002). One subject had an enlarged LV. CONCLUSION:Subclinical familial DCM was identified by determination of the DSP with MR imaging, and this method might be used to recognize familial DCM at an early stage.
journal_name
Radiologyjournal_title
Radiologyauthors
Koikkalainen JR,Antila M,Lötjönen JM,Heliö T,Lauerma K,Kivistö SM,Sipola P,Kaartinen MA,Kärkkäinen ST,Reissell E,Kuusisto J,Laakso M,Oresic M,Nieminen MS,Peuhkurinen KJdoi
10.1148/radiol.2491071584subject
Has Abstractpub_date
2008-10-01 00:00:00pages
88-96issue
1eissn
0033-8419issn
1527-1315pii
249/1/88journal_volume
249pub_type
杂志文章相关文献
RADIOLOGY文献大全abstract::Background Glomerulonephritis refers to renal diseases characterized by glomerular and tubulointerstitial fibrosis. Multifrequency US time-harmonic elastography enables the noninvasive quantification of tissue elasticity. Purpose To assess the diagnostic performance of US time-harmonic elastography for the early detec...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2019182574
更新日期:2019-09-01 00:00:00
abstract::The computed tomographic findings in a patient with lead encephalopathy are described. The predominantly unilateral abnormalities and the clinical history were suggestive of a cerebral tumor. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/123.1.91
更新日期:1977-04-01 00:00:00
abstract:PURPOSE:To retrospectively determine the frequency of diaphragmatic injury when percutaneous hepatic radiofrequency (RF) ablation is performed adjacent to the diaphragm. MATERIALS AND METHODS:Institutional Review Board approval was obtained for our HIPAA-compliant study. Informed consent for the ablation procedure and...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2433060157
更新日期:2007-06-01 00:00:00
abstract:PURPOSE:To compare the effects of various stents on magnetic resonance (MR) imaging flow volume measurements and to determine the value of a blood-pool MR imaging contrast medium in assessment of vascular stents. MATERIALS AND METHODS:In 11 pigs, six nitinol stents (Memotherm), four platinum stents (NuMed), and one el...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2232010975
更新日期:2002-05-01 00:00:00
abstract:PURPOSE:To compare the diagnostic accuracy of two-dimensional (2D) full-field digital mammography with that of two-view (mediolateral and craniocaudal) and single-view (mediolateral oblique) tomosynthesis in an observer study involving two institutions. MATERIALS AND METHODS:Ethical committee approval was obtained. Al...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.11103514
更新日期:2012-03-01 00:00:00
abstract::Successful balloon catheter dilatation through the defunctionalized limb of a colostomy was performed in three infants with postischemic colonic stricture. This experience suggests that balloon catheter dilatation can be an alternative to surgical resection in treating delayed ischemic colonic stricture. ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.149.2.6622690
更新日期:1983-11-01 00:00:00
abstract:PURPOSE:To assess the accuracy of glomerular filtration rate (GFR) measurements obtained with low-contrast agent dose dynamic contrast material-enhanced magnetic resonance (MR) renography in patients with liver cirrhosis who underwent routine liver MR imaging, with urinary clearance of technetium 99m ((99m)Tc) pentetic...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.11101338
更新日期:2011-05-01 00:00:00
abstract:PURPOSE:To develop criteria to identify thresholds for minimally acceptable physician performance in interpreting screening mammography studies and to profile the impact that implementing these criteria may have on the practice of radiology in the United States. MATERIALS AND METHODS:In an institutional review board-a...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.10091636
更新日期:2010-05-01 00:00:00
abstract:PURPOSE:The authors describe radiologic findings of cystic lung disease associated with pulmonary tuberculosis. MATERIALS AND METHODS:Three immunocompetent women with pulmonary tuberculosis were seen with acute respiratory failure and diffuse bilateral pulmonary opacity depicted at admission chest radiography. The wom...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.204.1.9205240
更新日期:1997-07-01 00:00:00
