Abstract:
:Localized phosphorus-31 magnetic resonance (MR) spectroscopy in humans has previously been accomplished with surface coils by means of depth-resolved surface coil spectroscopy or rotating frame experiments, in which the extent of tissue sampled critically depends on surface coil placement. The authors' goal was to modify the surface coil image-selected in vivo spectroscopy (ISIS) experiment to accomplish three-dimensional volume selection through application of selective pulses in the presence of B0 gradients. Advantages of ISIS include the ability to use proton images to define the volume of interest (VOI) and reduced dependence on exact positioning of the surface coil. However, rapid replication of the surface coil ISIS experiment can cause spectral contamination from signals originating outside the VOI. A modified version of the ISIS experiment was developed to alleviate contamination under conditions of rapid replication. Applications of localized P-31 MR spectroscopy for observation of high-energy phosphorus metabolites are presented in human liver, heart, and transplanted and normal kidney.
journal_name
Radiologyjournal_title
Radiologyauthors
Matson GB,Twieg DB,Karczmar GS,Lawry TJ,Gober JR,Valenza M,Boska MD,Weiner MWdoi
10.1148/radiology.169.2.3051120subject
Has Abstractpub_date
1988-11-01 00:00:00pages
541-7issue
2eissn
0033-8419issn
1527-1315journal_volume
169pub_type
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