Abstract:
:A new, computerized segmentation technique, in which magnetic resonance (MR) imaging produces accurate volumetric measurements of brain and cerebrospinal fluid (CSF) without the limitations of computed tomography, was used in a retrospective analysis of digitized T2-weighted MR images of 16 healthy elderly control subjects and 16 patients with Alzheimer dementia. Ventricular and extraventricular CSF was quantified, and the effects of aging were studied; in both groups, the atrophy measurement was used to correct metabolic values obtained with positron emission tomography. Patients with Alzheimer dementia had higher total CSF; extraventricular, total ventricular, and third ventricular CSF volumes (49%, 37%, 99%, and 74%, respectively); and 7% lower brain volumes than the control group. The patients also showed a more marked decline in brain volumes and a greater increase in CSF volumes with advancing age than the control group. They had a 25.0% increase in corrected whole-brain metabolic rates; the control group had only a 15.8% increase. The use of this technique may provide a basis for further studies of aging and dementia, including regional volume analysis.
journal_name
Radiologyjournal_title
Radiologyauthors
Tanna NK,Kohn MI,Horwich DN,Jolles PR,Zimmerman RA,Alves WM,Alavi Adoi
10.1148/radiology.178.1.1984290subject
Has Abstractpub_date
1991-01-01 00:00:00pages
123-30issue
1eissn
0033-8419issn
1527-1315journal_volume
178pub_type
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