abstract::A technique to perform a liver biopsy through the femoral vein with the Mansfield biopsy forceps is described. Nine liver biopsy procedures were performed in seven patients who were considered at high risk of bleeding, precluding a conventional transperitoneal biopsy. The technique is an easy, safe, and well-tolerated...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.169.3.3187010
更新日期:1988-12-01 00:00:00
abstract:PURPOSE:To determine whether the Wallstent endoluminal prosthesis can be used to maintain patency of venous stenoses and occlusions related to hemodialysis access. MATERIALS AND METHODS:Wallstents were placed in 52 patients with 56 lesions. Thirty-two lesions were in central veins and 24 were in peripheral veins. Sten...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.195.2.7724770
更新日期:1995-05-01 00:00:00
abstract:PURPOSE:To review the mammographic features of screening interval breast cancers and to compare the tumor size, histologic grade, and lymph node involvement with those in screening-detected and unscreened symptomatic cancers. MATERIALS AND METHODS:Screening mammography was performed in 72,773 women aged 50-64 years. N...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.199.3.8638010
更新日期:1996-06-01 00:00:00
abstract:PURPOSE:To determine whether excess prostate-specific antigen (PSA) improves the accuracy of predicting positive biopsy results. MATERIALS AND METHODS:Results of prostate biopsy in 130 consecutive patients were correlated with transrectal ultrasound (TRUS) findings, digital rectal examination results, serum PSA level,...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.199.1.8633140
更新日期:1996-04-01 00:00:00
abstract:PURPOSE:To compare quantified measurements with color Doppler ultrasonography (US) with those obtained with conventional duplex US in the differential diagnosis of suspect lesions in the breast. MATERIALS AND METHODS:A computer-assisted protocol was used to calculate the color pixel density (CPD) and the mean color va...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.192.3.8058950
更新日期:1994-09-01 00:00:00
abstract:PURPOSE:To determine the risk of emergent dialysis and short-term mortality following intravenous iodinated contrast material exposure. MATERIALS AND METHODS:This single-center retrospective study was HIPAA compliant and institutional review board approved. All contrast material-enhanced (contrast group) and unenhance...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.14132418
更新日期:2014-12-01 00:00:00
abstract::Diatrizoate (76%) contrast agent heated to 100 degrees C was injected into the veins of dogs and one human volunteer for the nonsurgical occlusion of the vessels. Follow-up venograms and histologic examinations, at intervals varying from one day to four weeks later, revealed thrombosis of the injected veins in all ani...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.145.2.7134430
更新日期:1982-11-01 00:00:00
abstract::Adjuvant chemotherapy prolongs the survival of patients with high-grade osteosarcoma. Preoperative chemotherapy allows identification of effective agents for adjuvant chemotherapy based on response of the primary tumor. Preoperative determination of tumor response has therapeutic implications, and angiography offers a...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.170.3.2916040
更新日期:1989-03-01 00:00:00
abstract:PURPOSE:To report the authors' initial experience in treating patients with wide-neck aneurysms with assistance from a recently developed neck-bridge device (TriSpan; Target Therapeutics/Boston Scientific, Fremont, Calif). MATERIALS AND METHODS:Twenty-five patients were examined. Aneurysms were most frequently at the ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2212010474
更新日期:2001-11-01 00:00:00
abstract:PURPOSE:To retrospectively compare the pain control requirements of patients undergoing computed tomography (CT)-guided percutaneous radiofrequency (RF) ablation with those of patients undergoing CT-guided percutaneous cryoablation of small (< or = 4-cm) renal tumors. MATERIALS AND METHODS:The study was HIPAA complian...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2371040829
更新日期:2005-10-01 00:00:00
abstract:PURPOSE:To prospectively evaluate the efficacy of additional radiofrequency (RF) ablation by comparing the results of one and two sessions. MATERIALS AND METHODS:All patients gave written informed consent to participate in this institutional review board-approved prospective study. From September 2007 to February 2008...
