Application of image-guided surface coil P-31 MR spectroscopy to human liver, heart, and kidney.

Abstract:

:Localized phosphorus-31 magnetic resonance (MR) spectroscopy in humans has previously been accomplished with surface coils by means of depth-resolved surface coil spectroscopy or rotating frame experiments, in which the extent of tissue sampled critically depends on surface coil placement. The authors' goal was to modify the surface coil image-selected in vivo spectroscopy (ISIS) experiment to accomplish three-dimensional volume selection through application of selective pulses in the presence of B0 gradients. Advantages of ISIS include the ability to use proton images to define the volume of interest (VOI) and reduced dependence on exact positioning of the surface coil. However, rapid replication of the surface coil ISIS experiment can cause spectral contamination from signals originating outside the VOI. A modified version of the ISIS experiment was developed to alleviate contamination under conditions of rapid replication. Applications of localized P-31 MR spectroscopy for observation of high-energy phosphorus metabolites are presented in human liver, heart, and transplanted and normal kidney.

journal_name

Radiology

journal_title

Radiology

authors

Matson GB,Twieg DB,Karczmar GS,Lawry TJ,Gober JR,Valenza M,Boska MD,Weiner MW

doi

10.1148/radiology.169.2.3051120

subject

Has Abstract

pub_date

1988-11-01 00:00:00

pages

541-7

issue

2

eissn

0033-8419

issn

1527-1315

journal_volume

169

pub_type

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