Superparamagnetic iron oxide-enhanced MR imaging: pulse sequence optimization for detection of liver cancer.

Abstract:

:The effects of magnetic resonance (MR) pulse sequences and timing parameters on tumor-liver contrast were studied in an animal model of metastatic liver cancer. Six spin-echo (SE), three inversion-recovery (IR), and four gradient-echo (GRE) sequences were evaluated at 0.6 T before and after injection of super-paramagnetic iron oxide. GRE techniques, irrespective of echo time and flip angle, showed the greatest change in signal intensity (enhancement) of the liver after administration of iron oxide. Single-acquisition GRE sequences (16 seconds) matched the contrast-to-noise ratio (C/N) performance of the most effective 6.4-minute SE sequences. Multiexcitation GRE sequences showed tumor-liver C/Ns per unit time that were significantly (P less than .05) higher than those achieved with SE and IR sequences. GRE sequences, which recruit intravoxel dephasing as an additional source of transverse relaxation enhancement (T2*), show a higher C/N per unit time and in this respect seem superior to SE and IR sequences for MR imaging with superparamagnetic iron oxide.

journal_name

Radiology

journal_title

Radiology

authors

Fretz CJ,Elizondo G,Weissleder R,Hahn PF,Stark DD,Ferrucci JT Jr

doi

10.1148/radiology.172.2.2748820

subject

Has Abstract

pub_date

1989-08-01 00:00:00

pages

393-7

issue

2

eissn

0033-8419

issn

1527-1315

journal_volume

172

pub_type

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