journal_title:Radiology
pub_type: 杂志文章,随机对照试验
doi:10.1148/radiol.12111300
更新日期:2012-06-01 00:00:00
abstract:PURPOSE:To compare diffusion tensor magnetic resonance imaging with conventional T2-weighted imaging for evaluation of white matter changes in patients with Krabbe disease. MATERIALS AND METHODS:In eight patients with Krabbe disease and eight age-matched control subjects, anisotropy maps were generated with diffusion ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.218.3.r01mr14809
更新日期:2001-03-01 00:00:00
abstract:PURPOSE:To test three-dimensional (3D), navigator-echo magnetic resonance (MR) coronary angiography in detecting stenoses of the coronary arteries. MATERIALS AND METHODS:Forty-two patients (age range, 50-79 years) underwent MR coronary angiography (1.5 T). A navigator-echo sequence was used. Two or three 15% overlappe...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.214.3.r00mr01808
更新日期:2000-03-01 00:00:00
abstract::Purpose To report the results of dual-time-point gallium 68 (68Ga) prostate-specific membrane antigen (PSMA)-11 positron emission tomography (PET)/magnetic resonance (MR) imaging prior to prostatectomy in patients with intermediate- or high-risk cancer. Materials and Methods Thirty-three men who underwent conventional...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2018172232
更新日期:2018-08-01 00:00:00
abstract::Localized phosphorus-31 magnetic resonance (MR) spectroscopy in humans has previously been accomplished with surface coils by means of depth-resolved surface coil spectroscopy or rotating frame experiments, in which the extent of tissue sampled critically depends on surface coil placement. The authors' goal was to mod...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.169.2.3051120
更新日期:1988-11-01 00:00:00
abstract:PURPOSE:To compare open-magnet magnetic resonance (MR) imaging performed with the patient sitting with dynamic closed-magnet MR imaging of the pelvic floor performed with the patient supine. MATERIALS AND METHODS:Thirty-eight patients underwent dynamic 1.5-T closed-magnet pelvic floor MR imaging while in the supine po...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2232010665
更新日期:2002-05-01 00:00:00
abstract:PURPOSE:To investigate the histopathologic anatomy of calcium pyrophosphate dihydrate (CPPD) crystal deposition in and around the atlantoaxial joint and the association between CPPD crystal deposition and subchondral cysts, erosions, and fracture involving the odontoid process of the axis. MATERIALS AND METHODS:One ad...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.216.1.r00jl36213
更新日期:2000-07-01 00:00:00
abstract::Purpose To determine the prevalence of the spot sign and the accuracy of using the spot sign to predict intracerebral hemorrhage (ICH) expansion with standardized multiphase computed tomographic (CT) angiography. Materials and Methods This prospective observational cohort study included 123 consecutive patients with a...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiol.2017162839
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:To investigate the challenges and benefits of magnetic resonance (MR) imaging during brain tumor resection. MATERIALS AND METHODS:A short-bore 1.5-T MR system equipped with echo-planar-capable gradients was used in resection of brain tumors in 30 patients. MR sequences and need for contrast material enhancemen...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.215.1.r00ap31221
更新日期:2000-04-01 00:00:00
abstract:PURPOSE:To evaluate the use of magnetic resonance (MR) imaging and computed tomography (CT) for predicting the histologic grade of parosteal osteosarcomas. MATERIALS AND METHODS:Sixty parosteal osteosarcomas were analyzed for tumor size and location, presence of a cleavage plane, intramedullary extension, soft-tissue ...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.201.3.8939240
更新日期:1996-12-01 00:00:00
abstract::A new, computerized segmentation technique, in which magnetic resonance (MR) imaging produces accurate volumetric measurements of brain and cerebrospinal fluid (CSF) without the limitations of computed tomography, was used in a retrospective analysis of digitized T2-weighted MR images of 16 healthy elderly control sub...
journal_title:Radiology
pub_type: 杂志文章
doi:10.1148/radiology.178.1.1984290
更新日期:1991-01-01 00:00:00